Abstract
This chapter reviews the underlying physical principles of single-photon emission tomography (SPECT) and the design and operation as well as the capabilities and limitations of current SPECT scanners.
Similar content being viewed by others
Abbreviations
- ACF:
-
Attenuation correction factor
- APD:
-
Avalanche photodiode
- ASIC:
-
Application-specific integrated circuit
- COR:
-
Center of rotation
- CsI(Tl):
-
Thallium-doped cesium iodide
- CT:
-
X-ray computed tomography
- CZT:
-
Cadmium zinc telluride
- ESSE:
-
Effective scatter source estimation
- eV:
-
Electron volt
- FBP:
-
Filtered back-projection
- FL:
-
Focal length
- FOV:
-
Field of view
- FWHM:
-
Full-width half-maximum
- GAP:
-
General all-purpose
- keV:
-
Kilo-electron volt (103 eV)
- LEAP:
-
Low-energy all-purpose
- LEHR:
-
Low-energy high-resolution
- LEHS:
-
low-energy high-sensitivity
- LOR:
-
Line of response
- MeV:
-
Mega-electron volt (106 eV)
- MR:
-
Magnetic resonance
- MRI:
-
Magnetic resonance imaging
- NaI(Tl):
-
Thallium-doped sodium iodide
- PET:
-
Positron emission tomography
- PET/CT:
-
Positron emission tomography/computed tomography
- PET/MR:
-
Positron emission tomography/magnetic resonance
- PMT:
-
Photomultiplier tube
- RF:
-
Radiofrequency
- ROI:
-
Region of interest
- SAD:
-
Source-to-aperture distance
- SPECT:
-
Single-photon emission computed tomography
- SPECT/CT:
-
Single-photon emission computed tomography/computed tomography
- SPECT/MR:
-
Single-photon emission computed tomography/magnetic resonance
- TEW:
-
Triple-energy window
References
Cherry SR, Sorenson JA, Phelps ME. Physics in nuclear medicine. 4th ed. Philadelphia, PA: Saunders; 2012.
Zanzonico PB. Technical requirements for SPECT: equipment and quality control. In: Kramer EL, Sanger JJ, editors. Clinical applications in SPECT. New York, NY: Raven Press; 1995. p. 7–41.
Zanzonico P. Radionuclide imaging. In: Cherry S, Badawy R, Qi J, editors. Essentials of in vivo biomedical imaging. Boca Raton, FL: CRC Press; 2015. p. 1765–224.
Zanzonico P. Instrumentation for single-photon emission computed tomography. In: Strauss HW, Mariani G, Volteranni G, Larson SM, editors. Nuclear oncology: from pathophysiology to clinical applications. 2nd ed. New York, NY: Springer; 2017.
Travin MI. Cardiac cameras. Semin Nucl Med. 2011;41:182–201.
Slomka PJ, Berman DS, Germano G. New cardiac cameras: single-photon emission CT and PET. Semin Nucl Med. 2014;44:232–51.
Slomka PJ, Pan T, Berman DS, et al. Advances in SPECT and PET hardware. Prog Cardiovasc Dis. 2015;57:566–78.
Frey EC, Humm JL, Ljungberg M. Accuracy and precision of radioactivity quantification in nuclear medicine images. Semin Nucl Med. 2012;42:208–18.
Tsui BM, Zhao X, Frey EC, et al. Quantitative single-photon emission computed tomography: basics and clinical considerations. Semin Nucl Med. 1994;24:38–65.
Dewaraja YK, Frey EC, Sgouros G, et al. MIRD pamphlet No. 23: quantitative SPECT for patient-specific 3D dosimetry in internal radionuclide therapy. J Nucl Med. 2012;53:1310–25.
Ljungberg M, Pretorius PH. SPECT/CT: an update on technological developments and clinical applications. Br J Radiol. 2018;90:1–15.
Wu J, Liu C. Recent advances in cardiac SPECT instrumentation and imaging methods. Phys Med Biol. 2019;64:1–37.
Hamamura MJ, Ha S, Roeck WW, et al. Development of an MR-compatible SPECT system (MRSPECT) for simultaneous data acquisition. Phys Med Biol. 2010;55:1563–75.
Hamamura MJ, Ha S, Roeck WW, et al. Initial investigation of preclinical integrated SPECT and MR imaging. Technol Cancer Res Treat. 2010;9:21–8.
Ha S, Hamamura MJ, Roeck WW, et al. Development of a new RF coil and gamma-ray radiation shielding assembly for improved MR image quality in SPECT/MRI. Phys Med Biol. 2010;55:2495–504.
Hamamura MJ, Roeck WW, Ha S, et al. Simultaneous in vivo dynamic contrast-enhanced magnetic resonance and scintigraphic imaging. Phys Med Biol. 2011;56:N63–9.
Wright CL, Zhang J, Tweedle MF, Knopp MV, Hall NC. Theranostic imaging of yttrium-90. BioMed Res Int. 2015;2015:1–11.
Firestone RB, Shirley VS (Eds). Table 11 of isotopes. 8th ed. New York, NY: John Wiley & Sons; 1996.
Eckerman KF, Endo A. MIRD: radionuclide data and decay schemes. 2nd ed. Reston, VA: Society of Nuclear Medicine; 2008.
Saha GS. Physics and radiobiology of nuclear medicine. New York, NY: Springer; 1993. p. 107–23.
Zanzonico P. Routine quality control of clinical nuclear medicine instrumentation: a brief review. J Nucl Med. 2008;49:1114–31.
Greer K, Jaszczak RJ, Harris C, et al. Quality control in SPECT. J Nucl Med Technol. 1985;13:76–85.
Harkness BA, Rogers WL, Clinthorne NH, et al. SPECT: quality control and artifact identification. J Nucl Med Technol. 1983;11:55–60.
Ogawa K, Harata Y, Ichihara T, et al. A practical method for position-dependent Compton-scatter correction in single photon-emission CT. IEEE Trans Med Imaging. 1991;10:408–12.
Frey EC, Tsui B. A new method for modeling the spatially-variant, object-dependent scatter response function in SPECT. IEEE Trans Med Imaging. 1996;2:1082.
Beekman FJ, de Jong HW, van Geloven S. Efficient fully 3-D iterative SPECT reconstruction with Monte Carlo-based scatter compensation. IEEE Trans Med Imaging. 2002;21:867–77.
Dewaraja YK, Ljungberg M, Fessler JA. 3-D Monte Carlo-based scatter compensation in quantitative I-131 SPECT reconstruction. IEEE Trans Nucl Sci. 2006;53:181–8.
Ouyang J, El Fakhri G, Moore SC. Improved activity estimation with MC-JOSEM versus TEW-JOSEM in 111In SPECT. Med Phys. 2008;35:2029–40.
Chang LT. A method for attenuation correction in radionuclide computed tomography. IEEE Trans Nucl Sci. 1978;25:638–43.
Sorenson JA. Quantitative measurement of radioactivity in whole-body counting. In: Hine GJS, editor. Instrumentation of nuclear medicine. Waltham, MA: Academic Press; 1974. p. 311–48.
Israel O, Goldsmith SJ (Eds). Hybrid SPECT/CT: imaging in clinical practice. New York, NY: Taylor & Francis; 2006.
Hoffman EJ, Huang SC, Phelps ME. Quantitation in positron emission computed tomography: 1. Effect of object size. J Comput Assist Tomogr. 1979;3:299–308.
Erlandsson K, Buvat I, Pretorius PH, Thomas BA, Hutton BF. A review of partial volume correction techniques for emission tomography and their applications in neurology, cardiology and oncology. Phys Med Biol. 2012;57:R119–59.
Lyra M, Ploussi A. Filtering in SPECT image reconstruction. Int J Biomed Imaging. 2011;2011:1–14.
NEMA. Performance measurements of scintillation counters. NEMA standards publication NU1-2001. Rosslyn, VA: National Electrical Manufacturers Association (NEMA); 2001.
Flux G, Bardies M, Monsieurs M, et al. The impact of PET and SPECT on dosimetry for targeted radionuclide therapy. Z Med Phys. 2006;16:47–59.
Imbert L, Poussier S, Franken PR, et al. Compared performance of high-sensitivity cameras dedicated to myocardial perfusion SPECT: a comprehensive analysis of phantom and human images. J Nucl Med. 2012;53:1897–903.
Van den Wyngaert T, Elvas F, De Schepper S, Kennedy JA, Israel O. SPECT/CT: standing on the shoulders of giants: it is time to reach for the sky. J Nucl Med. 2020;61:1284–91.
Shcherbinin S, Celler A, Belhocine T, et al. Accuracy of quantitative reconstructions in SPECT/CT imaging. Phys Med Biol. 2008;53:4595.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this entry
Cite this entry
Zanzonico, P. (2022). Instrumentation for Single-Photon Emission Computed Tomography (SPECT). In: Volterrani, D., Erba, P.A., Strauss, H.W., Mariani, G., Larson, S.M. (eds) Nuclear Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-26067-9_5-2
Download citation
DOI: https://doi.org/10.1007/978-3-319-26067-9_5-2
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-26067-9
Online ISBN: 978-3-319-26067-9
eBook Packages: Springer Reference MedicineReference Module Medicine
Publish with us
Chapter history
-
Latest
Instrumentation for Single-Photon Emission Computed Tomography (SPECT)- Published:
- 10 April 2022
DOI: https://doi.org/10.1007/978-3-319-26067-9_5-2
-
Original
Instrumentation for Single-Photon Emission Imaging- Published:
- 07 October 2016
DOI: https://doi.org/10.1007/978-3-319-26067-9_5-1