Abstract
Successful application of proteins in therapy can be hampered by a multitude of difficulties. For instance, use, in the treatment of inherited metabolic disorders, of enzymes that are foreign to the body can promote immune reactions and occasionally fatal serum sickness. Such enzymes might even fail to penetrate, and act in, target areas either because of premature inactivation or because of target inaccessibility. Glucohydrolases, which are potentially useful in the treatment of most lysosomal storage diseases can, en route to their destination, act on their substrates located on cell surfaces or blood glycoproteins and thus upset normal metabolism (Gregoriadis et al., 1974a). Treatment of some forms of human leukemia with asparaginase can be jeopardized by allergic and other toxic reactions (Capizzi et al., 1970), and similar complications arise with the use of uricase in the treatment of gout. Indeed, it is perhaps correct to assume that most of these problems originate from our inability to direct therapeutic agents specifically to diseased areas. It follows that any approach enabling enzymes to reach their target selectively and in a controlled fashion would contribute to a safe and effective enzyme therapy.
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Gregoriadis, G. (1977). Liposomes as Carriers of Enzymes and Proteins in Medicine. In: Chang, T.M.S. (eds) Biomedical Applications of Immobilized Enzymes and Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2610-6_14
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DOI: https://doi.org/10.1007/978-1-4684-2610-6_14
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