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Formation and Assembly of Alphavirus Glycoproteins

  • Chapter
The Togaviridae and Flaviviridae

Part of the book series: The Viruses ((VIRS))

Abstract

Among the variety of enveloped viruses that exist in nature, the Togaviridae family is generally considered to be among the simplest with regard to structure and composition of the virus. The virion structure is examined in detail in Chapter 22. In this chapter, we focus on the major protein components of the virion envelope and describe modifications of these proteins that occur as they mature from nascent polypeptides to fully mature and functional glycoproteins that form the spikes of the infectious particle. Most of our information about togavirus glycoproteins comes from biochemical studies of the two alphaviruses, Semliki Forest virus and Sindbis virus (Garoff et al., 1982). These viruses have provided valuable models for the analysis of membrane proteins.

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  1. Department of Microbiology and Immunology, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Milton J. Schlesinger & Sondra Schlesinger

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© 1986 Plenum Press, New York

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Schlesinger, M.J., Schlesinger, S. (1986). Formation and Assembly of Alphavirus Glycoproteins. In: Schlesinger, S., Schlesinger, M.J. (eds) The Togaviridae and Flaviviridae. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0785-4_5

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  • DOI: https://doi.org/10.1007/978-1-4757-0785-4_5

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