Abstract
Generally speaking, Ca2+ influx through membrane in smooth muscle cells may play a crucial role in Excitation-Contraction Coupling. Mammalian smooth muscle cells are universally endowed with a lot of L-type, dihydropyridine-sensitive voltage-dependent Ca2+ channels and various kinds of K+ channels. Actually, Ca2+ conductances are increased by membrane depolarization causing Ca2+ influx and subsequent contraction.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Benham, C.D., Bolton, T.B. and Lang, R.J., 1985, Acetylcholine activates an inward current in single mammalian smooth muscle cells, Nature, 316: 345–347.
Hamill, O.P., Marty, A., Neher, E., Sakmann, B. and Sigworth, F.J., 1981, Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch., 391: 85–100.
Hescheler, J., Mieskes, G., Rüegg, J.C., Takai, A. and Trautwein, W., 1988, Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes, Pflüqers Arch., 412: 248–252.
Isenberg, G. and Klockner, U., 1982, Calcium tolerant ventricular myocytes prepared by preincubation in a “KB Medium”, Pflügers Arch., 395: 6–18.
Ishihara, H., Martin, B.L., Brautigan, D.L., Karaki, H., Ozaki, H., Kato, Y., Fusetani, N., Watabe, S., Hashimoto, K., Uemura, D. and Hartshorne, D.J., 1989, Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity, Biochem. Biophys. Res. Commun., 159: 871–877.
Ishihara, H., Ozaki, H., Sato, K., Hori, M., Karaki, H., Watabe, S., Kato, Y., Fusetani, N., Hashimoto, K., Uemura, D. and Hartshorne, D.J., 1989, Calcium-independent activation of contractile apparatus in smooth muscle by calyculin-A, J. Pharmacol. Exp. Ther., 250: 388–396.
Kameyama, M., Hescheler, J., Hofmann, F. and Trautwein, W., 1986, Modulation of Ca current during the phosphorylation cycle in the guinea pig heart, Pflügers Arch., 407: 123–128.
Kato, Y., Fusetani, N., Matsunaga, S. and Hashimoto, K., 1986, Calyculin A, a novel antitumor metabolite from the marine sponge Discodermia calyx, J. Am. Chem. Soc., 108: 2780–2781.
Obara, K., 1984, Isolation and contractile properties of single smooth muscle cells from guinea pig taenia caeci, Jpn. J. Physiol., 34: 41–54.
Ohya, Y., Kitamura, K. and Kuriyama, H., 1987, Modulation of ionic currents in smooth muscle balls of the rabbit intestine by intracellular perfused ATP and cyclic AMP, Pflügers Arch., 408: 465–473.
Ozaki, H., Kojima, T., Moriyama, T., Karaki, H., Urakawa, N., Kohama, K. and Nonomura, Y., 1987, Inhibition by amiloride of contractile elements in smooth muscle of guinea pig taenia cecum and chicken gizzard, J. Pharmacol. Exp. Ther., 243: 370–377.
Yabu, H., Yoshino, M., Usuki, T., Someya, T., Obara, K., Ozaki, H. and Karaki, H., 1990, Modification by calyculin A of inward Ca currents in smooth muscle cells isolated from guinea pig taenia coli, in: “Frontiers in Smooth Muscle Research”, N. Sperelakis and J.D. Wood, eds., pp623–626, Wiley-Liss, New York.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Yabu, H., Obara, K., Usuki, T. (1992). Calcium and Potassium Channel Regulation by Protein Phosphorylation in Smooth Muscle Cells of Guinea Pig Taenia Coli. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_4
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3362-7_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6483-2
Online ISBN: 978-1-4615-3362-7
eBook Packages: Springer Book Archive