Abstract
The exposure of luteal and testicular tissue in vivo to hCG has been shown to induce a rapid loss of sensitivity of adenylate cyclase (AC) to subsequent LH- or hCG-stimulations. The explanation for this phenomenon appears to be the loss of available receptor sites (1–4). However, the molecular mechanisms of the receptor loss are completely unknown.
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References
R.M. Sharpe. Nature 264 (1976) 644.
A.J.W. Hsueh, M.L. Dufau and K.J. Catt. Biochem.biophys. Res. Commun. 72 (1976) 1145.
M. Conti, J.P. Harwood, M.L. Dufau and K.J. Catt. Molec. Pharmacol. 13 (1977) 1024.
M.C. Rao, J.S. Richards, A.R. Midgley, Jr. and L.E. Reichert, Jr. Endocrinology 101 (1977) 512.
F.L. Leidenberger and L.E. Reichert, Jr. Endocrinology 91 (1972) 135.
C. Nakai and G. Brooker. Biochem.biophys.Acta (Amst.) 391 (1975) 222.
S. Markkanen, K. Töllikkö, T. Vanha-Perttula and H. Rajaniemi. Submitted for publication (1978).
S. Fazakerley and D.R. Best. Anal.Biochem. 12 (1965) 290.
M. Conti, J.P. Harwood, A.J.W. Hsueh, M.L. Dufau and K.J. Catt. J.Biol.Chem. 251 (1976) 7729.
M. Ascoli and D. Puett. FEBS Letters 75 (1977) 77.
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© 1979 Plenum Press, New York
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Rajaniemi, H.J., Jääskeläinen, K. (1979). Regulation of LH(hCG)-Receptor and Adenylate Cyclase in Luteinizing Granulosa Cells. In: Channing, C.P., Marsh, J.M., Sadler, W.A. (eds) Ovarian Follicular and Corpus Luteum Function. Advances in Experimental Medicine and Biology, vol 112. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3474-3_15
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DOI: https://doi.org/10.1007/978-1-4684-3474-3_15
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