Abstract
There is increasing evidence that the fate of tumor development is determined by a conglomerate of circumstances acting at the time of initiation of the carcinogenic event (1). Tumors developed as a response to either a chemical, physical or biological insult do not arise at random, but require specific conditions of the host, of the target organ and of a specific target structure within that organ for the neoplastic phenomenon to take place (1,2).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Russo, J. and Russo, I.H. Is Differentiation the answer in Breast Cancer Prevention. I.R.C.S. Journal of Medical Science 10: 931 – 941, 1982.
Russo, J., Tay, L.K., and Russo, I.H. Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res. Treat. 2: 5 – 73, 1982.
Russo, J., Calaf, G., Martinez, F., Schroder, R., Tait, L., and Russo, I.H. Age-related variations in growth kinetics of primary human breast cell cultures. In Vitro16: 52, 1980.
Russo, I.H., Ireland, M., Isenberg, W., and Russo, J. Ultrastructural description of three different epithelial cell types in rat mammary gland. Proc. Electron Microscopy Soc. Am. 34: 146 – 147, 1976.
Russo, J., Isenberg, W., Ireland, M. and Russo, I.H. Ultrastructural changes in the mammary epithelial cell population during neoplastic development induced by a chemical carcinogen. Proc. Electron Microscopy Soc. Am. 34: 250 – 251, 1976.
Russo, I.H., King, M.M., Grozea, P.N. and Russo, J. Effects of dietary fat and BHT on rat mammary gland differentiation and susceptibility to carcinogenesis. Proc. Am. Assoc. Cancer Res. 22: 446a, 1981.
Russo, I.H., and Russo, J. Developmental stage of the rat mammary gland determinant of its susceptibility to 7,12-dimethyl-benz(a)anthracene. J. Natl. Cancer Inst. 61: 1439 – 1449, 1978.
Russo, J., and Russo, I.H. DNA labeling index and structure of the rat mammary gland as determinants of its susceptibility to carcinogenesis. J. Natl. Cancer Inst. 61: 1451 – 1459, 1978.
Russo, J., and Russo, I.H. Influence of differentiation and cell kinetics on the susceptibility of the rat mammary gland to carcinogenesis. Cancer Res. 40: 2677 – 2687, 1980.
Russo, J., Saby, J., Isenberg, W. and Russo, I.H. Pathogenesis of mammary carcinomas induced in rats by 7,12-dimethylbenz(a)-anthracene. J. Natl Cancer Inst. 49: 435 – 445, 1977.
Russo, J., Tait, L., and Russo, I.H. Susceptibility of the mammary gland to carcinogenesis. III. The Cell of origin of mammary carcinoma. Am. J. Pathol., 113: 50 – 66, 1983.
McGregor, D.H., Land, E.E., Choi, K., Tokuoka, S., and Liv, P.I. Breast cancer incidence among atomic bomb survivors. Hiroshima and Nagasaki, 2950–69. J. Natl. Cancer Inst. 59: 799 – 811, 1977.
Myrden, J.A., Hiltze, J.E. Breast cancer following multiple fluoroscopies during artificial pneumothorax treatment of pulmonary tuberculosis. Cancer Med. Assoc. J. 100: 1032 – 1034, 1969.
Huberman, E, Sachs, L. Cell susceptibility to transformation and cytotoxicity by the carcinogenic hydrocarbon benzo(a)pyrene. Proc. Natl. Acad. Sci. USA 56: 1123 – 1129, 1966.
Huberman, E., Sachs, L. DNA binding and its relationship to carcinogenesis by different polycyclic hydrocarbons. Int. J. Cancer 19: 122 – 127, 1977.
Tay, L.K. and Russo, J. Formation and removal of 7,12-dimethyl-benz(a)anthracene-nucleic acid adducts in rat mammary epithelial cells with different susceptibility to carcinogenesis. Carcinogenesis 2: 1327 – 1333, 1981.
Tay, L.K., and Russo, J. 7,12-dimethylbenz(a)anthracene-induced DNA binding and repair synthesis in susceptible and nonsusceptible mammary epithelial cells in culture. J. Natl. Cancer Inst. 67: 155 – 161, 1981.
Tay, L.K., Russo, I.H., Miller, J., and Russo, J. Influence on gland differentiation of binding of 7,12-dimethylbenz(a)anthracene (DMBA) to DNA of human breast epithelial cells in primary culture. In Vitro17: 201a, 1981.
Russo, J., and Russo, I.H. Early phenotypical changes in human breast epithelial cells (HBEC) treated with 7,12-dimethylbenz-(a)anthracene. Proc. Am. Assoc. Cancer Res. 25: 529a, 1984.
Geschickter, C.F., Lewis, D. Pregnancy and lactation changes in fibroadenoma of the breast. Br. Med. J. 1: 499 – 504, 1938.
Tanner, J.M. Growth at adolescence. Blackwell Scientific Publishing, Ltd, Oxford, 1962.
Dabelow, A., Die, Milchdruse. In: Handbuch der Mikrokopishen Anatomie des Menschen. Vol 3, part 3. Haut und Sinnes Organs (W. Bargmann, Ed.), Springer-Verlag, Berlin, 1957 pp. 277 – 485.
Calaf, G., Martinez, F., Russo, I.H., Roi, L. and Russo, J. The influence of age on DNA-labeling index of Human Breast Epithelium. International Research Communication System, Med. Sc. 10: 657 – 658, 1982.
Calaf, G., Martinez, F., Russo, I.H. and Russo, J. Age related variations in Growth Kinetics of primary human breast cell culture. International Research Communications System. Med. Sc. 10: 551 – 552, 1982.
Brookes, P., Lawley, P.D. Evidence for the binding of polynuclear aromatic hydrocarbons to the nucleic acids of mouse skin: Relation between carcinogenic power of hydrocarbons and their binding to DNA. Nature 202: 781 – 784, 1964.
Bulbrook, R.D., Hayward, J.L., Spicer, C.C. and Thomas, B.S. Urinary steroid excretion of normal women and women with advanced breast cancer. Lancet ii: 1235 – 1240, 1962.
Bulbrook, R.D., Hayward, J.L. and Thomas, B.S. The relation between urinary 17-hydroxycorticosteroids and 11-deoxy-17-oxosteroids and the fate of patients with mastectomy. Lancet i: 945 – 947, 1964.
Bulbrook, R.D., Hayward, J.L. and Spicer, C. Relation between urinary androgen and corticoid excretion and subsequent breast cancer. Lancet ii: 395 – 398, 1971.
Kumaoka, S., Sakauchi, N., Abe, O., Kusama, M., and Takatani, I. Urinary 17-keto-steroid excretion of women with advanced breast cancer. J. Clin. Endocrinol. Metab. 28: 667 – 672, 1968.
Sherman, B.M., and Korenman, S.G. Inadequate corpus luteum function: a pathophysiological interpretation of human breast cancer epidemiology. Cancer 33: 1306 – 1312, 1974.
Stewart, H.L., Dunham, L.J., Casper, J., Dorn, H.F., Thomas, L.B., Edgecomb, J.H. and Symeonidis, A. Epidemiology of uterine cervix and corpus, breast and ovary in Israel and New York City. J. Natl. Cancer Inst. 37L1–95, 1966.
Sunkara, P.S., Rao, P.N., and Nishioka, K. Role of putrescine in DNA synthesis in DNA synthesis and mitosis of mammalian cells. Proc. Am Assoc. Cancer Res. 18: 84a, 1977.
Surgeon General’s Report. Smoking and Health, Government Printing Office, Public Health Service Publication No. 79–50066, Washington, DC, 1979.
NAS. Particulate Polycyclic Organic Matter. National Academy of Sciences, Washington, DC, 1972.
Commoner, B., Vithayathil, A.J., Dolara, P., Sabhadra, N., Madyastha, P., and Cuca, G.C. Formation of mutagens in beef and beef extract during cooking. Science 201: 913 – 916, 1978.
Grasso, P., and O’Hare, C. Carcinogens in food. In: Chemical Carcinogens, (C.E. Searles, Ed.), American Chemical Society, Washington, DC, 1976, pp. 701 – 728.
Petrakis, N.L. Genetic cerum type, breast secretory activity, and breast cancer epidemiology. In: Genetics of Human Cancer, (J.S. Mulvihill, R.W. Miller, and J.F. Fraumeni, Jr., Eds.), Raven Press, New York, 1977, pp. 297 – 300.
Petrakis, N.L., Mason, L., Lee, R., Sugimoto, B., Pawson, S., and Catchpool, F. Association of race, age, menopausal status, and cerum type with breast fluid secretion in nonlactating women, as determined by the nipple aspiration. J. N.tl. Cancer Inst. 54: 829 – 833, 1975.
Higginson, J. The role of geographical pathology on environmental carcinogenesis. In: Twenty Fourth Annual Symposium on Fundamental Cancer Research: Environment and Cancer, Williams and Wilkins, Baltimore, 1972, pp. 69 – 79.
Allaben, W.T., Weeks, C.E., Tresp, N.C., Lovie, S.C., Lazear, E.J., and King, C.M. Mammary tumor induction in the rat by N-acyl-N-2-fluorenyl hydroxylamines: structure activity relationship. Fed. Proc. 37: 1543, 1978.
Ito, N. In: In VitroCarcinogenesis of 4 Nitroquinoline 1-oxide and Related Compounds. Carcinogenesis Vol. 6: The Nitroquinolines ( T. Sugimura, Ed.), Raven Press, N.Y. 1981.
Shirai, T., Fysh, J.M., Lee, M.S., Vaught, J.B., and King, C.M. Relationship of metabolic activation of N-hydroxy-N-acyl arylamines to biological response in the liver and mammary gland of the female CD rat. Cancer Res. 41: 4346 – 4353, 1981.
Huggins, C., Grand, L.C., and Brillantes, F.P. Critical significance of breast structure in the induction of mammary cancer in the rat. Proc. Natl. Acad. Sci. (U.S.) 45: 1294 – 1300, 1959.
Gullino, P.M., Pettigrew, H.M., and Grantham, F.H. N-Nitrosomethyl-urea as mammary gland carcinogen in rats. J. Natl. Cancer Inst. 45: 401 – 404, 1975.
Yamamoto, T., Rabinowitz, Z., Sachs, L. Identification of the chromosomes that control malignancy. Nature (New Biol) 243: 247 – 250, 1973.
Stampfer, M., Hallowes, R.C., and Hackett, A.J. Growth of normal human mammary cells in culture. In Vitro16: 415 – 425, 1980.
Hammon, S., Ham, R.G., Stampfer, M.R. Serum-free growth of human mammary epithelial cells: Rapid clonal growth in defined medium and extended serial passage with pituitary extract. 81: 5435 – 5439, 1984.
Russo, J., Furmanski, P., Bradley, R., Wells, P. and Rich, M.A. Differentiation of Normal human mammary epithelial cells in culture: An ultrastructural Study. Am. J. Anat. 145: 57 – 67, 1976.
Ceriani, R.L., Peterson, J.A. Characterization of antigens of the mouse mammary epithelial cell (MME antigens) carried on the mouse milk fat globule. Cell Diff 7: 355 – 360, 1978.
Ceriani, R.L., Peterson, J.A., Abraham, S. Immunologic methods for the identification of cell types. II. Expression of normal mouse mammary epithelial cell antigens in mammary neoplasia. J. Natl. Cancer Inst. 61: 747 – 751, 1978.
Thompson, K., Ceriani, R.L., Wong, D., Abraham, S. Immunologic methods for the identification of cell types. I. Specific antibodies that distinguish between mammary gland epithelial cells and fibroblasts. J. Natl. Cancer Inst. 57: 167 – 172, 1976.
Russo, J. Immunocytochemical Markers in Breast Cancer In: Immunocytochemistry in Tumor Diagnosis, (J. Russo, ed.), M. Nijhoff Publishing, Boston, pp 207–232, 1985.
Russo, J., and Wells, P., J. Ultrastructural localizations of adenosine triphosphatase activity in resting mammary gland. J. Histochem. Cytochem. 245: 160 – 169, 1977.
Berky, J.J., Zolotor, L. Development and characterization of cell lines of normal mouse bladder epithelial cells and 2 acetyl-aminofluorene-induced urothelial carcinoma cells grown in monolayer tissue culture. In Vitro13: 63 – 75, 1977.
Marchok, A.C., Rhetan,J.C., Nettesheim, P. In Vitrodevelopment of oncogenicity in cell lines established from tracheal epithelium preexposed in vivoto 7,12-dimethylbenz(a)anthracene. Cancer Res. 38: 2030 – 2037, 1978.
Montesano, R., Saint Vincent, L., and Tomatis, L. Malignant Transformation in vitroof rat liver cells by dimethylnitrosamine and N-Methyl-N-nitro-N-nitrosoquinoline. Br. J. Cancer 29: 214 – 220, 1973.
Smith, H.S., Lan, S., Ceriani, R., Hackett, J., and Stampfer, M. Clonal proliferation of Cultured nonmalignant and Malignant-human breast epithelia. J. Cancer Res. 41: 4637 – 4643, 1981.
Asch, B.B., Medina, D., Kretzer, F., Connally, J.L., Brenkley, B.R. Comparative responses of normal and malignant Mouse Mammary Cells to Modulation of Surface Properties. Cancer Res. 40: 2383 – 2389, 1980.
Moorhead, P.S., Nowell, P.C., Mellman, W.J., Battips, D.M., and Hungerford, D.A. Chromosome preparations of leukocytes cultured from Human peripheral blood. Exp. Cell Res. 20: 613 – 616, 1960.
Sandberg, A.A. The chromosomes in human Cancer and leukemia. New York: Elsevier/North Holland, 1980.
Cooper, G.M., Okenguist, S., and Silverman, L. Transforming activity of DNA of chemically transformed and normal cells. Nature 284: 218 – 421, 1980.
Cooper, G.M., Nieman, P.E. Transforming genes of neoplasms induced by avian lymphoid leukosis viruses. Nature, 287: 656 – 659, 1980.
Chiaho, S., Ben-Zion, S., Goldfarb, M.P., Dannenber, A., and Weinberg, R.A. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc. National Acad Sci. USA 76: 5714 – 5718, 1979.
Cooper, G.M. Cellular Transforming Genes. Science 217: 801 – 806, 1982.
Weinberg, R.A. The action of oncogenes in the cytoplasm and nucleus. Science 230: 770 – 776, 1985.
Land, Hartmut, Parada, L.F., and Weinberg, R.A. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304: 596 – 602, 1983.
Russo, J., Wilgus, G., and Russo, I.H. Susceptibility of the mammary gland to carcinogenesis. 1. Differentiation of the mammary gland as determinant of tumor incidence an type of lesion. Am. J. Pathol. 96: 721 – 736, 1979.
Russo, J., Wilgus, G., Tait, L., and Russo, I.H. Influence of age and parity on the susceptibility of rat mammary gland epithelial cells in primary cultures to 7,12-dimethylbenz(a)anthracene. In Vitro17: 877 – 884, 1981.
Stanbridge, E.J., Der, C.J., Doersen, C.J. Nishimi, R.Y., Piihl, D.M., Weissman, B. E. and Wilkinson, J.E. Human cell hybrids: Analysis of transformation and tumorigenicity. Science 214: 252 – 259, 1982.
Armitage, P., and Doll, R. The age distribution of cancer and multistage theory of carcinogenesis. Br. J. Cancer 8: 1 – 12, 1954.
Barret, J.C., and Ts’o, P.O.P. Relationship between somatic mutation and neoplastic transformation. Proc. Natl. Acad, of Sci. USA 75: 3297 – 3301, 1978.
DiPaolo, J.A. Relative Difficulties in transforming Human and Animal Cells in Vitro. J. Natl Cancer Inst. 70: 3 – 8, 1983.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Russo, J., Russo, I.H. (1987). Role of Differentiation on Transformation of Human Breast Epithelial Cells. In: Medina, D., Kidwell, W., Heppner, G., Anderson, E. (eds) Cellular and Molecular Biology of Mammary Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0943-7_22
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0943-7_22
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-42761-9
Online ISBN: 978-1-4613-0943-7
eBook Packages: Springer Book Archive