Abstract
It is well established that changes in bone blood and interstitial fluid flows are associated with changes in the bone remodeling process. These flows in bone are a result not only of trans-cortical pressure gradients produced by vascular and hydro-static pressure, but also of mechanical loadings. Mechanical load-induced intraosseous pressure gradients may result in some fluid stimuli effects which, in turn, may enable bone cells to detect external mechanical signals. In this paper, the exploitation of a 2D continuum model based on classical poroelasticity is presented within a variational framework. The investigation is aimed at describing how mechanical actions can affect the remodeling process of a bone tissue. The focus is on the introduction of a physically motivated strain energy contribution aimed to take into account the presence of saturating fluid in the interconnected pores of bone tissue. The interaction with a bio-resorbable organic ceramic material like those used in bone graft implants is also considered in presented model. Numerical results are provided in a relevant exemplary case.
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Barchiesi, E., Giorgio, I., Alzahrani, F., Hayat, T. (2019). The Effect of Mechanical Load-induced Intraosseous Pressure Gradients on Bone Remodeling. In: Abali, B., Altenbach, H., dell'Isola, F., Eremeyev, V., Öchsner, A. (eds) New Achievements in Continuum Mechanics and Thermodynamics. Advanced Structured Materials, vol 108. Springer, Cham. https://doi.org/10.1007/978-3-030-13307-8_3
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