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Connectivity of Transplants in the Cerebellum: A Model of Developmental Differences in Neuroplasticity

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Neural Tissue Transplantation Research

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

The problem of mammalian central nervous system (CNS) regeneration has been a cynosure for neurobiologists for nearly a century. Different types of central neurons have been shown to differ in their response to direct injury. Some, namely, the weakly myelinated monoaminergic systems, maintain considerable reGenerative capacity through adulthood (reviewed in Björklund and Stenevi 1979). Others, such as the long myelinated systems of the spinal cord, exhibit nearly none. While the current consensus on the capacity of most intrinsic CNS neurons to exhibit true regeneration remains pessimistic, demonstrations of a similar response, compensatory sprouting of residual fibers in response to partial denervation, have gained general acceptance. Clearly, in many respects, these forms of a sprouting response are inherently similar since both involve the active elongation of axons.

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Authors and Affiliations

  1. Department of Anatomy, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106, USA

    Monica M. Oblinger

  2. Department of Biological Sciences, Purdue University, West Lafayette, Indiana, 47907, USA

    Gopal D. Das

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  1. Monica M. Oblinger
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  1. Departments of Psychology and Biology, University of Hartford, West Hartford, Connecticut, 06117, USA

    Robert B. Wallace

  2. Department of Biological Sciences, Purdue University, West Lafayette, Indiana, 47907, USA

    Gopal D. Das

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Oblinger, M.M., Das, G.D. (1983). Connectivity of Transplants in the Cerebellum: A Model of Developmental Differences in Neuroplasticity. In: Wallace, R.B., Das, G.D. (eds) Neural Tissue Transplantation Research. Proceedings in Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5539-0_3

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