Abstract
Morphological and quantitative assessment of coronary artery disease in vivo represents an important, although difficult, challenge in cardiovascular research and clinical practice. Until recently, atherosclerotic coronary lesions could not be visualized directly by any available imaging modality. Accordingly, detection of coronary obstructions has relied principally upon indirect methods that either depict the vessel lumen (angiography) or expose the ischemic effect of coronary narrows (nuclear or stress echocardiography). However, both methods are insensitive to the early, minimally obstructive disease associated with the dramatic and often lethal consequences of coronary atherosclerosis — acute coronary syndromes.
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Nissen, S., Klein, L.W. (1997). Intravascular Ultrasound: Equipment, Technique and Applications in Clinical Practice and Research. In: Klein, L.W. (eds) Coronary Stenosis Morphology: Analysis and Implication. Developments in Cardiovascular Medicine, vol 190. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6287-0_2
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DOI: https://doi.org/10.1007/978-1-4615-6287-0_2
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