Abstract
This chapter discusses the basic physical principles and technical concepts of radiation detectors, and SPECT and PET scanners. The aim is to provide the reader with an understanding of these modalities; in particular, how the signal is created and how it is detected. Since the interaction of radiation with matter is the basis for radioactivity detection, the mechanisms of excitation, ionization, photoelectric effect and Compton scattering are briefly discussed. The technical description is provided in combination with the current state of the art in imaging instrumentation to illustrate the advantages and disadvantages of planar, SPECT and PET imaging modalities. The differences in PET and SPECT scanner performance characteristics (such as spatial resolution and sensitivity) and their relationship to radionuclide emissions (% abundance and the energy of radiation) are briefly summarized. Finally, the technical features of small animal imaging scanners, μPET and μSPECT in the assessment of molecular imaging probes in animal models, are also briefly explained.
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Keywords
- Single Photon Emission Compute Tomography
- Positron Emission Tomography Image
- Positron Emission Tomography Scanner
- Cadmium Zinc Telluride
- National Electrical Manufacturer Association
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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(2009). PET and SPECT Scanners. In: Molecular Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76735-0_6
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DOI: https://doi.org/10.1007/978-3-540-76735-0_6
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