Abstract
The common therapeutic approach to septicemia - aside from elimination of its cause and antibiosis - consists of the attempt to keep tissue perfusion within physiological limits. A frequently employed therapeutic option is catecholamine administration. Since the reduction of peripheral vascular resistance in septicemia is at least partly due to a TNF induced vascular NO-synthase, the inhibition of this system does affect tissue perfusion as well. While there are controversial results as to the benefit of inhibition of NO-synthase on mean arterial pressure (MAP) and cardiac index (CI) (1) the effect of NO-synthase inhibition on liver circulation has not been described. In addition we were interested in the effect of NO-synthase inhibition on liver pO2.
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© 1996 Plenum Press, New York
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Wagner, K., Schäfer, R., Gerling, W., Michelsen, A., Schmucker, P. (1996). Comparison Between Conventional Hemodynamic Monitoring and Polarographic Tissue PO2-Monitoring of the Liver in Early Septicemia of the Pig. In: Ince, C., Kesecioglu, J., Telci, L., Akpir, K. (eds) Oxygen Transport to Tissue XVII. Advances in Experimental Medicine and Biology, vol 388. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0333-6_10
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DOI: https://doi.org/10.1007/978-1-4613-0333-6_10
Publisher Name: Springer, Boston, MA
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Online ISBN: 978-1-4613-0333-6
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