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Animal Models: Promises and Problems

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Animal Models of Depression

Abstract

The promise that a model of a mental illness holds for us is that once the model has been developed it should be relatively easy to not only determine the etiology of the illness but to effect a cure. The problem is that it is not easy to develop a true model of a mental illness. It could be that animal models are not possible because mental illnesses may be uniquely human disorders.

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Further Readings

  • Bain G (1980): The effects of norepinephrine perfusion of the mesencephalic reticular formation on behavior in the rat: interaction with several neuroleptic drugs on a measure of sustained attention. Ph.D. Dissertation, Boston University

    Google Scholar 

  • Baldessarini RJ and Fischer JE (1975): Biological models in the study of false neurochemical synaptic transmitters. In: Model Systems in Biological Psychiatry, Ingle DJ, Shein HM, eds. Cambridge, MA, MIT Press

    Google Scholar 

  • Beckett HD (1974): Hypotheses concerning the etiology of heroin addiction. In: Addiction, Bourne PG, ed. New York, Academic Press

    Google Scholar 

  • Cairncross KD, (1978): A new model for the detection of anti-depressant drugs: olfactory bulbectomy in the rat compared with existing models J Pharmacol Methods, 1:131–143

    Article  CAS  Google Scholar 

  • Cornfeldt M, Fisher B, Fielding S (1982): Rat internal capsule lesions: a new test for detecting antidepressants. Fed Proc 41:1066

    Google Scholar 

  • Costa E, Garattini S, Valzelli L (1960): Interaction between reserpine, chlorpromazine and imipramine. Experientia 16:461–463

    Article  PubMed  CAS  Google Scholar 

  • Dole VP and Nyswander ME (1967): Addiction—a metabolic disease. Arch Intern Med 120:19–24

    Article  PubMed  CAS  Google Scholar 

  • Eliasson M and Kornetsky C (1972): Interaction effects of chlorpromazine and reticular stimulation on visual attention behavior in rats. Psychonomic Science 26:261–262

    Google Scholar 

  • Esposito R and Kornetsky C (1977): Morphine lowering of self-stimulation thresholds: lack of tolerance with long-term administration. Science 195:189–191

    Article  PubMed  CAS  Google Scholar 

  • Estes WK and Skinner BF (1941): Some quantitative properties of anxiety. J Exper Psychol 29:390–400

    Article  Google Scholar 

  • Ferster CB (1973): A functional analysis of depression. Am Psychol 28:857–870

    Article  PubMed  CAS  Google Scholar 

  • Fibiger HC and Phillips AG (1981): Increased intracranial self-stimulation in rats after long-term administration of desipramine. Science 214:683–685

    Article  PubMed  CAS  Google Scholar 

  • Horowitz ZP, Ragozzino PW, and Leaf RC (1965): Selective block of rat mouse-killing by anti-depressants. Life Sci 4:1901–1912

    Google Scholar 

  • Hubner CB and Koob GF (1987): Ventral pallidal lesions produce decreases in cocaine and heroin self-administration in the rat. Society for Neuroscience Abstract 13(3):1717

    Google Scholar 

  • Hull C (1943): Principles of Behavior. New York: Appleton-Century

    Google Scholar 

  • Khantzian EJ (1980): An ego-self theory of substance dependence. In: Theories of Addiction, Lettieri DJ, Sayers M, Wallenstein HW, eds. NIDA Monograph 30, Rockville, Maryland, National Institute on Drug Abuse

    Google Scholar 

  • Kornetsky C (1977): Animal models: promises and problems. In: Animal Models in Psychiatry and Neurology, Hanin I, Usdin E, eds. New York: Pergamon Press

    Google Scholar 

  • Kornetsky C and Eliasson M (1969): Reticular stimulation and chlorpromazine: an animal model for schizophrenic overarousal. Science 165:1273–1274

    Article  PubMed  CAS  Google Scholar 

  • Kornetsky C and Markowitz R (1975): Animal models and schizophrenia. In: Model Systems in Biological Psychiatry, Ingle I, Shein HM, eds. Cambridge, MA: MIT Press

    Google Scholar 

  • Leith NJ and Barrett RJ (1976): Amphetamine and the reward system: evidence for tolerance and post drug depression. Psychopharmacology 46:19–25

    Article  CAS  Google Scholar 

  • Liebman JM (1983): Discrimination between reward and performance: A critical review of intracranial self-stimulation methodology. Neurosci Biobehav Rev 7:45–72

    Article  PubMed  CAS  Google Scholar 

  • Nuechterlein KH and Dawson ME (1984): Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophr Bulletin 10:160–203

    CAS  Google Scholar 

  • Payton M and Kornetsky C (1983): Brain-stimulation reward: thresholds versus response rates from various brain loci. Society for Neuroscience Abstract 9(2):977

    Google Scholar 

  • Seligman MEP and Beagley G (1975): Learned helplessness in the rat. J Comp Physiol Psychol 88:534–541

    Article  PubMed  CAS  Google Scholar 

  • Skinner BF (1948): “Superstition” in the pigeon. J Exper Psychol 83:658–666

    Google Scholar 

  • Stein J and Urdang L (1967): The Random House Dictionary of the English Language. New York: Random House

    Google Scholar 

  • Stein L (1962): New methods for evaluating stimulants and anti-depressants. In: Psychosomatic Medicine: The First Hahnemenn Symposium, Nodine JH, Moyer JH eds. Philadelphia: Lea and Fibiger

    Google Scholar 

  • Szewczak MR, Fielding S, Cornfeldt M (1982): Rat internal capsule lesion: further characterization of antidepressant screening potential. Society for Neuroscience Abstracts 8:465

    Google Scholar 

  • Watson JB (1914): Behavior: An Abstract to Comparative Psychology, Henry Holt, New York. As reviewed in R.S. Woodworm (1948): Contemporary Schools of Psychology, New York: Ronald Press

    Google Scholar 

  • Wauquier A (1976): The influence of psychoactive drugs on brain self-stimulation in rats: a review. In: Brain-stimulation Reward, Wauquier A, Rolls ET, eds. Amsterdam: North-Holland Publishing Company

    Google Scholar 

  • Wilner P (1984): The validity of animal models of depression. Psychopharmacology 83:1–16

    Article  Google Scholar 

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© 1989 Birkhäuser Boston

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Kornetsky, C. (1989). Animal Models: Promises and Problems. In: Koob, G.F., Ehlers, C.L., Kupfer, D.J. (eds) Animal Models of Depression. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6762-8_2

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  • DOI: https://doi.org/10.1007/978-1-4684-6762-8_2

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-6764-2

  • Online ISBN: 978-1-4684-6762-8

  • eBook Packages: Springer Book Archive

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