Abstract
There are two causes of failure in the surgical treatment of metastatic tumors: first, local recurrence of the tumor is not always prevented, even after extra-tumoral surgical exeresis and systemic chemotherapy, and secondly, failure of osteosynthesis after surgery. For these reasons, we thought that it would be helpful to provide local chemotherapy during and immediately after surgery, for instance, by adding an antimitotic to the acrylic cement used to replace the bone loss or to seal reconstruction prostheses. It was thought that the antimitotic would be likely to be released into the surrounding tissues in the same way as many antibiotics. Diffusion into the surrounding tissues is well established for numerous antibiotics [1–6].
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Hernigou, P. (2004). Cement with Antimitotics. In: Poitout, D.G. (eds) Biomechanics and Biomaterials in Orthopedics. Springer, London. https://doi.org/10.1007/978-1-4471-3774-0_10
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DOI: https://doi.org/10.1007/978-1-4471-3774-0_10
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