Abstract
The 1,2-diamine (vicinal diamine) functionality is a remarkable template which displays a broad spectrum of biological activity. For the purpose of this review, molecules possessing two nitrogen atoms separated by two carbon atoms, at least one of which being sp3-hydridized, will be considered to be 1,2-diamines. Structural units such as piperazine and imidazolidine will be included as examples of 1,2-diamines. The 1,2-diamine conformation may be found in many important compounds including antiarrhythmics, antihypertensives, antipsychotics, analgesics, antianxiety agents, local anesthetics, anticonvulsants, gastrointestinal agents, anticancer drugs, and antiparasitic agents. The number of compounds falling into the 1,2-diamine category as defined above is considerable. Consequently, this review is intended to be illustrative rather than exhaustive.
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© 1989 Birkhäuser Verlag Basel
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Michalson, E.T., Szmuszkovicz, J. (1989). Medicinal agents incorporating the 1,2-diamine functionality. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 33. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9146-2_6
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DOI: https://doi.org/10.1007/978-3-0348-9146-2_6
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