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Lectins of the ER Quality Control Machinery

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Mammalian Carbohydrate Recognition Systems

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 33))

Abstract

Calnexin was first identified as a type I transmembrane phosphoprotein located in the endoplasmic reticulum (ER; Wada et al. 1991). In subsequent work, this protein has been shown to belong to a new family of chaperones or proteins with lectin-like properties with orthologs present in all eukaryotes so far studied (Wada et al. 1991; Hebert et al. 1995). Calnexin and calreticulin, an ER luminal homologue, share extensive sequence similarity and both bind calcium.

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Abbreviations

CNX:

calnexin

CRT:

calreticulin

CPY:

carboxypeptidase Y

CK2:

casein kinase 2

ER:

endoplasmic reticulum

UGGT:

UDP-glucose glycoprotein glucosyltransferase

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, McGill University, Montreal, QC, H3A 2B2, Canada

    E. Chevet & J. J. M. Bergeron

  2. Genetics Group, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada

    E. Chevet

Authors
  1. C. A. Jakob
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  2. E. Chevet
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  3. D. Y. Thomas
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  4. J. J. M. Bergeron
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Editors and Affiliations

  1. The Wellcome Trust Building, Dept. of Biochemistry, University of Dundee, DD1 4HN, Dundee, Scotland

    Paul R. Crocker

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© 2001 Springer-Verlag Berlin Heidelberg

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Jakob, C.A., Chevet, E., Thomas, D.Y., Bergeron, J.J.M. (2001). Lectins of the ER Quality Control Machinery. In: Crocker, P.R. (eds) Mammalian Carbohydrate Recognition Systems. Results and Problems in Cell Differentiation, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46410-5_1

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  • DOI: https://doi.org/10.1007/978-3-540-46410-5_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-53670-0

  • Online ISBN: 978-3-540-46410-5

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