Abstract
One of the important requirements of molecular imaging based on PET and SPECT techniques is the quantitative measurement of regional radiotracer activity in order to assess the local physiological and biochemical function. Some of the basic principles and concepts involved in quantitative methods will be described in this chapter. With PET studies, the standard uptake value (SUV) determination is regarded as a semiquantitative method since it does not take into account many of the biochemical processes. The measured time-activity distribution, however, is influenced by various factors such as blood flow, clearance from plasma, the number of specific and nonspecific binding sites, and their affinity. Tracer kinetic physiologic models describe the transfer and behavior of the radiotracer mathematically between compartments, each of which represents distinct anatomic, physiologic, or biochemical space, such as extracellular, intracellular and receptor bound. A brief overview of compartmental modeling, quantitative parameter estimation, and graphical analysis of radiotracer interaction with enzymes and receptor systems is presented with specific examples.
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(2009). Pharmacokinetics and Modeling. In: Molecular Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76735-0_14
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DOI: https://doi.org/10.1007/978-3-540-76735-0_14
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