Abstract
There is a well-established literature in the field of hypertension documenting an association between higher dietary salt intake and elevated blood pressure. As long ago as 1904, Ambard and Beajard published a report showing that some hypertensive patients demonstrate a substantial reduction in blood pressure when they restrict their salt intake (cited in Tobian & Hanlon, 1990). Since then, numerous additional clinical investigations have documented beneficial lowering of elevated pressure in many hypertensive patients. Additionally, crosscultural comparisons have highlighted the fact that societies where the average daily salt intake is less than half of that consumed in the United States demonstrate a parallel reduction in the incidence of hypertension while societies consuming more salt show an even higher incidence. Furthermore, “salt-sensitive” and “salt-resistant” animal models have been developed and studied in which the direct causal role of high salt intake in the pathogenesis of hypertension and related cardiovascular morbidity and mortality has been verified. (For reviews, see MacGregor, 1983; Meneely & Battarbee, 1976; Meneely & Dahl, 1961).
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References
Ambrosioni, E., Costa, F. V., Borghi, C., Montebugnoli, L., Giordani, M. F., & Magnani, B. (1982). Effects of moderate salt restriction on intralymphocytic sodium and pressor response to stress in borderline hypertension. Hypertension, 4, 789–794.
Anderson, D. E. (1986). Operant conditioning, sodium loading, and experimental hypertension. Journal of Cardiovascular Pharmacology, 8(5), S23–S30.
Anderson, D. E., Kearns, W. D., & Better, W. E. (1983a). Progressive hypertension in dogs by avoidance conditioning and saline infusion. Hypertension, 5, 286–291.
Anderson, D. E., Kearns, W. D., & Worden, T. J. (1983b). Potassium infusion attenuates avoidancesaline hypertension in dogs. Hypertension, 5, 415–420.
Anderson, D. E., Gomez-Sanchez, C., & Dietz, J. R. (1986). Suppression of plasma renin and aldosterone in stress-salt hypertension in dogs. American Journal of Physiology, 251, R181–R186.
Anderson, D. E., Dietz, J. R., & Murphy, P. (1987). Behavioral hypertension in sodium-loaded dogs is accompanied by sustained sodium retention. Journal of Hypertension, 5, 99–105.
Bolli, P., Amann, F. W., Hulthen, L., Kiowski, W., & Buhler, F. R. (1981). Elevated plasma adrenaline reflects sympathetic overactivity and enhanced alpha-adrenoceptor-mediated vasoconstriction in essential hypertension. Clinical Science, 61, 161s–164s.
Borghi, C., Costa, F. V., Boschi, S., Mussi, A., & Ambrosioni, E. (1986). Predictors of stable hypertension in young borderline subjects: A five-year follow-up study. Journal of Cardiovascular Pharmacology, 8(5), S138–S141.
Cottier, C., Perini, Ch., & Rauchfleish, U. (1987). Personality traits and hypertension: An overview. In S. Julius & D. R. Bassett (Eds.), Handbook of hypertension, Vol 9: Behavioral factors in hypertension (pp. 123–140). New York: Elsevier.
Denton, D. (1976). Hypertension: A malady of civilization? In M. P. Sambhi (Ed.), Systemic effects of antihypertensive drugs (pp. 559–583). New York: Stratton Intercontinental.
DiBona, G. F., & Jones, S. Y. (1991). Renal manifestations of NaCl sensitivity in borderline hypertensive rats. Hypertension, 17, 44–53.
Dimsdale, J. E., Graham, R., Ziegler, M. G., Zusman, R., & Berry, C. C. (1987). Age, race, diagnosis, and sodium effects on the pressor response to infused norepinephrine. Hypertension, 10, 564–569.
Dimsdale, J. E., Ziegler, M. G., Mills, P., Delehanty, S. G., & Berry, C. C. (1990a). Effects of salt, race, and hypertension on reactivity to Stressors. Hypertension, 16, 573–580.
Dimsdale, J. E., Ziegler, M. G., Mills, P., & Berry, C. C. (1990b). Prediction of salt sensitivity. American Journal of Hypertension, 3, 429–435.
Falkner, B. (1990). Differences in blacks and whites with essential hypertension: Biochemistry and endocrine. Hypertension, 15, 681–686.
Falkner, B., & Kushner, H. (1990). Effect of chronic sodium loading on cardiovascular response in young blacks and whites. Hypertension, 15, 36–43.
Falkner, B., Onesti, G., & Angelakos, E. T. (1981). Effect of salt loading on the cardiovascular response to stress in adolescents. Hypertension, 3(II), II195–II199.
Fujita, J., Ando, K., & Ogata, E. (1990). Systemic and regional hemodynamics in patients with salt-sensitive hypertension. Hypertension, 16, 235–244.
Grignolo, A., Koepke, J. P., & Obrist, P. A. (1982). Renal function, heart rate, and blood pressure during exercise and avoidance in dogs. American Journal of Physiology, 242, R482–R490.
Grim, C. E., Luft, F. C., Miller, J. Z., Meneely, G. R., Battarbee, H. D., Hames, C. G., & Dahl, L. K. (1980). Racial differences in blood pressure in Evans County, Georgia: Relationship to sodium and potassium intake and plasma renin activity. Journal of Chronic Diseases, 33, 87–94.
Gutmann, M. C., & Benson, H. (1971). Interaction of environmental factors and systemic arterial blood pressure: A review. Medicine, 50, 543–553.
Guyton, A. C. (1989). Dominant role of the kidneys and accessory role of whole-body autoregulation in the pathogenesis of hypertension. American Journal of Hypertension, 2, 575–585.
Harshfield, G. A., Pulliam, D. A., & Alpert, B. S. (in press). Patterns of sodium excretion during sympathetic nervous system arousal. Hypertension, 17.
Henry, J. P., & Cassel, J. C. (1969). Psychosocial factors in essential hypertension. Recent epidemiological and animal experimental evidence. American Journal of Epidemiology, 90, 171–200.
Hollenberg, N. K., & Williams, G. H. (1989). Sodium-sensitive hypertension: Implications of pathogenesis for therapy. American Journal of Hypertension, 2, 809–815.
Julius, S. (1987). Hemodynamic, pharmacologic and epidemiologic evidence for behavioral factors in human hypertension. In S. Julius & D. R. Bassett (Eds.), Handbook of hypertension, Vol 9: Behavioral factors in hypertension (pp. 59–74). New York: Elsevier.
Khaw, K. T., & Barrett-Connor, E. (1987). Dietary potassium and stroke-associated mortality. New England Journal of Medicine, 316, 235–240.
Kimura, G., Ashida, T., Abe, H., Kawano, Y., Yoshimi, H., Sanai, T., Imanishi, M., Yoshida, K., Kawamura, M., Kojima, S., Kuramochi, M., & Omae, T. (1990). Sodium sensitive and sodium retaining hypertension. American Journal of Hypertension, 3, 854–858.
Koepke, J. P., & DiBona, G. F. (1985a). Central beta-adrenergic receptors mediate renal nerve activity during stress in conscious spontaneously hypertensive rats. Hypertension, 7, 350–356.
Koepke, J. P., & DiBona, G. F. (1985b). High sodium intake enhances renal nerve and antinatriuretic responses to stress in spontaneously hypertensive rats. Hypertension, 7, 357–363.
Koepke, J. P., & DiBona, G. F. (1986). Central adrenergic receptor control of renal function in conscious hypertensive rats. Hypertension, 8, 133–141.
Koepke, J. P., Grignolo, A., Light, K. C., & Obrist, P. A. (1983a). Central beta-adrenoceptor mediation of the antinatriuretic response to behavioral stress in conscious dogs. Journal of Pharmacological and Experimental Therapeutics, 227, 73–77.
Koepke, J. P., Light, K. C., & Obrist, P. A. (1985). Neural control of renal excretory function during behavioral stress in conscious dogs. American Journal of Physiology, 245, R251–R258.
Koepke, J. P., Jones, S. Y., & DiBona, G. F. (1987). Alpha-2 adrenoceptors in amygdala control renal sympathetic nerve activity and renal function in conscious spontaneously hypertensive rats. Brain Research, 404, 80–88.
Koepke, J. P., Jones, S. Y., & DiBona, G. F. (1988). Sodium responsiveness of central alphaadrenergic receptors in spontaneously hypertensive rats. Hypertension, 11, 326–333.
Krishna, C. G., Miller, E., & Kapoor, D. (1989). Increased blood pressure during potassium depletion in normotensive men. New England Journal of Medicine, 320, 1177–1182.
Lawler, J. E., Barker, G. F., Hubbard, J. W., & Schaub, R. G. (1981). Effect of stress on blood pressure and cardiac pathology in rats with borderline hypertension. Hypertension, 3, 496–505.
Lawton, W. J., Sinkey, C. A., Fitz, A. E., & Mark, A. L. (1988). Dietary salt produces abnormal renal vasoconstrictor responses to upright posture in borderline hypertensive subjects. Hypertension, 11, 529–536.
Light, K. C., & Turner, J. R. (in press). Stress-induced changes in the rate of sodium excretion in healthy black and white men. Journal of Psychosomatic Research.
Light, K. C., Koepke, J. P., Obrist, P. A., & Willis, P. W., IV (1983). Psychological stress induces sodium and fluid retention in men at risk for hypertension. Science, 220, 429–431.
Light, K. C., Turner, J. R., & Sherwood, A. (unpublished observations). Available upon request from K. C. Light.
Light, K. C., Wagner, P. G., & Willis, P. W., IV (unpublished manuscript). Effects of propranolol on renal excretion of sodium and fluid during rest and stress. Available upon request from K. C. Light.
Luft, F. C., Grim, C. E., Fineberg, N., & Weinberger, M. H. (1979). Effects of volume expansion and contraction in normotensive whites, blacks, and subjects of different ages. Circulation, 59, 643–650.
MacGregor, G. A. (1983). Sodium and potassium intake and blood pressure. Hypertension, 5,(111), III79–III84.
Meneely, G. R., & Battarbee, H. D. (1976). High sodium-low potassium environment and hypertension. American Journal of Cardiology, 38, 768–785.
Meneely, G. R., & Dahl, L. K. (1961). Electrolytes in hypertension: The effects of sodium chloride. Medical Clinics of North America, 45, 271–283.
Parfrey, P. S., Wright, P., & Ledingham, J. M. (1981a). Prolonged isometric exercise. Part 1: Effect on circulation and on renal excretion of sodium and potassium in mild essential hypertension. Hypertension, 3, 182–187.
Parfrey, P. S., Wright, P., & Ledingham, J. M. (1981b). Prolonged isometric exercise. Part 2: Effect on circulation and on renal excretion of sodium and potassium in young males genetically predisposed to hypertension. Hypertension, 3, 188–199.
Sanders, B. J., Cox, R. H., & Lawler, J. E. (1988). Cardiovascular and renal responses to stress in borderline hypertensive rat. American Journal of Physiology, 255, R431–R438.
Sowers, J. R., Zemel, M. B., Zemel, P., Beck, F. W. J., Walsh, M. F., & Zawada, E. T. (1988). Salt sensitivity in blacks: Salt intake and natriuretic substances. Hypertension, 12, 485–490.
Sullivan, J. M. (1986). Borderline hypertension and salt sensitivity. Journal of Cardiovascular Pharmacology, 8(5), S31–S35.
Tobian, L., & Hanlon, S. (1990). High sodium chloride diets injure arteries and raise mortality without changing blood pressure. Hypertension, 25, 900–903.
Tobian, L., Lange, J., Ulm, K., Wold, L., & Iwai, J. (1985). Potassium reduces cerebral hemorrhage and death rate in hypertensive rats, even when blood pressure is not lowered. Hypertension, 7(1), I110–I114.
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Light, K.C. (1992). Differential Responses to Salt Intake-Stress Interactions. In: Turner, J.R., Sherwood, A., Light, K.C. (eds) Individual Differences in Cardiovascular Response to Stress. Perspectives on Individual Differences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0697-7_13
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DOI: https://doi.org/10.1007/978-1-4899-0697-7_13
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