Abstract
Single-photon emission computed tomography (SPECT) imaging has evolved rapidly during the past decades since the introduction of the Anger camera in 1970, the posterior rotating gantry and dual detectors with better reconstruction processes, and quantitative data analysis. In the late 1990s, hybrid SPECT/CT imaging appeared to improve diagnostic accuracy with precise anatomical location and image quality with attenuation correction. In the last 10 years, all these equipment have had important improvements to allow us the characterization of the pathology based on morphologic pattern recognition, hand in hand with the evolution in radiopharmaceuticals, to evaluate more and better physiological processes [1]. Conventional analog technologies have advanced to multidetector devices with direct conversion digital detectors that improve efficiency, resolution and image quality, resulting in faster studies with lower doses and even the ability to image multiple radionuclides simultaneously. This includes the last generation cadmium-zinc-telluride (CZT) scanners, which bring more possibilities in research and clinical practice, especially in nuclear cardiology [2–4]. There is no denying that SPECT is still the go-to choice for most cardiologists.
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Keywords
Single-photon emission computed tomography (SPECT) imaging has evolved rapidly during the past decades since the introduction of the Anger camera in 1970, the posterior rotating gantry and dual detectors with better reconstruction processes, and quantitative data analysis. In the late 1990s, hybrid SPECT/CT imaging appeared to improve diagnostic accuracy with precise anatomical location and image quality with attenuation correction. In the last 10 years, the improvements in this equipment and the evolution in radiopharmaceuticals have allowed us to improve in the evaluation of physiological processes and in the characterization of pathologies based on morphological patterns [1]. Conventional analog technologies have advanced to multidetector devices with direct conversion digital detectors that improve efficiency, resolution and image quality, resulting in faster studies with lower doses and even the ability to image multiple radionuclides simultaneously. This includes the last generation cadmium-zinc-telluride (CZT) scanners, which bring more possibilities in research and clinical practice, especially in nuclear cardiology [2,3,4]. There is no denying that SPECT is still the go-to choice for most cardiologists.
There are multiple SPECT/CT applications, and in this chapter, we introduce most of them with demonstrative examples. In tumor pathology, its best-known applications are the evaluation of bone tumors, especially osteoblastic metastases, neuroendocrine tumors, and parathyroid adenomas [5, 6]. However, there are other multiple uses such as the evaluation of hepatocellular carcinoma, liver metastasis, neuroblastoma, paraganglioma, and thyroid cancer. In non-tumor bone pathology, it is indicated in trauma, degenerative disease, and infection, for example – also in the evaluation of benign thyroid pathology, gastrointestinal bleeding, lymphatic system pathology, and pulmonary physiology, among others [5, 7,8,9]. SPECT systems as well as radiopharmaceuticals are more available and probably cost-effective than PET, so they remain and will remain at the forefront.
1 Tumors
1.1 Hepatocellular Carcinoma
1.1.1 Case 1
A 51-year-old man with a diagnosis of hepatocellular carcinoma. Selected SPECT (top) and SPECT/CT (bottom) of the liver with 99mTc-MAA particles injected into a hepatic arterial catheter showed several focal areas of slightly to moderately increased activity in the right and left hepatic lobes corresponding to multicentric hepatoma. Only 50% of hepatomas can be imaged with FDG-PET, mainly because of the high levels of phosphatase that dephosphorylate FDG and allow it to diffuse out of cells (Fig. 1) [10].
1.2 Liver Metastases
1.2.1 Case 1
A 68-year-old female patient with liver metastasis from breast cancer. Selected SPECT (top) and SPECT/CT (bottom) of the liver with 99mTc-MAA into the hepatic arterial catheter showed markedly heterogeneous activity in the liver caused by known metastases. There was no extra hepatic activity (Fig. 2) [11].
1.2.2 Case 2
Selected SPECT (top) and SPECT/CT (bottom) of the upper abdomen with 99mTc-MAA particles into a hepatic arterial catheter showed curvilinear activity along the gastric wall, indicating the suboptimal position of the hepatic arterial catheter (Fig. 3) [12].
1.2.3 Case 3
A 57-year-old female patient with hepatic metastasis of breast cancer. Selected SPECT (top) and SPECT/CT (bottom) images of the liver with 90Y microspheres injected into a hepatic arterial catheter showed increased activity in the right and left hepatic lobes, corresponding to metastatic lesions (Fig. 4) [13].
1.3 Neuroendocrine Tumors
1.3.1 Case 1
A 51-year-old male patient with chest tightness and dyspnea. He had prior history of a pancreatic neuroendocrine tumor, so 111In-octreotide SPECT/CT was done. Images showed focal increased activity in a soft tissue mass at the pericardium, which was posteriorly confirmed to be a metastatic lesion (Fig. 5) [14].
1.3.2 Case 2
A 72-year-old male patient with a history of midgut carcinoid. He attended with right shoulder and abdominal pain. 111In-octreotide SPECT/CT was performed, finding focal increased activity in the right glenoid at a slerotic lesion and the right hepatic lobe at a large necrotic mass. Posterior biopsy confirmed the diagnosis of metastatic neuroendocrine tumor (Fig. 6) [15].
1.3.3 Case 3
A 71-year-old male patient with abdominal pain, diarrhea, and elevated chromogranin A. 111In-octreotide SPECT/CT was performed, finding marked increased activity in a large pancreatic tail mass, as well as diffuse, increased activity in the portal vein. Surgical resection confirmed the diagnosis of a pancreatic neuroendocrine tumor with portal vein invasion (Fig. 7) [16].
1.3.4 Case 4
A 62-year-old female patient with a history of midgut carcinoid. She presented with cough, dyspnea, and abdominal pain, so 111In-octreotide SPECT/CT was done. Images showed a large mass in the right adrenal gland without abnormal increased activity. Also, diffuse, increased activity was noted in a consolidation at the right upper lung. Posterior biopsy of both lesions confirmed a right adrenal carcinoma and a metastatic neuroendocrine tumor in the right upper lung (Fig. 8) [17].
1.3.5 Case 5
A 54-year-old female patient with a history of rectal carcinoid. She developed abdominal pain and elevated serum levels of chromogranin A were found. 111In-octreotide SPECT/CT was performed, finding multifocal increased uptake in the right hepatic lobe at several biopsy confirmed metastasis (Fig. 9) [18].
1.3.6 Case 6
A 74-year-old female patient with abdominal pain and diarrhea. 111In-octreotide SPECT/CT was done, finding focal increased activity in the pancreatic head. The surgical diagnosis was a pancreatic neuroendocrine tumor (Fig. 10) [21].
1.3.7 Case 7
A 67-year-old male patient with hypertension, abdominal pain, and palpitations. Elevated urinary catecholamines were found, so 123I-MIBG SPECT/CT was performed. Images showed focal increased uptake in a left adrenal mass which was confirmed as a pheochromocytoma (Fig. 11) [22].
1.3.8 Case 8
A 68-year-old female patient with a history of midgut carcinoid developed chest pain and dyspnea. Chest X-ray showed a newly developed lung nodulex nodule and she had elevated serum levels of chromogranin A, so 111In-octreotide SPECT/CT was done. Images showed focal increased uptake in the right upper lung nodule, which was confirmed to be a metastatic neuroendocrine tumor (Fig. 12) [25].
1.3.9 Case 9
A 64-year-old female patient with a neuroendocrine tumor in the pancreatic tail. Selected SPECT (top) and SPECT/CT (bottom) images of the upper abdomen with 111In-octreotide showed a focal area of slightly increased activity in the pancreatic tail. No other lesions were observed (Fig. 13) [27].
1.3.10 Case 10
A 41-year-old male patient with a history of carcinoid tumor, who attended for a regular check-up. 111In-octreotide SPECT/CT was done, finding focal increased activity in the middle to lower abdomen corresponding to mesenteric lymph node metastases, as well as in two metastatic lesions in the right hepatic lobe (Fig. 14) [30].
1.3.11 Case 11
A 39-year-old male patient with biopsy-proven lung carcinoid, who underwent 111In-octreotide SPECT/CT for staging. Images showed focal increased activity in the right hilum at the primary tumor, without definite uptake in post-obstructive atelectasis (Fig. 15) [32].
1.3.12 Case 12
A 51-year-old female patient with a biopsy confirmed diagnosis of transverse colon neuroendocrine tumor. 111In-octreotide SPECT/CT was performed for staging, finding only focal increased uptake in the primary lesion at the proximal transverse colon (Fig. 16) [33].
1.4 Neuroblastoma
1.4.1 Case 1
A 3-year-old girl with confirmed diagnosis of retroperitoneal neuroblastoma. 123I-MIBG SPECT/CT was performed for further evaluation. Images showed focal increased uptake in a retroperitoneal mass adjacent to the left psoas muscle, corresponding to the primary tumor. Neuroblastoma is a neural crest cell tumor arising from the sympathetic chain, commonly in the adrenal gland, and the mean age at the diagnosis was 2 years. Metastases may be found in 75% of these patients. Meta-iodobenzylguanidine (MIBG) is similar to norepinephrine and is taken up by chromaffin granules that are in neuroblastoma and pheochromocytoma (Fig. 17) [35].
1.5 Paraganglioma
1.5.1 Case 1
A 59-year-old male patient, who attended with hypertension and perspiration. Elevated levels of urinary catecholamines were found, so 123I-MIBG SPECT/CT was done for further evaluation. Images showed focal increased activity in a retroperitoneal mass at the aortocaval space, as well as in the left kidney superior pole. The surgical diagnosis confirmed a primary renal paraganglioma with retroperitoneal metastasis (Fig. 18).
1.5.2 Case 2
A 57-year-old female patient with a history of left adrenal paraganglioma, who attended for routine check-up. 123I-MIBG SPECT/CT was performed, showing heterogeneous activity in the liver, with a focal nodular increased uptake in segment 5 (V). Heterogeneous activity in the liver is physiologic and related to timing of the imaging and radiotracer metabolism and excretion through the biliary system. However, focal increased uptake is an abnormal finding, and in this case, it corresponded to a metastatic lesion. Also, an active metastasis was found in the T8 vertebral body (Fig. 19) [36].
1.6 Thyroid Cancer
1.6.1 Case 1
A 59-year-old male patient with a history of thyroid cancer, who underwent coronary CT, finding incidentally multiple lung nodules. 131I SPECT/CT showed moderately to intense increased iodine uptake in the nodules, confirming metastatic disease. Iodine therapy with 200 mCi of 131I was administered (Figs. 20, 21, 22 and 23) [37].
1.6.2 Case 2
A 34-year-old female patient with thyroid cancer, who underwent total thyroidectomy with central neck dissection. On 131I ablation scan, bone metastases were found, which were treated with 250 mCi of 131I. Post-treatment iodine scan and SPECT/CT were taken, showing intense focal iodine uptakes at T4 and T6, confirming iodine-avid bone metastases (Figs. 24, 25, 26, 27, 28, and 29) [38].
1.6.3 Case 3
A 62-year-old female patient with thyroid cancer history, who was treated with thyroidectomy 6 months earlier. She attended a routine follow-up without symptoms and normal serum levels of thyroglobulin. Selected SPECT (top) and SPECT/CT (bottom) with 131I demonstrated a focal area of moderately increased activity in the left thyroid bed, which was confirmed to be residual functioning thyroid tissue (Fig. 30).
1.7 Parathyroid Adenoma
1.7.1 Case 1
A 63-year-old male patient with hypercalcemia and weight loss. Laboratory tests showed abnormal serum calcium, phosphorus, and parathyroid hormone levels, so primary hyperparathyroidism was suspected. 99mTc-MIBI SPECT/CT was performed finding focal delayed uptake in the lower aspect of the right thyroid lobe, corresponding to a parathyroid adenoma, type E (Figs. 31, 32, 33, 34, and 35) [40, 41].
1.7.2 Case 2
A 63-year-old female patient with suspicion of parathyroid adenoma, who underwent 99mTc-MIBI SPECT/CT. Images showed a focal area of moderately increased activity in the right lower anterior mediastinum, which was confirmed as a parathyroid adenoma, type F (Fig. 36) [42].
1.7.3 Case 3
A 71-year-old female patient with primary hyperparathyroidism, who underwent 99mTc-MIBI SPECT/CT. Images showed a focal moderately increased activity in the right paraesophageal area at the level of the thoracic inlet, which corresponded to a parathyroid adenoma, type F (Fig. 37) [42].
1.7.4 Case 4
A 56-year-old male patient with confirmed diagnosis of a parathyroid adenoma (type E). Selected SPECT (top) and SPECT/CT (bottom) of the neck and chest with 99mTc-MIBI were performed. Images showed a focal moderately increased activity in the right paratracheal area at the level of the right inferior thyroid bed (Fig. 38) [42].
1.7.5 Case 5
A 63-year-old female patient with suspicion of a parathyroid adenoma (type C). Selected SPECT (top) and SPECT/CT images of the neck and chest with 99mTc-MIBI showed a focal moderately increased activity in the right paraesophageal area, confirming the diagnosis (Fig. 39) [42].
1.8 Mesothelioma
1.8.1 Case 1
A 69-year-old male patient with chest pain and dyspnea. The diagnosis of a mesothelioma was confirmed and 99mTc-MAA SPECT/CT was performed during staging. Images showed slightly decreased activity in the right upper and middle lobes as well as moderately decreased activity in the right lower lobe. Also noted were perfusion defects along the posterolateral periphery of the right lower lobe owing to nodular pleural lesions (Fig. 40) [43].
1.9 Bone Tumors
1.9.1 Case 1
A 10-year-old girl with a history of ossifying fibroma, who underwent 99mTc-methylene diphosphonate (MDP) SPECT/CT during a follow-up. Images showed moderately increased activity in the bilateral maxillary sinuses and right mandible at expansile bone lesions with fibrous matrix and peripheral sclerotic rim. Ossifying fibromas are benign bone tumors and occur often in children under 10 years in the tibia, femur, mandible, maxilla, and nasal areas (Fig. 41) [45].
1.9.2 Case 2
A 76-year-old male patient with lower back pain. 99mTc-MDP SPECT/CT showed focal increased uptake at bilateral L5-S1 facet joints, with degenerative changes. Additionally, a focal increased uptake was noted at the superior aspect of the left iliac bone, corresponding to a non-aggressive bone lesion with a central hipodense nidus surrounded by sclerotic bone changes, which was confirmed to be an osteoid osteoma (Fig. 42).
1.10 Bone Metastases
1.10.1 Case 1
A 38-year-old female patient with a history of breast cancer, who attended with right shoulder pain. 99mTc-MDP SPECT/CT was done, finding focal moderately increased activity in the right scapular body, caused by metastasis. Bone metastases are over ten times more common than primary bone tumors. Most metastases occur in the red bone marrow, most commonly in the axial skeleton. Osteoblastic metastases often occur with prostate cancer, transitional cell carcinoma, mucinous tumor, and carcinoid, whereas lytic metastases mostly occur with lung, thyroid, and renal cancers. Breast, stomach, and colon cancers can show osteolytic or osteoblastic lesions (Fig. 43) [46].
1.10.2 Case 2
A 65-year-old female patient with a history of breast cancer, who attended due to right knee pain without previous trauma. 99mTc-MDP SPECT/CT showed markedly increased activity in the lateral posterior condyle of the right distal femur at a mixed lytic and blastic bone lesion, consistent with bone metastasis (Fig. 44).
1.10.3 Case 3
A 47-year-old female patient with a history of breast cancer presented with pain in the lower back. Selected SPECT (top) and SPECT/CT (bottom) images of the pelvis with 99mTc-MDP showed markedly increased activity in the left sacral ala, abutting the sacroiliac joint (Fig. 45).
1.10.4 Case 4
A 66-year-old female patient with a history of non-Hodgkin lymphoma. She attended an early checkup due to lower back pain. 99mTc-MDP SPECT/CT was performed, finding focal areas of slightly increased activity in the bilateral iliac alae and tuberosities as well as L3-S1 vertebral bodies. Biopsy confirmed active lymphoma involvement (Fig. 46).
2 Non-Tumorous Conditions
2.1 Bone
2.1.1 Case 1
A 71-year-old female patient with chronic right knee pain. The clinical diagnosis was a medial meniscus tear in the right knee, and 99mTc-MDP SPECT/CT was done for further evaluation. Focal increased uptake was found in the right medial meniscus area, confirming the clinical diagnosis and associated changes in the subjacent bone (Figs. 47, 48, 49, and 50) [49].
2.1.2 Case 2
A 56-year-old female with a history of breast cancer complained of pain in her right lower posterior chest after a fall. 99mTc-MDP SPECT/CT showed focal increased activity in the right posterior 11th rib, corresponding to a callus formation at a fracture seen on CT. An acute fracture (up to 3–4 weeks after initial injury) will show increased radiotracer uptake surrounding the fracture site. Ninety-five percent of fractures are positive in patients under 65 years old, but skull fractures rarely show activity. In the healing phase with a variable time course, there is a gradual decrease in radiotracer activity, but 40% of fractures remain abnormal after 1 year (Fig. 51) [50].
2.1.3 Case 3
A 65-year-old male patient with a history of lung cancer, who developed a backache following a car accident. 99mTc-MDP SPECT/CT showed a focal area of markedly increased activity in the spinous process of L4, corresponding to a fracture shown on CT. Slightly increased activity in the bilateral facet joints of L4 was also noted, caused by degenerative changes (Fig. 52) [51].
2.1.4 Case 4
A 61-year-old female patient with chronic bilateral shoulder pain and limitation was admitted for evaluation. 99mTc-MDP SPECT/CT was performed, finding diffuse increased uptake in the bilateral shoulder joint capsules and bony structures, which was consistent with adhesive capsulitis, more severe in the right shoulder (Figs. 53, 54, 55, and 56) [53].
2.1.5 Case 5
A 21-year-old male patient with bilateral temporomandibular joint pain. 99mTc-MDP SPECT/CT was performed, finding increased uptake in both temporomandibular joints (right > left), due to degenerative osteoarthritis (Fig. 57).
2.1.6 Case 6
A 48-year-old male patient with right knee varus deformity treated with high tibial osteotomy. In the immediate postoperative period, 99mTc-MDP SPECT/CT was performed (top), finding, in addition to the normal changes of surgery, degenerative changes in the right knee with increased focal uptake in the femorotibial joint, more marked in the medial compartment, as well as in the patellofemoral joint. Three months after surgery, the patient attended with mild pain in the right knee. A new study was carried out (bottom) where degenerative changes showed improvement, but as a new finding, an increased uptake was observed in one of the surgical screws at the proximal tibia. Normal reactive postoperative changes were considered as the first option; however, a short-term follow-up was recommended to rule out other complications, which were later discarded (Fig. 58).
2.1.7 Case 7
A 16-year-old male patient with a history of leukemia, who developed left hip pain after completion of chemotherapy. 99mTc-MDP SPECT/CT showed a curvilinear moderately increased activity in the left femoral head at an ill-defined area of increased density on CT, caused by a healing microfracture with avascular necrosis (AVN). AVN is cellular death of bone components caused by interruption of the blood supply. It often leads to destruction of the joint articular surface. The classic sites are the head of the femur, the neck of the talus, and the waist of the scaphoid. AVN initially shows decreased radiotracer activity in the affected region, followed by a hyperemic phase with increased uptake (Fig. 59) [55].
2.1.8 Case 8
A 20-year-old male patient with progressive low back pain, worsened by physical activity. 99mTc-MDP SPECT/CT was performed and showed increased uptake in the inferior aspect of bilateral sacroiliac joints, without morphologic changes. The findings were consistent with sacroiliitis (Fig. 60).
2.1.9 Case 9
A 27-year-old male patient with right foot pain. 99mTc-MDP SPECT/CT was performed finding focal increased uptake in the medial aspect of the midfoot, adjacent to the medial side of the navicular bone, at an accessory ossicle. These findings confirmed the diagnosis of accessory navicular syndrome (Fig. 61).
2.2 Others
2.2.1 Gastrointestinal Bleeding
2.2.1.1 Case 1
A 10-year-old male patient with anaplastic large B-cell lymphoma was suffering from hematochezia caused by acute graft-versus-host disease (GVHD) after peripheral blood stem cell treatment. 99mTc-labeled red blood cell (99mTc-RBC) gastrointestinal bleeding SPECT/CT was done to find the bleeding source. A focal uptake was found in the third portion of the duodenum, corresponding to the acute bleeding site (Figs. 62, 63, 64, 65, 66, and 67) [56].
2.2.1.2 Case 2
A 68-year-old male patient with a history of cystectomy for bladder cancer. He developed pain in the right lower abdomen and also noticed bloody stool. 99mTc-RBC SPECT/CT demonstrated a curvilinear moderately increased activity in the ileal conduit as well as the pouch and bag indicating active bleeding. 99mTc-RBC is useful for detecting active gastrointestinal bleeding and is prepared in vitro by mixing 1–3 mL of anticoagulated blood with stannous chloride and an oxidizing agent. The labeling procedure takes at least 20 minutes. Bleeding rates as low as 0.2 mL/min can be detected with a tagged red blood cell study compared to 1 mL/min for angiography. 99mTc-sulfur colloid requires a significant preparation time and is useful only for acute active bleeding with 2–3 minutes of vascular half-time. A positive study shows an activity that changes shape and position over time due to the peristalsis of intraluminal blood (Fig. 68) [57].
2.2.2 Abscess
2.2.2.1 Case 1
A 78-year-old female patient with a history of multiple myeloma, who attended for backache and fever. 111In-WBC SPECT/CT showed a focal area of markedly increased activity in the left semispinalis muscle at the posterior lower neck adjacent to the spinous process of C6, corresponding to an ill-defined inflammatory collection. 111In leukocyte, scan is helpful for detecting acute infection or inflammation. Its advantages compared to 99mTc-D, L-hexamethyl propyleneamine oxime (HMPAO) scan include the absence of interfering bowel and renal activity and the ability to perform delayed 24-hour imaging as well as simultaneous 99mTc-sulfur colloid or MDP scan. 67Ga citrate scan is useful for detecting chronic infection or inflammation with lymphocytes or macrophages (Fig. 69) [58].
2.2.3 Benign Thyroid Pathology
2.2.3.1 Case 1
A 57-year-old female patient with a new diagnosis of hypothyroidism.131I SPECT/CT showed a focal area of moderately increased activity in the midline of the tongue base, corresponding to ectopic thyroid tissue in the thyroglossal duct. Ectopic thyroid refers to the presence of thyroid tissue in locations other than the normal anterior neck between the second and fourth tracheal cartilages. Lingual thyroid is the most common type (Fig. 70) [59].
2.2.3.2 Case 2
A 32-year-old female patient with neck pain and fever. Thyroid function studies showed low TSH with increased T3 and T4, so subacute thyroiditis was suspected. 99mTc-pertechnetate thyroid scan SPECT/CT was performed showing faintly visualized thyroid activity and decreased percentage of thyroid uptake (0.08%), so the diagnosis was confirmed (Fig. 71).
2.2.3.3 Case 3
A 37-year-old female patient with known hyperthyroidism, Graves’ disease, who attended her annual checkup. Thyroid function studies showed low TSH with increased T3 and T4, and increased TSH-R-Ab. 99mTc-pertechnetate thyroid scan SPECT/CT was performed showing diffuse enlargement of the thyroid gland with markedly increased percentage of thyroid uptake (26.32%) (Fig. 72).
2.2.4 Salivary Glands
2.2.4.1 Case 1
A 63-year-old female patient with nonspecific sicca. 99mTc-pertechnetate salivary gland scan SPECT/CT with quantitative analysis was performed and showed mild decreased uptake in bilateral parotid glands, with normal submandibular glands uptake, and normal bilateral function (Figs. 73 and 74).
2.2.5 Cerebrospinal Fluid (CSF)
2.2.5.1 Case 1
A 66-year-old male patient with a history of head trauma. Moderate enlargement of ventricular size was found on CT, so after ventricular derivation, selected SPECT (top) and SPECT/CT (bottom) images of the head at 24 hours after injection of 111In-DTPA into the L3-L4 spinal canal were obtained for evaluation. Images showed distribution in basal and Sylvian cisterns, without significant residual hydrocephalus or activity in the lateral ventricle, indicating non-communicating hydrocephalus (Fig. 75) [60].
2.2.5.2 Case 2
A 72-year-old male patient with progressive gait disturbance, urinary incontinence, and dementia symptoms. Selected SPECT (top) and SPECT/CT (bottom) images of the head at 24 hours after injection of 111In-DTPA into the L3-L4 spinal canal showed moderately increased activity in the lateral ventricles but no significant activity had migrated over to the convexity beyond the Sylvian cistern, indicating normal pressure hydrocephalus (Fig. 76).
2.2.6 Central Venous Line Obstruction
2.2.6.1 Case 1
A 46-year-old male with a left central venous line complained of pain in the substernal area. A nuclear dynamic venous flow study using 99mTc-DTPA showed a focal area of increased activity in the distal left innominate vein, representing obstruction. Venous obstruction occurs when blood clots or vascular tissues develop and narrow the channel for flow. More than 40% of patients with a central venous line can develop a venous obstruction, and they may experience a swollen arm, neck pain, facial swelling, or shortness of breath (Fig. 77) [61].
2.2.7 Renal
2.2.7.1 Case 1
A 49-year-old male patient with right hydronephrosis due to renal pelvis stones. 99mTc-DTPA and SPECT/CT were performed for evaluation, finding decreased uptake in the right kidney with no significant effect in renal function. Calculated GFR (ml/min): left 48.58, right 42.36 (Fig. 78).
2.2.7.2 Case 2
A 72-year-old male patient with history of kidney transplant in 2015, who attended his annual checkup. 99mTc-DTPA and SPECT/CT were performed to find a normal functioning transplanted kidney with calculated GFR (ml/min) of 96.78. Native non-functioning kidneys showed atrophy in the right side and a large water bag kidney in the left side (Fig. 79).
2.2.8 Lymphatic System
2.2.8.1 Case 1
A 44-year-old woman with a history of right breast cancer treated with total mastectomy and axillary lymph node dissection, who developed right arm lymphedema. 99mTc-ASC lymphoscintigraphy and SPECT/CT was performed and showed absence of main lymphatics in the right arm, as well as absence of lymph nodes and positive dermal backflow (DBF) until the elbow level. In the left arm, normal lymphatic vessels and lymph nodes were observed (Fig. 80).
2.2.8.2 Case 2
A 45-year-old male patient with confirmed diagnosis of left preauricular melanoma. Selected SPECT (top) and SPECT/CT (bottom) images of the neck, including the lower head, after intradermal injection of 99mTc filtered sulfur colloidal particles around the tumor, demonstrated focal areas of slightly increased activity in the left upper jugular lymphatic chain (level IIB), indicating sentinel lymph nodes. The sentinel lymph node is hypothetically the first lymph node or group of nodes to drain the cancer. It is postulated that sentinel lymph nodes are the target organs primarily reached by metastasizing cancer cells from the tumor. The spread of some forms of cancer usually follows an orderly progression (Fig. 81) [62].
2.2.8.3 Case 3
A 59-year-old female patient with uterine cervical cancer. SPECT (top) and SPECT/CT (bottom) images of the pelvis after subcutaneous injection of 99mTc-filtered sulfur colloid particles around the area were performed. Images showed moderate increased activity in the left external iliac lymph node and slightly increased activity in the left inguinal superficial lymph node, indicating sentinel lymph nodes (Fig. 82).
2.2.8.4 Case 4
A 53-year-old female patient with recent diagnosis of melanoma in the right anterior chest wall. Selected SPECT (top) and SPECT/CT (bottom) images of the chest after intradermal injection of 99mTc-filtered sulfur colloid showed a focal area of slightly increased activity in the right superficial axillary lymph node (level I), indicating a sentinel lymph node (Fig. 83).
2.2.8.5 Case 5
A 64-year-old male patient with a squamous cell carcinoma in the right tongue base. Selected SPECT (top) and SPECT/CT (bottom) images of the neck, including the lower head, after subcutaneous injection of 99mTc Lymphoseek showed a focal area of slightly increased activity in the right carotid space, indicating a sentinel lymph node. Lymphoseek is a radioactive diagnostic agent for lymphatic mapping and guiding sentinel lymph node biopsy (Fig. 84) [63].
2.2.9 Lung (V/Q)
2.2.9.1 Case 1
A 58-year-old male patient with non–small cell lung cancer, adenocarcinoma. 99mTc-MAA SPECT/CT was performed, finding a non-uniform distribution of the particles, indicating moderately decreased perfusion in the right upper, middle, and lower lobes. There was complete absence of particles within the tumor. 99mTc-MAA SPECT/CT is frequently performed for the presurgical evaluation of patients with lung cancer to determine the extent of surgery (Figs. 85, 86, and 87) [64, 65].
2.2.9.2 Case 2
A 26-year-old female patient with a history of recurrent respiratory papillomatosis, who developed a lung squamous cell carcinoma. Presurgical lung perfusion scan with SPECT/CT was performed to determine lung function and extent of surgery. Images showed a spiculated dense nodule in the right lower lobe, corresponding to the primary tumor, as well as complete perfusion defect in the whole lobe, probably due to obstruction (Fig. 88).
2.2.10 Accessory Spleen
2.2.10.1 Case 1
A 50-year-old male patient attended a routine checkup and abdominal CT was performed finding an enhancing mass adjacent to the pancreatic tail. 99mTc-denatured RBC spleen scan was done for differential diagnosis, finding focal increased uptake in the nodular lesion at the pancreatic tail, which corresponded to an accessory spleen (Figs. 89, 90, 91, and 92) [66].
2.2.11 Adrenal Hyperplasia
2.2.11.1 Case 1
A 52-year-old male patient with right flank pain and abnormal adrenal function tests. So 123I-MIBG SPECT/CT was performed for further evaluation. Images showed moderately increased activity in both adrenal glands, corresponding to adrenal hyperplasia. Also, a right renal mass was observed on CT, which was later confirmed to be a renal cell carcinoma (Fig. 93).
2.2.12 Heart
2.2.12.1 Case 1
An 84-year-old male patient with a history of asymptomatic coronary atherosclerosis, who attended a routine checkup and referred occasional chest pain. Laboratory studies were carried out finding increased troponin and proBNP, as well as increased free light chain of lambda and kappa (18.66 and 21.16, respectively). 99mTc-HMDP heart planar scan with SPECT/CT was performed and images showed significant heart uptake, which suggested transthyretin-related (TTR) amyloidosis, later confirmed with biopsy (Fig. 94) [67].
2.2.13 Brain
2.2.13.1 Case 1
A 35-year-old asymptomatic man with diagnosis of Moyamoya disease who attended a periodic checkup. 99mTc-HMPAO brain perfusion SPECT was performed. Basal study showed adequate perfusion in all vascular territories bilaterally. In post-acetazolamide study, perfusion is maintained and/or increased, which indicates that the vascular reserve is preserved. Anterior cerebral artery (ACA), middle cerebral artery (MCA), internal carotid artery (ICA = ACA + MCA), and posterior cerebral artery (PCA) (Fig. 95) [68].
2.2.13.2 Case 2
An 84-year-old woman with a diagnosis of severe atherosclerotic carotid stenosis of both extracranial internal carotid arteries. 99mTc-HMPAO brain perfusion SPECT was performed to determine if there was surgical indication. Basal study showed adequate perfusion in all territories. However, the post-acetazolamide study showed decreased perfusion in the left ICA (ACA + MCA) territory, indicating that the vascular reserve is compromised because the stenosis has progressed to the point of consuming compensatory capacity. These findings indicate that the patient would benefit from surgical intervention to prevent and/or reduce the risk of stroke (Fig. 96) [68].
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The authors gratefully acknowledge Dr. Dong Soo Lee and Dr. Keon Wook Kang for their contributions to this chapter as it appeared in the previous edition.
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Kim, E.E., Murad, V., Paeng, JC., Im, HJ., Kim, JY., Cheon, GJ. (2022). Atlas and Anatomy of SPECT/CT. In: Kim, E.E., Murad, V., Paeng, JC., Cheon, GJ. (eds) Atlas and Anatomy of PET/MRI, PET/CT and SPECT/CT. Springer, Cham. https://doi.org/10.1007/978-3-030-92349-5_3
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