Abstract
Aldehyde dehydrogenases are NAD-dependent enzymes that catalyze the oxidation of aldehydes to carboxylic acids. Three major classes of mammalian aldehyde dehydrogenase (ALDH) are recognized (Lindahl, 1992). Class 1 is cytosolic and NAD-specific. Class 2 is mitochondrial, also uses NAD, and preferentially functions at micromolar concentrations of small aliphatic aldehydes. Class 1 and 2 are tetramers of identical subunits. The monomers have a molecular weight of 55 kD. Class 3 ALDH preferentially uses NAD, but can use NADP. Class 3 oxidizes aromatic aldehydes such as benzaldehyde. The enzyme is a dimer of identical monomers with molecular weights of 50kD.
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© 1996 Springer Science+Business Media New York
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Settles, H.E., Boesch, J.S., Lindahl, R.G. (1996). Organ Distribution of Aldehyde Dehydrogenase Activity in the Newt. In: Weiner, H., Lindahl, R., Crabb, D.W., Flynn, T.G. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 6. Advances in Experimental Medicine and Biology, vol 414. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5871-2_13
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DOI: https://doi.org/10.1007/978-1-4615-5871-2_13
Publisher Name: Springer, Boston, MA
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