Abstract
The growing number of bioactive substances being found in human milk suggest the need to attempt their categorization according to function. Two major themes that emerge from recent research on human milk and lactation are efficient nutrient transfer from mother to infant and protection of the infant from disease. Bioactive substances in human milk may be considered in terms of these themes.
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Akin DT, Lu MQ, Lu SJ, Kendall S, Rundegren J, Arnold RR. Bactericidal activity of different forms of lactoferrin. Adv Exp Med Biol 1994;357:61–70.
Brock JH. Lactoferrin in human milk: its role in iron absorption and protection against enteric infection in the newborn infant. Arch Dis Child 1980;55:417–421.
Buescher ES, Malinowska I. Soluble receptors and cytokine antagonists in human milk. Pediatr Res 1996;40:839–844.
Buescher ES, Mcllheran SM. Antioxidant properties of human colostrum. Pediatr Res 1988;24:14–19.
Buescher ES, Mcllheran SM. Polymorphonuclear leukocytes and human colostrum: effects of in vivo and in vitro exposure. J Pediatr Gastroenterol Nutr 1993;17:424–433.
Ellis LA, Mastro AM, Picciano MF. Milk-borne prolactin and neonatal development. J Mammary Gland Biol Neoplasia 1996;1:259–269.
Ellis LA, Mastro AM, Picciano MF. Do milk-borne cytokines and hormones influence neonatal immune cell function? J Nutr 1997;127:985S–988S.
Goldman AS, Chheda S, Garofalo R, Schmalstieg FC. Cytokines in human milk: Properties and potential effects upon the mammary gland and the neonate. J Mammary Gland Biol Neoplasia 1996;1:251–258.
Grulee C, Sanford H, Schwartz H. Breast and artificially fed infants; study of the age incidence in the morbidity and mortality in 20,000 cases. JAMA 1935;104:1986–1988.
Gyorgy P, Jeanloz RW, Von Nicolai H, Zilliken F. Undialyzable growth factors forLactobacillus bifidus var. pennsylvanicus.Protective effect of sialic acid bound to glycoproteins and oligosaccharides against bacterial degradation. Eur J Biochem 1974;43:29–33.
Montreuil J, Mullet S. Etude des variations des constituants glucidiques du lait de femme au cours de la lactation. Bulletin de la Societe de Chimie Biologique 1960;42:365–377.
Newburg DS. Oligosaccharides and glycoconjugates in human milk: Their role in host defense. J Mammary Gland Biol Neoplasia 1996;1:271–283.
Newburg DS, Chaturvedi P. Neutral glycolipids of human and bovine milk. Lipids 1992;27:923–927.
Newburg DS, Linhardt RJ, Ampofo SA, Yolken RH. Human milk glycosaminoglycans inhibit HIV glycoprotein gp120 binding to its host cell CD4 receptor. J Nutr 1995;125:419–424.
Newburg DS, Pickering LK, McCluer RH, Cleary TG. Fucosylated oligosaccharides of human milk protect suckling mice from heat-stabile enterotoxin ofEscherichia coll.J Infect Dis 1990;162:10751080.
Ogra SS, Ogra PL. Immunologic aspects of human colostrum and milk. I. Distribution characteristics and concentrations of immunoglobulins at different times after the onset of lactation. J Pediatr 1978; 92:546–549.
Ogra SS, Ogra PL. Components of immunologic reactivity in human colostrum and milk. In: Ogra PL, Dayton D, editors. Immunology of Breast Milk. New York: Raven Press; 1979; pp. 185–193.
Otnaess A-BK, Laegreid A, Ertresvag K. Inhibition of enterotoxin fromEscherichia coliandVibrio choleraeby gangliosides from human milk. Infect Immun 1983;40:563–569.
Patton S, Gendler SJ, Spicer AP. The epithelial mucin, MUC1, of milk, mammary gland and other tissues. Biochim Biophys Acta 1995;1241:407–423.
Stahl B, Thurl S, Zeng J, Karas M, Hillenkamp F, Steup M, Sawatzki G. Oligosaccharides from human milk as revealed by matrix-assisted laser desorption/ionization mass spectrometry. Anal Biochem 1994;223:218–226.
Thormar H, Isaacs CE, Brown HR, Barshatzky MR, Pessolano T. Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob Agents Chemother 1987;31:27–31.
Thormar H, Isaacs CE, Kim KS, Brown HR. Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides. Ann N Y Acad Sci 1994;724:465–471.
Wilson EO. Sociobiology. Cambridge, Massachusetts: Harvard University Press, 1980.
Yolken RH, Peterson JA, Vonderfecht SL, Fouts ET, Midthun K, Newburg DS. Human milk mucin inhibits rotavirus replication and prevents experimental gastroenteritis. J Clin Invest 1992;90:1984–1991.
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Newburg, D.S. (2001). Bioactive Components of Human Milk. In: Newburg, D.S. (eds) Bioactive Components of Human Milk. Advances in Experimental Medicine and Biology, vol 501. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1371-1_1
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DOI: https://doi.org/10.1007/978-1-4615-1371-1_1
Publisher Name: Springer, Boston, MA
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