Abstract
Model systems have been developed to study bronchogenic carcinoma in laboratory animals in order to better understand the pathogenesis and etiology of this disease in humans (1). By extrapolating the characteristics of experimental models for respiratory carcinogenesis, some risk factors for human lung cancer may ultimately be elucidated.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Nettesheim, P., and R.A. Griesemer. 1978. Experimental models for studies of respiratory tract carcinogenesis. In: Pathogenesis and Therapy of Lung Cancer. C.C. Harris, ed. Marcel Dekker: New York. pp. 75–188.
Doll, R. 1978. An epidemiologic perspective of the biology of cancer. Cancer Rea. 38: 3573–3583.
Harris, C.C., H. Autrup, G.D. Stoner, S.K. Yang, J.C. Leutz, H.V. Gelboin, J.K. Selkirk, R.J. Conner, L.A. Barrett, R.T. Jones, E.M. McDowell, and B.F. Trump. 1977. Metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a] anthracene in cultured human bronchus and pancreatic duct. Cancer Res. 37: 3349–3355.
Harris, C.C., H. Autrup, G.D. Stoner, B.F. Trump, E. Hillman, P.W. Schaefer, and A.M. Jeffrey. 1979. Metabolism of benzo[a]pyrene, N-nitrosodimethylamine, and N-nitrosopyrrolidine and identification of major carcinogen-DNA adducts formed in human esophagus. Cancer Res. 39: 4401–4406.
Autrup, H., C.C. Harris, B.F. Trump, and A.M. Jeffrey. 1978. Metabolism of benzo[a]pyrene and identification of major benzo[a]pyrene-DNA adducts in cultured human colon. Cancer Res. 38: 3689–3696.
Mass, M.J., N.T. Rodgers, and D.G. Kaufman. 1981. Benzo[a]pyrene metabolism in organ cultures of human endometrium. Chem.-Biol. Interact. 33: 195–205.
Harris, C.C., H. Autrup, R. Conner, L.A. Barrett, E.M. McDowell, and B.F. Trump. 1976. Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human bronchi. Science 194: 1067–1069.
Galofre, M.L., S.W. Payne, L.B. Woolner, 0.T. Clagett, and R.P. Gage. 1964. Pathologic classification and surgical treatment of bronchogenic carcinoma. Surg. Gynecol. Obstet. 119: 51–61.
Saffiotti, U., F. Cefis, and L.H. Kolb. 1968. A method for the experimental induction of bronchogenic carcinoma. Cancer Res. 28: 104–124.
Blair, W.H. 1974. Chemical induction of lung carcinomas in rats. In: Experimental Lung Cancer: Carcinogenesis and Bioassays. E. Karbe, and J.F. Parks, eds. Springer-Verlag: Berlin. pp. 199–206.
Schreiber, H., D.H. Martin, and N. Pazmino. 1975. Species differences in the effect of benzo[a]pyrene-ferric oxide on the respiratory tract of rats and hamsters. Cancer Res. 35: 1654–1661.
Blair, W.H., N. Otero, and H. Rao. 1973. Development of lung neoplasms in rats treated with 7,12-dimethylbenz[a]anthracene. Proc. Am. Assoc. Cancer Res. 14: 497.
Schreiber, H., P. Nettesheim, and D.H. Martin. 1972. Rapid development of bronchiolo-alveolar squamous cell tumors in rats after intratracheal injection of 3-methylcholanthrene. J. Natl. Cancer Inst. 49: 541–546.
Mossman, B.T., and J.E. Craighead. 1978. Induction of neoplasms in hamster tracheal grafts with 3-methylcholanthrene-coated Lycra fibers. Cancer Res. 38: 3717–3722.
Smith, J.M., M.B. Sporn, D.A. Berkowitz, T. Kakefuda, E. Callan, and U. Saffiotti. 1971. Isolation of enzymatically active nuclei from epithelial cells of the trachea. Cancer Res. 31: 199–202.
Schaffner, W., and C. Weissman. 1973. A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal. Biochem. 56: 502–515.
Yang, S.K., H.V. Gelboin, H. Autrup, and C.C. Harris. 1977. Metabolic activation of benzo[a]pyrene and binding to DNA in cultured human bronchus. Cancer Res. 37: 1210–1215.
DePierre, J.W., M.S. Moron, K.A.M. Johannesen, and L. Ernster. 1975. A reliable, sensitive, and convenient radioactive assay for benzpyrene monooxygenase. Anal. Biochem. 63: 470–484.
Burke, M.D., H. Metabolism of derivatives.Vadi, B. Jernstrom, and S. Orrenius. 1977. benzo[a]pyrene and degradation of DNA-binding J. Biol. Chem. 18: 6424–6431.
Sims, P. 1967. homogenates.The metabolism of benzo[a]pyrene by rat liver Biochem. Pharmacol. 16: 613–618.
Yang, S.K., and H.V. Gelboin. 1976. Nonenzymatic reduction of benzo[a]pyrene diol-epoxides to trihydroxypentahydrobenzo[a]pyrenes by reduced nicotinamide adenine dinucleotide phosphate. Cancer Res. 36: 4185–4189.
Mass, M.J., and D.G. Kaufman. 1979. Benzo[a]pyrene quinone metabolism in tracheal organ cultures. Biochem. Biophys. Res. Comm. 89: 885–892.
Nettesheim, P., R.A. Griesemer, D.H. Martin, and J.E. Caton. 1977. Induction of preneoplastic and neoplastic lesions in grafted hamster tracheas continuously exposed to benzo[a]pyrene. Cancer Res. 37: 1272–1278.
Prough, R.A., V.W. Patrizi, R.T. Okita, B.S.S. Masters, and S.W. Jakobsson. 1979. Characteristics of benzo[a]pyrene metabolism by kidney, liver, and lung microsomal fractions from rodents and humans. Cancer Res. 39: 1199–1206.
Mass, M.J., and D.G. Kaufman. 1978. [3H]Benzo[a]pyrene metabolism in tracheal epithelial cell microsomes and tracheal organ cultures. Cancer Res. 38: 3861–3866.
Simberg, N., and P. Uotila. 1978. Stimulatory effect of cigarette smoke on the metabolism and covalent binding of benzo[a]pyrene in the trachea of the rat. Int. J. Cancer 22: 28–31.
Cohen, G.M., and B.P. Moore. 1976. Metabolism of benzo[a]pyrene by different portions of the respiratory tract. Biochem. Pharmacol. 25: 1623–1629.
Cohen, G.M., A.C. Marchok, P. Nettesheim, V.E. Steele, F. Nelson, S. Huang, and J.K. Selkirk. 1979. Comparative metabolism of benzo[a]pyrene in organ and cell cultures derived from rat tracheas. Cancer Res. 39: 1980–1984.
Moore, B.P., and G.M. Cohen. 1978. Metabolism of [3H]BP and its major metabolites to ethyl-acetate-soluble and water-soluble metabolites by cultured rodent trachea. Cancer Res. 38: 3066–3075.
Autrup, H., F.C. Wefald, A.M. Jeffrey, H. Tate, R.D. Schwartz, B.F. Trump, and C.C. Harris. 1980. Metabolism of benzo[a]pyrene by cultured tracheobronchial tissues from mice, rats, hamsters, bovines, and humans. Int. J. Cancer 25: 293–300.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Plenum Press, New York
About this chapter
Cite this chapter
Mass, M.J., Kaufman, D.G. (1983). Species Differences in the Activation of Benzo[a]pyrene in the Tracheal Epithelium of Rats and Hamsters. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_18
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4400-1_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4402-5
Online ISBN: 978-1-4684-4400-1
eBook Packages: Springer Book Archive