Abstract
Recognition, evaluation, and management of foot and ankle stress fractures are key, especially in an athletic population as it can cause long absences from performance. These can present in all bones of the human body, but they appear to be more common in the lower limb, especially over foot and ankle.
Therefore, a high index of suspicion without delay in further investigation is mandatory in the athlete. Additionally, treatment consists mostly of activity modification and relative rest.
Surgery can be indicated in case of a “high-risk” fracture pattern that is potentially prone to diastasis and/or displacement.
This chapter focuses on the specific foot and ankle stress fractures in athletes and presents the evidence-based clinical examination pearls and best management for an early and safe return to play.
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1 Introduction
A stress fracture is a partial or complete disruption of bone continuity, representing the inability of the skeleton to withstand repetitive submaximal loading, which results in structural fatigue, and resultant signs and symptoms of localized pain and tenderness [1].
Although stress fractures are rare, they can present as common overuse injuries, leading to fatigue fractures (gradual onset—overload injury; high recurrence) in physically active individuals like athletes and military recruits [2]. These injuries are associated with a prolonged absence from sports [3, 4] and can potentially be career-ending [5]. In addition, stress fractures have a high rate of recurrence (22%) and often present as a competition season-ending injury (20%) [6].
This chapter aims at outlining the most common stress fractures of the ankle and foot with focus on the initial management by means of clinical examination. It also provides diagnostic, therapeutical, and return-to-play guidelines for these types of injuries.
2 Epidemiology
Stress fractures are rare, but they most commonly occur in athletes who are usually exposed to highly repetitive weight-bearing activities and they can lead to long absences from sports.
There is a lack of evidence-based epidemiologic data among studies regarding the rate of stress fractures in recreational or competitive athletes, ranging from 0.5% to 4.8% of all injuries in multiple sports [7]. The incidence of stress fractures in military recruits is higher when comparing to athletes and varies from 5% to 30% per year, being higher in female recruits [8,9,10,11].
According to Ekstrand et al. [12], in elite male football (soccer) players, stress fractures represent only 0.5% of all injuries, giving an injury incidence of 0.04 injuries/1000 h (a team of 25 players can expect one stress fracture every third season), but the median absence from sports is high—80 days (3 months).
It seems that the injury rate among females is higher when compared to males due to the specific physiopathogenesis of the female athlete triad [13]. According to Rizzone et al.’s study [6] in collegiate student-athletes, the ratio of female/male was 2.5–3 to 1. There are some sports in which stress fractures are more common such as running, gymnastics, ballet, football (soccer), and figure skating [14].
It is also known that younger players are more likely to develop stress fractures in comparison to older players and they also have a higher reinjury rate (29%) [12].
Anatomically, all bones of the human body can be subjected to stress fractures, but there is a clear predominance over the lower limbs, especially over the weight-bearing bones [15].
The most common locations for stress fractures are the metatarsals (fifth and second), tibia (anterior cortical bone), femoral neck (superolateral), ribs, medial and lateral malleolus, talus, calcaneus, navicular, cuboid, patella, sesamoids (hallux), pelvis (ischiopubic rami), sacrum, and pars interarticularis. According to Matheson et al. [16] in a study of 320 athletes, the tibia (49.1%), tarsals (25.3%), and metatarsals (8.8%) were the most frequently involved bones affected by a stress fracture (Fig. 71.1). Certain anatomical sites are specific of certain sports [17].
3 Etiopathogenesis and Mechanism of Injury
The exact pathophysiology of stress fractures is unknown. Bone is a dynamic tissue, and its turnover cycle, remodeling, and mineralization phases generally require a period of 3–4 months.
The applied bony load during sports activities or weight-bearing activities results in external forces (strain) and internal forces (stress) [18], both of which are vital for the maintenance of the normal bony strength. Stress fractures occur when there is an imbalance between the bone that is formed and the bone that is remodeling. This will consequently result in a progressive discontinuity of the bone, and eventually, the bone becomes unable to resist repetitive (cyclic) loads. It can also be explained by an imbalance between the strength of the bone itself (bone resistance) and chronic mechanical overload (forces of tension and compression/impact) on the bone that makes it unable for the bone to deform and absorb these forces (repetitive loading), exceeding the range of normal bone elasticity.
Stress fractures can be divided (according to the bone quality and load) into fatigue fractures (in those that result from an increase load/cyclic forces on a normal bone like a high volume of exercises in a short period of time) and insufficiency fractures, produced by normal load within weakened bones (i.e., osteoporosis/osteomalacia).
However, not only the bone pathophysiology and biomechanical factors are involved, but also hormonal, nutritional, and genetic factors. Other intrinsic and extrinsic risk factors are detailed in Table 71.1.
It is important to identify these risk factors and target these groups in order to prevent and anticipate the occurrence of stress fractures.
4 Diagnosis
4.1 Clinical Assessment and Physical Examination
A detailed clinical assessment and a focused physical examination with a presumptive clinical suspicion are key for a correct non-delayed diagnosis of a stress fracture.
Most of the patients have an insidious and progressive onset of mild pain with no history of trauma. The pain is aggravated with repeated weight-bearing activities and is relieved by rest. However, many athletes with stress fractures can present asymptomatic. It is critical to have a high index of suspicion on the presence of predisposing risk factors since many athletes with complaints may present with normal radiographs. A complete history should include detailed questions on diet, nutrition, medication, daily activities, training schedule, equipment/footwear, training surface, menstrual cycle, and external load. Ask if something has changed, regarding training load, coach and/or staff, footwear, or surface.
In females, it is mandatory to evaluate gender-specific risk factors such as menstrual disorders, eating disturbances, and recent weight loss.
The physical examination should assess limb alignment, length discrepancies, gait, muscular asymmetry, active and passive range of motion, abnormalities of the plantar arch, callosities (repetitive stress in a focal area), fixed or flexible deformities, and laxity or stiffness.
Usually, tenderness on palpation or percussion of the involved bone is found, and sometimes it is possible to palpate a periosteal thickening (sign of inadequate callus formation), especially in chronic stress fractures with delayed union. Swelling, erythema, ecchymosis, and warmth may also be apparent. If the pain increases with passive inversion stretch, you should look for a fifth metatarsal stress fracture. In the case of a calcaneus stress fracture, the pain should increase with a calcaneal squeeze test (Fig. 71.2).
The hop test (Fig. 71.3) should be performed to rule out foot and ankle stress fractures. This test consists of hop up and down on the affected limb several times barefoot. A large amount of pain in a localized area of the lower extremity is a positive test and may signify a fracture.
Cavovarus foot alignment and pain upon tiptoe standing can also be suspicious.
Fact Box 1
Always suspect a stress fracture in an athlete who presents with dull foot pain, localized to the bone, that increases on activity and is relieved with rest.
4.2 Imaging
Radiographic imaging is considered critical for the diagnosis, prognosis, and follow-up of stress fractures.
4.2.1 Radiography
Radiographs are considered the initial imaging modality in stress fractures due to their easy access and relatively low cost. Plain weight-bearing anteroposterior, lateral, and oblique radiographic views are the current standard.
Although radiographs have a high specificity, they are not always reliable and can be missed (up to 87% false-negative rate), particularly during the initial 2–3 weeks after the onset of symptoms [20, 21]. Most fractures are incomplete, which makes them invisible on plain radiographs until bony osteoclastic resorption has taken place [22].
The earliest stress fracture sign on radiographs is a localized periosteal thickening or a subtle radiolucent area. Especially at later stages in the stress fracture development, periosteal reaction and callus formation will appear (Fig. 71.4). In the absence of positive radiographic findings and a high index of stress fracture suspicion, further imaging should be considered by means of magnetic resonance imaging (MRI), computed tomography (CT), or bone scan.
Fact Box 2
Do not rely on plain radiographs only for the diagnosis of foot stress fractures. MRI, CT scan, and/or bone scan are often required for diagnostic confirmation.
4.2.2 Ultrasonography
Ultrasound is a sensitive diagnostic tool and easily accessible and can identify early bony stress reaction. In case of a normal radiograph, it is advised to ask for an ultrasound to identify periosteal reaction as a primary sign of the bony stress reaction. Although previously thought to have a poor sensitivity and specificity, a recent trial found increased pain to have a positive predictive value of 99% (sensitivity, 81.9%; specificity, 66.6.%) in the application of therapeutic ultrasound at the site of a bony stress injury [23].
4.2.3 CT Scan
Computed tomography (CT) scan can be helpful to highlight a small fracture line, can confirm the diagnosis of a complete stress fracture, and can also be used to monitor healing (Fig. 71.5). This modality can also be useful when there is a contraindication for the use of magnetic resonance imaging (MRI) or in chronic cases (where it is shown to be more useful than MRI or bone scan).
4.2.4 MRI
Magnetic resonance imaging (MRI) is the most sensitive and specific imaging modality for the diagnosis of stress fractures, and it is currently considered the golden standard [24].
The abnormalities caused by the fracture can usually be identified 1–2 days after the start of symptoms, with an early detection of bony edema [25,26,27].
MRI can differentiate medullary damage from the cortical, endosteal, and periosteal bone, allowing it to formulate a severity and prognosis staging (Table 71.2). MRI can also accurately delineate the exact anatomic location and the extent of the stress injury (by detecting bone edema and changes in cortical density), but it remains important to correlate the radiological images with the patient’s clinical findings. In a study involving 21 asymptomatic runners [28], 43% presented with bone edema on MRI suggesting a potential stress fracture because athletes are subjected to repetitive microtrauma during endurance running.
It is important to highlight MRI as the imaging modality of choice in the detection of pre-fracture stages with bone edema (Fig. 71.6) and stress reaction, but MRI is shown to be inferior to CT scan in the identification of the stress fracture itself.
When a stress fracture is clinically suspected, the initial imaging modality should be CT scan in order to visualize the fracture line. If the CT scan does not demonstrate any signs of fracture, an MRI is the next appropriate imaging modality to determine whether a stress reaction is occurring.
4.2.5 Bone Scan (Scintigraphy)
A bone scan has a high sensitivity but low specificity and should not be used as a first-line imaging modality in bony stress fractures. However, a bone scan can be helpful when CT and/or MRI fail to demonstrate a clear diagnosis. In case of a stress fracture, the bone scan can present with positive signs in all three phases, in contrast to soft-tissue injuries where it can only hypercaptate during the first injury phase.
5 General Treatment Concepts
Although there are no evidence-based guidelines supported by literature regarding best treatment, below is a summary of the current treatment options.
5.1 Conservative Treatment
Most nonoperative treatment strategies should include decrease in physical activity and training load, avoidance of pain-related activities and relative weight-bearing restriction, or immobilization. Pain control with oral analgesic medications (NSAIDs should be avoided), cold therapy, proper rehabilitation, and a personalized conditioning alternative physical program is recommended (minimal impact aerobic activities to maintain flexibility and strength; consider using antigravity treadmill). Other modalities of nonoperative treatment can be described below:
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Biomechanical therapy
The major components in the treatment of any stress fracture are “rest” and “activity modification.” Especially during in-season, a team approach (medical staff, coach, agent, director) is key in the management of setting up treatment goals and return-to-play criteria. Although this sometimes means to temporarily unload and immobilize a player/athlete, cycling, rowing, swimming, and even specific running (to maintain cardiovascular fitness and lower limb strength) can be continued. The focus should be on altering the nature of the training, individualizing the program, and type of surface and shoe. Hydrotherapy and antigravity treadmill are useful in this stage to keep the player’s fitness while allowing the stress fracture to heal. Careful evaluation of malalignment, muscular imbalance, and abnormal loading patterns need to be assessed and corrected meanwhile.
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Biological therapies
Several adjuvant treatment strategies, such as bone morphogenic protein (BMP), bisphosphonates, teriparatide, and hyperbaric oxygen, have been recommended in literature to enhance stress fracture healing. Controversy remains due to the heterogeneity of patient populations, the interventions offered, as well as the different outcome measures considered. In addition, most of the published reports are case series. We did not find any evidence regarding platelet-rich plasma (PRP) injections for stress fracture treatment.
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Extracxorporal Shock-wave therapy (ESWT)
ESWT can have a role in the upregulation of local angiogenesis and concentration of growth factors. Although quality research is lacking, ESWT has shown improved healing potential and earlier return to play in chronic and nonunion cases [30, 31].
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Low-intensity pulsed ultrasound therapy (LIPUS)
LIPUS has been introduced as a promising alternative to treat nonunion or delayed union. A recent systematic review however concluded that LIPUS does not reduce the time to return to activity for conservatively treated stress fractures [32].
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Electrical stimulation (ES)
There is laboratory evidence that endochondral bone formation and growth factor expression may be appropriately stimulated by the application of an electromagnetic field. Electrical stimulation (ES) therapy can be provided via several modes: direct current, capacitative coupling, inductive coupling, and pulsed electromagnetic field. Although in football for example the pressure can be high to try out these “new tools,” there is little evidence for the use of ES in the management of stress fractures [33].
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Bone morphogenic proteins (BMPs)
BMPs belong to “transforming growth factor b superfamily proteins” and act as osteoinductive agents to enhance fracture healing. Several BMPs have been isolated like BMP-2 and BMP-7 that are subjected to clinical trials. In stress fractures, there is no evidence to support the use of BMPs [33].
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Teriparatide
Teriparatide is a bone anabolic agent (recombinant human parathyroid hormone analogue) used in the treatment of osteoporosis by stimulating osteoblasts. A recent RCT showed that it can shorten the time to fracture healing compared to placebo, but no credible data in stress fractures is available yet [34].
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Vitamin D
In football, there is a growing awareness of the importance of the role of vitamin D levels, particularly in Northern Europe (even the elite players), with several studies showing hypovitaminosis (some among the lowest levels), especially in wintertime [35].
5.2 Surgical Treatment
Stress fractures can be classified as “low risk” or “high risk,” and this can influence the proper decision-making (Table 71.3). High-risk fractures are prone to displacement, delayed union, and nonunion. In case of nonoperative treatment, they require a prolonged period of healing and can potentially become career-ending.
In patients with “high-risk” stress fracture sites or displaced fractures (especially in athletes), early surgical fixation is preferred due to a high rate of biological failure, extended healing time, nonunion, and possibility of refracture [36,37,38].
6 Site-Specific Stress Fractures
According to a stress fracture study in 2379 elite male football players [12], all fractures (51) were noted in the lower extremities: the most common site was the fifth metatarsal (78%); 12% were in tibia and 6% in the pelvis. Twenty-nine percent of those stress fractures were reinjuries.
Additionally, it is important to be aware of “high-risk” stress fracture sites such as fifth metatarsal (zone 3—metaphysio-diaphyseal junction); talar neck; femoral neck; patella; anterior tibial diaphysis; medial malleolus; navicular; sesamoids of the hallux; and neck of the second to fourth metatarsals. These site-specific stress fractures are prone to complications such as displacement, delayed and nonunion, or prolonged specific treatment management requirements. “Low-risk” stress fracture sites are the posteromedial tibial shaft, metatarsal shaft, distal fibula, medial femoral neck, femoral shaft, and calcaneus and often heal with a proper diagnosis and treatment (Table 71.3).
6.1 Metatarsal Stress Fractures
The metatarsal area is a common site for developing stress fractures [5]. Stress fractures of the fifth and the second metatarsals (MT) are more common than the rest. Because of its unique anatomy and function, it is conventional to group MT fractures into fractures of the medial column (first MT), central column (second–third MT), and lateral column (fourth–fifth MT).
Fact Box 3
Always enquire about changes in the training schedule and playing surface since these are important risk factors in football particularly.
6.1.1 Fifth Metatarsal Stress Fractures
Fractures of the base of the fifth metatarsal have been classified into three zones according to Lawrence and Botte [39], with each zone representing a different mechanism of injury, treatment strategy, and prognosis (Fig. 71.7). Zone 1 (tuberosity area) is associated with avulsion fractures; zone 2 (tuberosity—metaphyseal area) is the so-called Jones fracture; and zone 3 (metaphyseal-diaphyseal area) represents true stress fractures and involves the junction of the metaphysis and diaphysis of the fifth metatarsal. Zones 2 and 3 are predisposed to delayed healing due to a vascular watershed zone between the insertion of peroneus brevis and the diaphyseal blood supply.
Surgical strategies include percutaneous, mini-open, and open reduction and internal fixation techniques with intramedullary screw fixation, bone grafting, and tension band wiring (by means of a metal cerclage or a novel high-resistance suturing method) (Fig. 71.8) [40]. In addition, some authors have advocated adding bone marrow aspirate concentrate (BMAC) to improve the biological environment and healing potential of the fracture.
A recent systematic review from Mallee et al. [41] showed proven benefit of surgical management, in terms of return to sport. Conservative management varies from limitations of activities to non-weight-bearing cast immobilization and remains a valid option for the recreational athlete.
Especially for fifth metatarsal Torg type II and III fractures (Table 71.4) and for stress fractures displaced more than 2 mm, surgery is recommended [42, 43]. A 5.5 mm partially threaded cannulated screw is the current golden standard for fixation although good results are reported with headless compression screws also [44]. It is recommended to use the largest diameter screw that fits the width of the intramedullary canal with a minimum diameter of 4 mm, and with sufficient screw length, covering the fracture (Fig. 71.9) with threads jutting beyond the fracture site in order to generate maximum compression [45, 46].
Refractures after the surgical treatment of fifth metatarsal stress fractures can be as high as 10–30% in some series. They are found to be associated with increased body weight and zone 2–3 Torg-type fractures in the hypo-vascularized metatarsal stress fracture zone.
Postoperatively, a non-weight-bearing short leg cast or plaster splint for 1–2 weeks is started, followed by a controlled ankle movement walker boot for 2 more weeks [47]. After 6–8 weeks postoperatively, full weight-bearing is allowed and normal activities can be resumed.
6.1.2 Second Metatarsal Stress Fractures
Among the metatarsal bones, the second is known to be the most commonly injured, followed by the third, base of the fifth, fourth, and first metatarsal [3, 48]. Stress fractures of the proximal second metatarsal are most commonly observed in female ballet dancers, due to the “en pointe” position. They are also frequently encountered in runners, due to the high-force vector that is transmitted through the meta-diaphyseal region, leading to a high metatarsal bending stress. Although no direct link with a specific forefoot morphology has been reported, a shorter and hypermobile first metatarsal or a longer second metatarsal is hypothesized to be a risk factor for these stress fracture types [3, 49, 50]. Clinically, these second metatarsal base fractures can be very difficult to differentiate from Lisfranc joint synovitis. They are also at high risk for delayed union and may significantly affect the athlete’s ability to return to elite level.
Distal fractures have a good prognosis and a relatively fast recovery through nonoperative management. In these patients, relative rest and partial to full weight-bearing in a CAM boot are recommended.
6.2 Navicular Stress Fractures
Stress fractures of the tarsal navicular account for up to 35% of all foot and ankle stress fractures [51]. Navicular fractures are typically seen in track and field athletes, especially sprinting athletes, professional tennis players, jumpers, and athletes engaging in explosive push-off activities [52].
Navicular stress fractures are considered at high risk for delayed union or nonunion, due to the relatively poor vascular supply in the central third of the bone [53]. However, nonoperative treatment in a non-weight-bearing plaster cast or boot for 5 weeks followed by 4–6 weeks of rehabilitation is still recommended for the general population [54,55,56,57,58]. In case of displaced fractures, delayed union, or nonunion, surgery can be indicated [24, 59].
Currently, there is no evidence-based consensus on best therapeutic strategies in the athletic population.
According to Saxena’s classification [58], nonoperative treatment should be advised in type 1 fractures (dorsal cortex-only involvement) and surgery in type 2 (propagation of the fracture into the navicular body) and type 3 (bicortical disruption) fractures.
Usually, surgical internal fixation involves the use of two partial-threaded cannulated screws placed lateral to medial in a parallel or cross configuration.
6.3 Medial Malleolus Stress Fractures
Medial malleolus stress fractures are relatively uncommon. They account for 0.6–4.1% of all stress fractures [51, 60]. They typically occur in high-level runners and jumpers. Stress fractures of this anatomical site seem to be due to repetitive impingement of the talus on the medial aspect of the distal tibia during forced dorsiflexion of the ankle [48].
The treatment of medial malleolus stress fractures varies depending on fracture propagation, displacement, athletic level, and seasonal timing. In case of a clear fracture line or displacement (especially in elite and “in-season” athletes), surgical internal fixation is recommended [61,62,63,64,65].
6.4 Other Stress Fractures of the Foot
6.4.1 Calcaneus
Calcaneal stress fractures are rare, and most studies report on the occurrence of these fractures in army recruits rather than in athletes. The diagnosis is often delayed due to similarity of symptoms with plantar fasciitis, retrocalcaneal bursitis, Achilles tendinitis, Baxter’s nerve disorder, and Sever’s disease. The typical presentation is localized tenderness at the heel and/or with positive calcaneal compression test, which increases with activity and is relieved with rest/immobilization. At radiographic evaluation, a thin radiolucent or sclerotic line can become apparent, 2–3 weeks after the onset of symptoms. MRI can be a useful tool to identify early bone edema and fracture lines. In most cases, calcaneal stress fractures can be managed with nonoperative treatment and activity modification.
6.4.2 Talus
A talar stress fracture is a relatively rare injury but may present in athletes due to repetitive cycles of axial loading activities. The possibility of secondary displacement should be considered. MRI is often required as conventional radiographs are often unable to reveal talar stress fractures (Fig. 71.10).
Despite the lack of a general consensus, undisplaced fractures are often managed nonoperatively by means of 6-week non-weight-bearing cast or boot immobilization. Surgical fixation is indicated in case of secondary displacement, in order to reduce the risk of avascular necrosis [66].
6.4.3 Cuboid
Cuboid stress fractures (Fig. 71.11) are usually treated conservatively with non-weight-bearing with crutches for the initial 2 weeks. Then, when the patient is pain-free, move into protected weight-bearing and then progress into a CAM boot and staged rehabilitation.
The role of podiatry and tailored orthotics is key in treatment and prevention.
6.4.4 Sesamoid
Typically, the medial sesamoid is the most affected by stress fractures. Plain radiographs can be difficult to interpret, and the use of a CT scan is advised in case of clinical suspicion. A bipartite sesamoid may be confused with a fracture but is frequently bilateral (up to 75% of cases) and has smooth edges [66]. Normally, conservative management with rest, boot, orthotics, and progressive loading is standard. In the case where surgery is required, a partial sesamoidectomy is the treatment of choice.
7 Return to Play
The return-to-play decision depends on multiple factors such as the stress fracture localization and pattern, sports activity, severity of the injury, and risk factor modification/control.
Stress fractures can lead to prolonged absences from sports, and the return-to-play process is key to reincorporate the athlete as soon as possible, respecting the biology and healing process.
In case of fifth metatarsal stress fractures, according to Ekstrand and Torstveit [12], the mean absence from football was 3 months and the average time to return to sports is reported to be 24 weeks if conservative treatment is done, and 12 weeks (average time) in case of surgery [67].
For navicular stress fractures, according to Saxena et al., in general population, patients treated conservatively with non-weight-bearing cast last 5.6 months to return to activity while patients treated surgically last 3.8 months to return to activity [58].
In case of medial malleolus stress fractures, 7.6 weeks’ mean time to return to sport has been reported [68], although resolution of symptoms may take 4–5 months [48].
The criteria for allowing an athlete to return to his/her practice can include:
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Absence of pain 10–14 days before starting to do sports activities, during sports movements, and on physical exam
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Formation of bony callus and obliteration of the fracture line on simple radiographs or CT scan imaging support if necessary
In summary, it is important to have clinical and imaging evidence of healing before the athlete fully returns to play.
8 Prevention
Prevention of stress fractures is essential. Gradual training load and monitoring through different training principles/methods, as well as injury prevention programs and risk factor identification and adaptation, are crucial to prevent these injuries. For example, injury prevention programs such as the FIFA 11+ are very important, specially in low-skill-level youth teams [69, 70].
There is limited evidence at present for biological treatment of stress fractures, but biological agents may be useful adjuncts.
Susceptible individuals and risk factors should be identified, modified, and addressed to avoid unnecessary stress fractures. In addition, realistic return-to-play strategies should be implemented from the start.
References
Warden SJ, Creaby MW, Bryant AL, Crossley KM. Stress fracture risk factors in female football players and their clinical implications. Br J Sports Med. 2007;41:i38.
Wright AA, Hegedus EJ, Lenchik L, Kuhn KJ, Santiago L, Smoliga JM. Diagnostic accuracy of various imaging modalities for suspected lower extremity stress fractures. Am J Sports Med. 2016;44(1):255–63.
Mayer SW, Joyner PW, Almekinders LC, et al. Stress fractures of the foot and ankle in athletes. Sports Health. 2014;6(6):481–91.
Miller TL, Jamieson M, Everson S, et al. Expected time to return to athletic participation after stress fracture in division I collegiate athletes. Sports. Health. 2018;10(4):340–4.
Ekstrand J, Van Dijk CN. Fifth metatarsal fractures among male professional footballers: A potential career-ending disease. Br J Sports Med. 2013;47(12):754–8.
Rizzone KH, Ackerman KE, Roos KG, et al. The epidemiology of stress fractures in collegiate student-athletes, 2004-2005 through 2013-2014 academic years. J Athl Train. 2017;52(10):966–75.
Snyder RA, Koester MC, Dunn WR. Epidemiology of stress fractures. Clin Sports Med. 2006;25(1):37–52.
Välimäki VV, Alfthan H, Lehmuskallio E, et al. Risk factors for clinical stress fractures in male military recruits: a prospective cohort study. Bone. 2005;37:267–73.
Milgrom C, Giladi M, Stein M, et al. Stress fractures in military recruits. A prospective study showing an unusually high incidence. J Bone Joint Surg (Br). 1985;67:732–5.
Doral MN, Mann G, Constantini N, et al. Stress fractures: overview. In: Doral MN, Tandoğan RN, Mann G, Verdonk R, editors. Sports injuries. Berlin Heidelberg: Springer; 2012. p. 787–813.
Miller TL, Kaeding CC, Wasserstein D, et al. Pathophysiology and epidemiology of stress fractures. In: Miller TL, Timothy L, Kaeding C, editors. Stress fractures in athletes. New York: Springer; 2014. p. 3–11.
Ekstrand J, Torstveit MK. Stress fractures in elite male football players. Scand J Med Sci Sports. 2012;22(3):341–6.
Torstveit MK, Sundgot-Borgen J. The female athlete triad: are elite athletes at increased risk? Med Sci Sports Exerc. 2005;37(2):184–93.
Astur DC, Zanatta F, Arliani GG, Moraes ER, Pochini Ade C, Ejnisman B. Stress fractures: definition, diagnosis and treatment. Rev Bras Ortop. 2016;51(1):3–10.
Schneiders AG, Sullivan SJ, Hendrick PA, Hones BDGM, Mcmaster AR, Sugden BA, et al. The ability of clinical tests to diagnose stress fractures: a systematic review and meta-analysis. J Orthop Sports Phys Ther. 2012;42(9):760–71.
Matheson GO, Clement DB, McKenzie DC, Taunton JE, Lloyd-Smith DR, Macintyre JG. Stress fractures in athletes: a study of 320 cases. Am J Sports Med. 1987;15:46–58.
Brukner P, Bradshaw C, Khan KM, White S, Crossley K. Stress fractures: a review of 180 cases. Clin J Sport Med. 1996;6:85–9.
Bennell K, Matheson G, Meeuwisse W, et al. Risk factors for stress fractures. Sports Med. 1999;28(2):91–122.
Dhillon MS, Ekstrand J, Mann G, Sharma S. Stress fractures in football. J ISAKOS. 2016;1(4):229–38.
Kaeding CC, Yu JR, Wright R, Amendola A, Spindler KP. Management and return to play of stress fractures. Clin J Sport Med. 2005;15(6):442–7.
Murray SR, Reeder M, Ward T, et al. Navicular stress fractures in identical twin runners: high-risk fractures require structured treatment. Phys Sportsmed. 2005;33(1):28–33.
Mann JA, Pedowitz DI. Evaluation and treatment of navicular stress fractures, including nonunions, revision surgery, and persistent pain after treatment. Foot Ankle Clin. 2009;14(2):187–204.
Papalada A, Malliaropoulos N, Tsitas K, et al. Ultrasound as a primary evaluation tool of bone stress injuries in elite track and field athletes. Am J Sports Med. 2012;40:915–9.
Murray SR, Reeder MT, Udermann BE, et al. High-risk stress fractures pathogenesis, evaluation, and treatment. Comprehen Ther. 2006;32(1):20–5.
Bennell KL, Malcolm SA, Thomas SA, Wark JD, Brukner PD. The incidence and distribution of stress fractures in competitive track and field athletes. A twelve-month prospective study. Am J Sports Med. 1996;24(2):211–7.
Fredericson M, Bergman AG, Hoffman KL, Dillingham MS. Tibial stress reaction in runners. Correlation of clinical symptoms and scintigraphy with a new magnetic resonance imaging grading system. Am J Sports Med. 1995;23(4):472–81.
Sofka CM. Imaging of stress fractures. Clin Sports Med. 2006;25(1):53–62.
Bergman AG, Fredericson M, Ho C, Matheson GO. Asymptomatic tibial stress reactions: MRI detection and clinical follow-up in distance runners. AJR Am J Roentgenol. 2004;183(3):635–8.
Arendt EA, Griffiths HJ. The use of MR imaging in the assessment and clinical management of stress reactions of bone in high-performance athletes. Clin Sports Med. 1997;16(2):291–306.
Moretti B, Notarnicola A, Garofalo R, et al. Shock waves in the treatment of stress fractures. Ultrasound Med Biol. 2009;35(6):1042–9.
Furia JP, Rompe JD, Cacchio A, et al. Shock wave therapy as a treatment of non-unions, avascular necrosis, and delayed healing of stress fractures. Foot Ankle Clin. 2010;15(4):651–62.
Busse JW, Kaur J, Mollon B, et al. Low intensity pulsed ultrasonography for fractures: systematic review of randomised controlled trials. BMJ. 2009;338:b351.
Beck BR, Matheson GO, Bergman G, et al. Do capacitively coupled electric fields accelerate tibial stress fracture healing? A randomized controlled trial. Am J Sports Med. 2008;36(3):545–53.
Raghavan P, Christofides E. Role of teriparatide in accelerating metatarsal stress fracture healing: a case series and review of literature. Clin Med Insights Endocrinol Diabetes. 2012;5(5):39–45.
Clutton J, Perera A. Insufficiency and deficiency of vitamin D in patients with fractures of the fifth metatarsal. Foot (Edinb). 2016;27:50.
Volpi P, Ezequiel P, Eran K, et al. Stress fractures of the foot in footballers. In: Football traumatology. New York: Springer; 2005. p. 371–83.
Roche AJ, Calder JD. Treatment and return to sport following a Jones fracture of the fifth metatarsal: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2013;21:1307–15.
Polzer H, Polzer S, Mutschler W, et al. Acute fractures to the proximal fifth metatarsal bone: development of classification and treatment recommendations based on the current evidence. Injury. 2012;43:1626–32.
Lawrence SJ, Botte MJ. Jones’ fractures and related fractures of the proximal fifth metatarsal. Foot Ankle. 1993;14(6):358–65.
D’Hooghe P, Caravelli S, Massimi S, Calder J, Dzendrowskyj P, Zaffagnini S. A novel method for internal fixation of basal fifth metatarsal fracture in athletes: a cadaveric study of the F.E.R.I. technique (fifth metatarsal, extra-portal, rigid, innovative). J Exp Orthop. 2019;6(1):45.
Mallee WH, Weel H, van Dijk CN, van Tulder MW, Kerkhoffs GM, Lin CW. Surgical versus conservative treatment for high-risk stress fractures of the lower leg (anterior tibial cortex, navicular and fifth metatarsal base): a systematic review. Br J Sports Med. 2015;49:370–6.
Torg JS, Balduini FC, Zelko RR, et al. Fractures of the base of the fifth metatarsal distal to the tuberosity. Classification and guidelines for non-surgical and surgical management. J Bone Joint Surg Am. 1984;66(2):209–14.
Logan AJ, Dabke H, Finlay D, et al. Fifth metatarsal base fractures: a simple classification. Foot Ankle Surg. 2007;13(1):30–4.
Nagao M, Saita Y, Kameda S, et al. Headless compression screw fixation of jones fractures: an outcomes study in Japanese athletes. Am J Sports Med. 2012;40(11):2578–82.
Tsukada S, Ikeda H, Seki Y, et al. Intramedullary screw fixation with bone autografting to treat proximal fifth metatarsal metaphyseal-diaphyseal fracture in athletes: a case series. Sports Med Arthrosc Rehabil Ther Technol. 2012;4(1):25.
Ochenjele G, Ho B, Switaj PJ, et al. Radiographic study of the fifth metatarsal for optimal intramedullary screw fixation of Jones fracture. Foot Ankle Int. 2015;36(3):293–301.
Hunt KJ, Goeb Y, Esparza R, et al. Site-specific loading at the fifth metatarsal base in rehabilitative devices: implications for Jones fracture treatment. PM R. 2014;6(11):1022–9.
Brockwell J, Yeung Y, Griffith JF. Stress fractures of the foot and ankle. Sports Med Arthrosc. 2009;17:149–59.
Maitra RS, Johnson DL. stress fractures clinical history and physical examination. Clin Sports Med. 1997;16:260–74.
Gross TS, Bunch RP. A mechanical model of metatarsal stress fracture during distance running. Am J Sports Med. 1989;17:669–74.
Brukner P, Bradshaw C, Khan KM, et al. Stress fractures: a review of 180 cases. Clin J Sport Med. 1996;6:85–9.
Mandell JC, Khurana B, Smith SE. Stress fractures of the foot and ankle, part 2: site-specific etiology, imaging, and treatment, and differential diagnosis. Skelet Radiol. 2017;46:1165–86.
Kaeding CC, Yu JR, Wright R, et al. Management and return to play of stress fractures. Clin J Sport Med. 2005;15(6):442–7.
Khan K, Fuller P, Brukner P, et al. Outcome of conservative and surgical management of navicular stress fracture in athletes: 86 cases proven with computerized tomography. Am J Sports Med. 1992;20:657–66.
Khan K, Brukner P, Kearney C, et al. Tarsal navicular stress fracture in athletes. Sports Med. 1994;17:65–7.
Fowler JR, Gaughan JP, Boden BP, et al. The non-surgical and surgical treatment of tarsal navicular stress fractures. Sports Med. 2011;41(8):613–9.
Torg JS, Moyer J, Gaughan JP, et al. Management of tarsal navicular stress fractures: conservative versus surgical treatment: a meta-analysis. Am J Sports Med. 2010;38(5):1048–53.
Saxena A, Fullem B, Hannaford D. Results of treatment of 22 navicular stress fractures and a new proposed radiographic classification system. J Foot Ankle Surg. 2000;39(2):96–103.
Guermazi A, Hayashi D, Jarraya M. Sports injuries at the Rio de Janeiro 2016 summer Olympics: use of diagnostic imaging services. Radiology. 2018;287(3):922–32.
Iwamoto J, Takeda T. Stress fractures in athletes: review of 196 cases. J Orthop Sci. 2003;8(3):273–8.
Shelbourne KD, Fisher DA, Rettig AC, McCarroll JR. Stress fractures of the medial malleolus. Am J Sports Med. 1988;16:60–3.
Sherbondy PS, Sebastianelli WJ. Stress fractures of the medial malleolus and distal fibula. Clin Sports Med. 2006;25:129–37.
Kor A, Saltzman AT, Wempe PD. Medial malleolar stress fractures: literature review, diagnosis, and treatment. J Am Podiatr Med Assoc. 2003;93(4):292–7.
Shabat S, Sampson KB, Mann G, et al. Stress fractures of the medial malleolus: review of the literature and report of a 15-year-old elite gymnast. Foot Ankle Int. 2002;23(7):647–50.
Orava S, Karpakka J, Taimela S, et al. Stress fracture of the medial malleolus. J Bone Joint Surg Am. 1995;77(3):362–5.
D’Hooghe P, Wiegerinck JI, Tol JL, et al. 22 year old professional soccer player with atraumatic ankle pain. Br J Sports Med. 2015;49(24):1589–90.
Kerkhoffs GM, Versteegh VE, Sierevelt IN, Kloen P, van Dijk CN. Treatment of proximal metatarsal V fractures in athletes and non-athletes. Br J Sports Med. 2012;46(9):644–8.
McInnis KC, Ramey LD. High-risk stress fractures: diagnosis and management. PM R. 2016;8:S113–24.
Junge A, Rösch D, Peterson L, Graf-Baumann T, Dvorak J. Prevention of soccer injuries: a prospective intervention study in youth amateur players. Am J Sports Med. 2002;30(5):652–9.
Soligard T, Myklebust G, Steffen K, Holme I, Silvers H, Bizzini M, Junge A, Dvorak J, Bahr R, Andersen TE. Comprehensive warm-up programme to prevent injuries in young female footballers: cluster randomised controlled trial. BMJ. 2008;337:a2469.
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Vinagre, G., Cruz, F., D’Hooghe, P. (2023). Evaluation of Stress Fractures. In: Lane, J.G., Gobbi, A., Espregueira-Mendes, J., Kaleka, C.C., Adachi, N. (eds) The Art of the Musculoskeletal Physical Exam. Springer, Cham. https://doi.org/10.1007/978-3-031-24404-9_71
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