Abstract
In recent years evidence has accumulated suggesting that insulin-like growth factors may have significant autocrine or paracrine roles in regulating the rate of growth or state of differentiation of various types of normal and tumorous tissue (1,2). A paracrine/autocrine role for insulin-like growth factor-l (IGF-I) in embryonic development has been suggested by the following observations. IGF-I is secreted by cultured fetal cells and explants and binds to specific receptors in fetal tissue (3,4). IGF-I immunoreactivity is low in fetal serum (5) but both IGF-I immunoreactivity and mRNA are detected in fetal tissues during the course of gestation (6-11). The presence of the type-l IGF receptor during embryogenesis has been demonstrated by binding studies (12,13) and by detection of receptor mRNA (11,14).
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© 1991 Plenum Press, New York
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Bondy, C., Chin, E. (1991). IGF-I mRNA Localization in Trigeminal and Sympathetic Nerve Target Zones During Rat Embryonic Development. In: Raizada, M.K., LeRoith, D. (eds) Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Advances in Experimental Medicine and Biology, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5949-4_38
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DOI: https://doi.org/10.1007/978-1-4684-5949-4_38
Publisher Name: Springer, Boston, MA
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