Abstract
In this chapter we describe work stemming from the development of a stoichiometrically-constrained model of Escherichia coli metabolism, to experimental evolution of strains, to the analysis of the function of acquired adaptive mutations with the goal of understanding their system-wide effect on phenotype.
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Applebee, M.K., Palsson, B.Ø. (2009). Genome-Scale Models and the Genetic Basis for E. coli Adaptation. In: Lee, S.Y. (eds) Systems Biology and Biotechnology of Escherichia coli . Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9394-4_12
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DOI: https://doi.org/10.1007/978-1-4020-9394-4_12
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