Abstract
Tumor promoters are agents that, although not themselves carcinogenic, induce tumors in animals previously treated with a subthreshold dose of a carcinogen (1–3). Although tumor promotion has been characterized in greatest detail for mouse skin, it has also been demonstrated for the liver, bladder, colon, trachea, and mammary gland (4,5). The potential importance of tumor promotion in human cancer etiology is suggested by a growing body of epidemiological evidence (6–8).
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Blumberg, P.M., Delclos, K.B., Jaken, S. (1983). Tissue and Species Specificity for Phorbol Ester Receptors. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_11
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