Abstract
Historically anticoagulation involved the use of heparin and its derivatives or warfarin. However, the past few years have seen the introduction of a number of novel direct oral anticoagulants. These drugs are of interest as they require no laboratory monitoring, are relatively easy to use as they have a fixed dose and have demonstrated equivalence and in some cases superiority to warfarin, in the prevention of cardioembolic stroke in individuals with non-valvular atrial fibrillation, in deep vein thrombosis (DVT) prevention in patients undergoing hip and knee replacement surgery and in the treatment of DVT and pulmonary embolism (PE).
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Keywords
- International Normalize Ratio
- Activate Partial Thromboplastin Time
- Dabigatran Etexilate
- Systemic Embolism
- Knee Replacement Surgery
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References
Biss TT, Avery PJ, Brandao LR, et al. VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children. Blood. 2012;119:868-873.
Gong IY, Tirona RG, Schwarz UI, et al. Prospective evaluation of a pharmacogeneticsguided warfarin loading and maintenance dose regimen for initiation of therapy. Blood. 2011;118:3163-3171.
Darghouth D, Hallgren KW, Shtofman RL, et al. Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor deficiency. Blood. 2006;108:1925-1931.
SPC D. Dabigatran SPC. 2015.
SPC R. Rivaroxaban SPC. 2015.
Hamberg AK, Dahl ML, Barban M, et al. A PK-PD model for predicting the impact of age, CYP2C9, and VKORC1 genotype on individualization of warfarin therapy. Clin Pharmacol Ther. 2007;81:529-538.
Baron TH, Kamath PS, McBane RD. Management of antithrombotic therapy in patients undergoing invasive procedures. N Engl J Med. 2013;368:2113-2124.
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Perry, D. (2016). Overview of anticoagulants. In: Perry, D., Warwick, D. (eds) Handbook of Thromboprophylaxis. Adis, Cham. https://doi.org/10.1007/978-3-319-21148-0_2
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DOI: https://doi.org/10.1007/978-3-319-21148-0_2
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