Abstract
There are two causes of failure in the surgical treatment of bone tumors. One is local recurrence of the tumor, which is not always avoidable, even after wide surgical excision and systemic chemotherapy. The other is difficulty in controlling metastases after surgical treatment. For these reasons, chemotherapy treatment is now recommended preoperatively, and it is continued as soon as possible after definitive surgery but not, in theory, before skin healing has taken place. To limit the postoperative period with chemotherapy, we thought that it would be interesting to apply perioperative and immediate postoperative chemotherapy by adding an antimitotic agent to the acrylic cement used to fill the loss of bone substance or to fix reconstructive prostheses, as is already done with many antibiotics, which would diffuse into the surrounding tissues.
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Hernigou P, Thiery JP, Benoit J, et al. Release of antimitotic drugs from acrylic cement and plaster. Eur Surg Res 19(Suppl 1):25, 1987.
Hernigou P, Thiery JP, Benoist M, et al. Etude expérimentale sur l’ostéosarcome d’une chimiothérapie locale diffusant à partir de ciment acrylique chirurgical et de plâtre. Rev Chir Orthop 73:517–525, 1987.
Hernigou P, Thiery JP, Benoit, J. et al. Diffusion of methotrexate from surgical acrylic cement. Bone Joint Surg [Br] 71B:804–811, 1989.
Hernigou P, Brun P, Thiery JP, et al. Antimitotic loaded acrylic cement. In: Limb Salvage. Langlais F., Ed. Springer Verlag, Berlin, 1991.
Langendorff HU. Cytostatic bone cement. In: New Developments for Limb Salvage in Musculoskeletal Tumors. Yamamuro T, Ed. Springer Verlag, Berlin, 1989.
Janmin Li. Experimental observations on acrylic bone cement containing antitumor drugs. Natl Med J China 69:143, 1989.
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© 1993 Springer Science+Business Media New York
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Hernigou, P., Brun, B., Astier, A., Goutallier, D., le Bourgeois, J.P. (1993). Diffusion of methotrexate from surgical acrylic cement. In: Humphrey, G.B., Koops, H.S., Molenaar, W.M., Postma, A. (eds) Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies. Cancer Treatment and Research, vol 62. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3518-8_26
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DOI: https://doi.org/10.1007/978-1-4615-3518-8_26
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