Abstract
Protein production in the cell can be controlled principally at three levels: (1) by production of mRNA (transcriptional level); (2) through availability of mRNA for translation and modulation of mRNA translation rate (translational level); and (3) by mRNA elimination (degradation). Although both transcription and mRNA degradation may also depend on ribosomes, only the translational level of protein synthesis regulation will be considered here.
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Adhin, M. R., and van Duin, J. (1989) Translational regulation of the lysis gene in RNA bacteriophage fr requires a UUG initiation codon, Mol. Gen. Genet. 218:137–142.
Adhin, M. R., and van Duin, J. (1990) Scanning model for translational reinitiation in Eubacteria, J. Mol. Biol. 213:811–818.
Aiba, H., Matsuyama, S.-L, Mizumo, T., and Mizushima, S. (1987) Function of micF as an antisense RNA in osmoregulatory expression of the ompF gene in Escherichia coli, J. Bacteriol. 169:3007–3012.
Bernardi, A. and Spahr, P. F. (1972) Nucleotide sequence at the binding site for coat protein on RNA of bacteriophage R17, Proc. Natl. Acad. Sci. USA 69:3033–3037.
Brunei, C., Romby, P., Sacerdot, C., de Smit, M., Graffe, M., Dondon, J., van Duin, J., Ehresmann, B., Ehresmann, C., and Springer, M. (1995) Stabilised secondary structure at a ribosomal binding site enhances translational repression in E. coli, J. Mol. Biol. 253:277–290.
Das, A., and Yanofsky, C. (1984) A ribosome binding site sequence is necessary for efficient expression of the distal gene of a translationally-coupled gene pair, Nucl. Acids Res. 12:4757–4768.
de Smit, M. H., and van Duin, J. (1990) Control of prokaryotic translational initiation by mRNA secondary structure, Progr. Nucleic Acid Res. Mol. Biol. 38:1–35.
Dean, D., and Nomura, M. (1980) Feedback regulation of ribosomal protein gene expression in Escherichia coli, Proc. Natl. Acad. Sci. USA 77:3590–3594.
Dean, D., Yates, J. L., and Nomura, M. (1981a) Escherichia coli ribosomal protein S8 feedback regulates part of spc operon, Nature 289:89–91.
Dean, D., Yates, J. L., and Nomura, M. (1981b) Identification of ribosomal protein S7 as a repressor of translation within the str operon of E. coli, Cell 24:413–419.
Draper, D. E. (1987) Translational regulation of ribosomal proteins in Escherichia coli: Molecular mechanisms, in Translational Regulation of Gene Expression (J. Ilan, ed.), pp. 1–26, Plenum Press, New York and London.
Friesen, J. D., Fiil, N. P., Dennis, P. P., Downing, W. L., An, G., and Holowachuk, E. (1980) Biosynthetic regulation of rplJ, rolL, rpoB and rpoC in Escherichia coli, in Ribosomes: Structure, Function, and Genetics (G. Chamblis, G. R. Craven, J. Davies, K. Davis, L. Kahan, and M. Nomura, eds.), pp. 719–742, University Park Press, Baltimore.
Gold, L. (1988) Posttranscriptional regulatory mechanisms in Escherichia coli, Annu. Rev. Biochem. 57:199–233.
Gualerzi, C., la Teana, A., Spurio, R., Canonaco, M. A., Severini, M., and Pon, C. L. (1990) Initiation of protein biosynthesis in procaryotes: Recognition of mRNA by ribosomes and molecular basis for the function of initiation factors, in The Ribosome: Structure, Function, and Evolution (W. E. Hill, A. Dahlberg, R. A. Garrett, P. B. Moore, D. Schlessinger, and J. R. Warner, eds.), pp. 281–291, ASM Press, Washington, DC.
Hellmuth, K., Rex, G., Surin, B., Zinck, R., and McCarthy, J. E. G. (1991) Translational coupling varying in efficiency between different pairs of genes in the central region of the atp operon of Escherichia coli, Mol. Microbiol. 5:813–824.
Inouye, M. (1988) Antisense RNA: its functions and applications in gene regulation—a review, Gene 72:25–34.
Ivey-Hoyle, M., and Steege, D. A. (1989) Translation of phage f1 gene VII occurs from an inherently defective initiation site made functional by coupling, J. Mol. Biol. 208:233–244.
Johnsen, M., Christensen, T., Dennis, P. P., and Fiil, N. P. (1982) Autogenous control: Ribosomal protein L10–L12 complex binds to the leader sequence of its mRNA, EMBO J. 1:999–1004.
Kolakofsky, D., and Weissmann, C. (1971) Possible mechanism for translation of viral RNA from polysome to replication complex, Nature New Biol. 231:42–46.
Lindahl, L., and Zengel, J. (1982) Expression of ribosomal genes in bacteria, in Advances in Genetics (E. W. Caspari, ed.), vol. 21, pp. 53–111, Academic Press, New York.
Lindahl, L., and Zengel, J. M. (1986) Ribosomal genes in Escherichia coli, Annu. Rev. Biochem. 20:297–326.
Lodish, H. F., and Robertson, H. D. (1969) Regulation of in vivo translation of bacteriophage f2 RNA, Cold Spring Harbor Symp. Quant. Biol. 34:655–673.
Lodish, H. F., and Zinder, N. D. (1966) Mutants of the bacteriophage f2. VIII. Control mechanisms for phage-specific syntheses, J. Mol. Biol. 19:333–348.
Ma, C., and Simons, R. W. (1990) The IS10 antisense RNA blocks ribosome binding at the transposase translation initiation site, EMBO J. 9:1267–1274.
Malmgren, C., Engdahl, H. M., Romby, P., and Wagner, E. G. H. (1996) An antisense/target RNA duplex or a strong intramolecular RNA structure 5′ of a translation initiation signal blocks ribosome binding: The case of plasmid R1. RNA 2:1022–1032.
McCarthy, J. E. G. (1988) Expression of the unc genes in Escherichia coli, J. Bioenerg. Biomembr. 20:19–39.
McCarthy, J. E. G. (1990) Post-transcriptional control in the polycistronic operon environment: studies of the atp operon of Escherichia coli, Mol. Microbiol. 4:1233–1240.
McCarthy, J. E. G., and Brimacombe, R. (1994) Prokaryotic translation: the interactive pathway leading to initiation, Trends Genet. 10:402–407.
McCarthy, J. E. G., and Gualerzi, C. (1990) Translational control of prokaryotic gene expression, Trends Genet 6:78–85.
Meyer, F., Weber, H., and Weissmann, C. (1981) Interactions of Qβ replicase with Qβ RNA, J. Mol. Biol. 153:631–660.
Mizuno, T., Chou, M.-Y., and Inouye, M. (1984) A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA), Proc. Natl. Acad. Sci. USA 81:1966–1970.
Moine, H., Romby, P., Springer, M., Grunberg—Manago, M., Ebel, J. P., Ehresmann, C., and Ehresmann, B. (1988) Messenger RNA structure and gene regulation at the translational level in Escherichia coli: The case of threonine:tRNAThe ligase, Proc. Natl. Acad. Sci. USA 85:7892–7896.
Moine, H., Romby, P., Springer, M., Grunberg-Manago, M., Ebel, J.-P, Ehresmann, B., and Ehresmann, C. (1990) Escherichia coli threonyl-tRNA synthetase and tRNAThr modulate the binding of the ribosome to the translational initiation site of the ThrS mRNA, J. Mol. Biol. 216:299–310.
Nomura, M., Gourse, R., and Baughman, G. (1984) Regulation of the synthesis of ribosomes and ribosomal components, Annu. Rev. Biochem. 53:75–117.
Nomura, M., Jinks-Robertson, S., and Miura, A. (1982) Regulation of ribosome biosynthesis in Escherichia coli, in Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression (M. Grunberg-Manago and B. Safer, eds.), pp. 91–104, Elsevier, New York.
Nomura, M., Yates, J. L., Dean, D., and Post, L. E. (1980) Feedback regulation of ribosomal protein gene expression in Escherichia coli: Structural homology of ribosomal RNA and ribosomal protein mRNA, Proc. Natl. Acad. Sci. USA 77:7084–7088.
Olins, P. O., and Nomura, M. (1981) Translational regulation by ribosomal protein S8 in Escherichia coli: Structural homology between rRNA binding site and feedback target on mRNA, Nucl. Acids Res. 9:1757–1764.
Oppenheim, D. S., and Yanofsky, C. (1980) Translational coupling during expression of the tryptophan operon of Escherichia coli, Genetics 95:785–795.
Petersen, C. (1989) Long-range translational coupling in the rplJL-rpoBC operon of Escherichia coli, J. Mol. Biol. 206:323–332.
Platt, T., and Yanofsky, C. (1975) An intercistronic region and ribosome-binding site in bacterial messenger RNA, Proc. Natl. Acad. Sci. USA 72:2399–2403.
Portier, C., and Grunberg-Manago, M. (1993) Regulation of ribosomal protein mRNA translation in bacteria: The case of S15, in Translational regulation of gene expression 2 (J. Ilan, ed.), pp. 23–47, Plenum Press, New York, London.
Robertson, H. D., and Lodish, H. F. (1970) Messenger characteristics of nascent bacteriophage RNA, Proc. Natl. Acad. Sci. USA 67:710–716.
Sarabhai, A., and Brenner, S. (1967) A mutant which reinitiates the polypeptide chain after chain termination, J. Mol. Biol. 27:145–162.
Schumperli, D., McKenney, K., Sobieski, D. A., and Rosenberg, M. (1982) Translational coupling at an intercistronic boundary of the Escherichia coli galactose operon, Cell 30:865–871.
Simons, R. W., and Kleckner, N. (1983) Translational control of IS10 transposon, Cell 34:683–691.
Springer, M., and Grunberg-Manago, M. (1987) Escherichia coli threonyl-transfer RNA synthetase as a model system to study translational autoregulation in prokaryotes, in Translational Regulation of Gene Expression (J. Ilan, ed.), pp. 51–61, Plenum Press, New York, London.
Steitz, J. A. (1980) RNA·RNA interactions during polypeptide chain initiation, in Ribosomes: Structure, Function, and Genetics (G. Chambliss, G. R. Craven, J. Davies, K. Davis, L. Kahan, and M. Nomura, eds.), pp. 479–495, University Park Press, Baltimore.
Stormo, G. D. (1986) Translation initiation, in Maximizing Gene Expression (W. Reznikoff and L. Gold, eds.), pp. 195–224, Butterworths, Boston, London.
Stormo, G. D. (1987) Translational regulation of bacteriophages, in Translational Regulation of Gene Expression (J. Ilan, ed.), pp. 27–49, Plenum Press, New York, London.
Voorma, H. O. (1996) Control of translation initiation in prokaryotes, in Translational Control (J. W. B. Hershey, M. B. Mathews, and N. Sonenberg, eds.), pp. 759–777, Cold Spring Harbor Laboratory Press, New York.
Wagner, E. J., and Simons, R. W. (1994) Antisense RNA control in bacteria, phages, and plasmids, Annu. Rev. Microbiol. 48:713–742.
Weber, H., Billeter, M. A., Kahane, S., Weissmann, C., Hindley, J., and Porter, A. (1972) Molecular basis for repressor activity of Qβ replicase, Nature New Biol. 237:166–169.
Weissmann, C., Billeter, M. A., Goodman, H. M., Hindley, J., and Weber, H. (1973) Structure and function of phage RNA, Annu. Rev. Biochem. 42:303–328.
Yates, J. L., Dean, D., Strycharz, W. A., and Nomura, M. (1981) E. coli ribosomal protein L10 inhibits translation of L10 and L7/L12 mRNAs by acting at a single site, Nature 294:190–192.
Yates, J. L., and Nomura, M. (1980) E.coli ribosomal protein L4 is a feedback regulatory protein, Cell 21:517–522.
Yates, J. L., and Nomura, M. (1981) Feedback regulation of ribosomal protein synthesis in E. coli: Localization of the mRNA target sites for repressor action of ribosomal protein L1, Cell 24:243–249.
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Spirin, A.S. (1999). Translational Control in Prokaryotes. In: Ribosomes. Cellular Organelles. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7817-8_16
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DOI: https://doi.org/10.1007/978-1-4615-7817-8_16
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