Abstract
We previously measured the hydrogen ion [H+], bicarbonate ion concentration [HCO3 -], and PCO2, in the arterial blood of elderly patients, and examined the correlation of [H+] and [HCO3 -] with PCO2. We found that the deviations of [H+] and [HCO3 -] from their respective regression lines versus PCO2 were well correlated with each other. When the deviation was close to zero, the deviation of [HCO3 -] was linearly related with that of [H+]. This result suggested that the ratio of [HCO)3 -] to [H+] on the regression line was constant. Later we found in normal venous plasma that the ratio of [H+] to [HCO3 -] was distributed in a narrow range around 1.53 x 10-6 (Mochizuki, 1995). It has been suggested that the measured [H+] value had a Peal-dependent [H+]* and a Peal-independent component Δ[H+], and the [H+]* could be approximated by an expression that was proportional to the square root of Peo2 using the Henderson equation (Henderson, 1909). Then, Δ[H+] was obtained by subtracting [H+]* from [H+]. From the relationship of Δ[H+] between arterial and venous blood, we confirmed that the Δ[H+] remains unchanged despite a change in Peo, in the lung. Using the slope of the regression line of the V-A difference in Δ[H+] plotted-against that in PCO [H+]* could be determined. When the[H+]* was known for an exponential function of PCO2 the regression line of the V-A difference of Δ[H+] lay upon the abscissa, which veri fied that Δ[H+] was independent of PCO2.
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Mochizuki, M. (1998). A Proposal for Analysing the Acid-Base Balance at Steady State in Vivo. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_4
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DOI: https://doi.org/10.1007/978-1-4615-4863-8_4
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