Brain-computer interfaces (BCI), or brain-machine interfaces (BMI), are systems designed to aid humans with central nervous system disabilities, including disabilities in movement, communication, and independent control of one’s environment (Donoghue, 2002; Friehs et al., 2004; Lebedev and Nicolelis, 2006; Schwartz et al., 2006). Although these same approaches have the potential to augment normal function, as currently envisioned this new class of biomedical devices is being developed to help those with disabilities. As such, these devices may be useful for patients suffering from a variety of conditions including spinal cord injury, musculodegenerative diseases, stroke, amyotrophic lateral sclerosis, or other neurological or neuromuscular diseases. The intent of these devices and their associated components is to provide or supplement motor or sensory function that has been lost. The theoretical basis for such devices lies in our ability to detect neural signals and translate volitional commands into control signals for external devices including computers, robotics, or other machines. The acquisition of neural signals has traditionally occurred in the cerebral cortex, and the recording of these signals from implanted electrodes has a fairly extensive history.
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Keywords
- Amyotrophic Lateral Sclerosis
- Electrode Array
- Recording Electrode
- Neuronal Cell Body
- Microelectrode Array
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References
Babb, T.L. and W. Kupfer. 1984. Phagocytic and metabolic reactions to chronically implanted metal brain electrodes, Exp. Neurol. 86(2):171–182.
Bickford, R.G., G. Fischer, and G.P. Sayre. 1957. Histologic changes in the cat's brain after introduction of metallic and plastic coated wire used in electro-encephalography. Mayo Clin. Proc. 32(1):14–21.
Biran, R., D.C. Martin, and P.A. Tresco. 2007. The brain tissue response to implanted silicon microelectrode arrays is increased when the device is tethered to the skull. J. Biomed. Mater. Res. Part A82A(1):169–178.
Biran, R., D.C. Martin, and P.A. Tresco. 2005. Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays. Exp. Neurol. 195(1):115–126.
Bjornsson, C.S., S.J. Oh, Y.A. Al-Kofahi, Y.J. Lim, K.L. Smith, J.N. Turner, S. De, B. Roysam, W. Shain, and S.J. Kim. 2006. Effects of insertion conditions on tissue strain and vascular damage during neuroprosthetic device insertion. J. Neural Eng. 3(3):196–207.
Burns, B.D., J.P. Stean, and A.C. Webb. 1974. Recording for several days from single cortical neurons in completely unrestrained cats. Electroencephalogr. Clin. Neurophysiol. 36(3): 314–318.
Buzsaki, G., and A. Kandel. 1998. Somadendritic backpropagation of action potentials in cortical pyramidal cells of the awake rat. J. Neurophysiol. 79(3):1587–1591.
Collias, J.C., and E.E. Manuelidis. 1957. Histopathological changes produced by implanted electrodes in cat brains; Comparison with histopathological changes in human and experimental puncture wounds. J. Neurosurg. 14(3):302–328.
Cui, X., V.A. Lee, Y. Raphael, J.A. Wiler, J.F. Hetke, D.J. Anderson, and D.C. Martin. 2001. Surface modification of neural recording electrodes with conducting polymer/biomolecule blends. J. Biomed. Mater. Res. 56(2):261–272.
Cui, X., J. Wiler, M. Dzaman, R.A. Altschuler, and D.C. Martin. 2003. In vivostudies of polypyrrole/peptide coated neural probes. Biomaterials24(5):777–787.
Donoghue, J.P. 2002. Connecting cortex to machines: Recent advances in brain interfaces. Nature Neurosci. 5:1085–1088.
Dymond, A.M., L.E. Kaechele, J.M. Jurist, and P.H. Crandall. 1970. Brain tissue reaction to some chronically implanted metals. J. Neurosurg. 33(5):574–580.
Edell, D.J., V.V. Toi, V.M. McNeil, and L.D. Clark. 1992. Factors influencing the biocompatibility of insertable silicon microshafts in cerebral cortex. IEEE Trans. Biomed. Eng. 39(6):635–643.
Friehs, G.M., V.A. Zerris, C.L. Ojakangas, M.R. Fellows, and J.P. Donoghue. 2004. Brainmachine and brain-computer interfaces. Stroke35(11 Suppl 1):2702–2705.
He, W. and R.V. Bellamkonda. 2005. Nanoscale neurointegrative coatings for neural implants. Biomaterials26(16):2983–2990.
He, W., G.C. McConnell, and R.V. Bellamkonda. 2006. Nanoscale laminin coating modulates cortical scarring response around implanted silicon microelectrode arrays. J. Neural Eng. 3(4):316–326.
Hendriks, J.J., C.E. Teunissen, H.E. de Vries, and C.D. Dijkstra. 2005. Macrophages and neurodegeneration. Brain Res. Brain Res. Rev. 48(2):185–195.
Henze, D.A., Z. Borhegyi, J. Csicsvari, A. Mamiya, K.D. Harris, and G. Buzsaki. 2000. Intracellular features predicted by extracellular recordings in the hippocampus in vivo. J. Neurophysiol. 84(1):390–400.
Hochberg, L.R., M.D. Serruya, G.M. Friehs, J.A. Mukand, M. Saleh, A.H. Caplan, A. Branner, D. Chen, R.D. Penn, and J.P. Donoghue. 2006. Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature442(7099):164–171.
Hoogerwerf, A.C. and K.D. Wise. 1994. A three-dimensional microelectrode array for chronic neural recording. IEEE Trans. Biomed. Eng. 41(12):1136–1146.
Kennedy, P.R., R.A. Bakay, M.M. Moore, K. Adams, and J. Goldwaithe. 2000. Direct control of a computer from the human central nervous system. IEEE Trans. Rehab. Eng. 8(2):198–202.
Kim, D.H. and D.C. Martin. 2006. Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery. Biomaterials27(15):3031–3037.
Kralik, J.D., D.F. Dimitrov, D.J. Krupa, D.B. Katz, D. Cohen, and M.A. Nicolelis. 2001. Techniques for long-term multisite neuronal ensemble recordings in behaving animals. Methods25(2):121–150.
Lebedev, M.A. and M.A. Nicolelis. 2006. Brain-machine interfaces: past, present and future, Trends Neurosci. 29(9):536–546.
Lee, H., R.V. Bellamkonda, W. Sun, and M.E. Levenston. 2005a. Biomechanical analysis of silicon microelectrode-induced strain in the brain. J. Neural Eng. 2(4):81–89.
Lee, I.H., E. Lindqvist, O. Kiehn, J. Widenfalk, and L. Olson. 2005b. Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury. J. Comp. Neurol. 489(1):1–10.
Liu, X., D.B. McCreery, R.R. Carter, L.A. Bullara, T.G. Yuen, and W.F. Agnew. 1999. Stability of the interface between neural tissue and chronically implanted intracortical microelectrodes. IEEE Trans. Rehab. Eng. 7(3):315–326.
Ludwig, K.A., J.D. Uram, J. Yang, D.C. Martin, and D.R. Kipke. 2006. Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4ethylenedioxythiophene) (PEDOT) film. J. Neural Eng. 3(1):59–70.
Merrill, D.R. and P.A. Tresco. 2005. Impedance characterization of microarray recording electrodes in vitro. IEEE Trans. Biomed. Eng. 52(11):1960–1965.
Mountcastle, V.B., P.W. Davies, and A.L. Berman. 1957. Response properties of neurons of cat's somatic cortex to peripheral stiumuli. J. Neurophysiol. 20(4):374–407.
Musallam, S., M.J. Bak, P.R. Troyk, and R.A. Andersen. 2007. A floating metal microelectrode array for chronic implantation. J. Neurosci. Meth. 160(1):122–127.
Musallam, S., B.D. Corneil, B. Greger, H. Scherberger, and R.A. Andersen. 2004. Cognitive control signals for neural prosthetics. Science305(5681):258–262.
Nagy, J.I. and J.E. Rash. 2000. Connexins and gap junctions of astrocytes and oligodendrocytes in the CNS. Brain Res. Brain Res. Rev. 32(1):29–44.
Nicolelis, M.A., D. Dimitrov, J.M. Carmena, R. Crist, G. Lehew, J.D. Kralik, and S.P. Wise. 2003. Chronic, multisite, multielectrode recordings in macaque monkeys. Proc. Natl. Acad. Sci. USA100(19):11041–11046.
Polikov, V.S., P.A. Tresco, and W.M. Reichert. 2005. Response of brain tissue to chronically implanted neural electrodes. J. Neurosci. Meth. 148(1):1–18.
Rall, W. 1962. Electrophysiology of a dendritic neuron model. Biophys. J. 2(2pt2):145–167.
Rennaker, R.L., S. Street, A.M. Ruyle, and A.M. Sloan. 2005. A comparison of chronic multichannel cortical implantation techniques: manual versus mechanical insertion. J. Neurosci. Meth. 142(2):169–176.
Robinson, F.R. and H.T. Johnson. 1961. Histopatholgical studies of tissue reactions to various metals implanted in cat brains. ASD Technical Report61–397, Wright-Patterson Air Force Base, Ohio, 1–16.
Rousche, P.J. and R.A. Normann. 1998. Chronic recording capability of the Utah intracortical electrode array in cat sensory cortex. J. Neurosci. Meth. 82(1):1–15.
Rousche, P.J., D.S. Pellinen, D.P. Pivin, Jr., J.C. Williams, R.J. Vetter, and D.R. Kipke. 2001. Flexible polyimide-based intracortical electrode arrays with bioactive capability. IEEE Trans. Biomed. Eng. 48(3):361–371.
Santhanam, G., S.I. Ryu, B.M. Yu, A. Afshar, and K.V. Shenoy. 2006. A high-performance brain-computer interface. Nature442(7099):195–198.
Schmidt, E.M. 1980. Single neuron recording from motor cortex as a possible source of signals for control of external devices. Ann. Biomed. Eng. 8(4–6):339–349.
Schmidt, E.M., M.J. Bak, and J.S. McIntosh. 1976. Long-term chronic recording from cortical neurons. Exp. Neurol. 52(3):496–506.
Schmidt, S., K. Horch, and R. Normann. 1993. Biocompatibility of silicon-based electrode arrays implanted in feline cortical tissue. J. Biomed. Mater. Res. 27(11):1393–1399.
Schultz, R.L and T.J. Willey. 1976. The ultrastructure of the sheath around chronically implanted electrodes in brain. J. Neurocytol. 5(6):621–642.
Schwartz, A.B., X.T. Cui, D.J. Weber, and D.W. Moran. 2006. Brain-controlled interfaces:movement restoration with neural prosthetics. Neuron52(1):205–220.
Serruya, M.D., N.G. Hatsopoulos, L. Paninski, M.R. Fellows, and J.P. Donoghue. 2002. Instant neural control of a movement signal. Nature416(6877):141–142.
Seymour, J. and D.R. Kipke. 2006. Ultra-fine structures on neural probes reduce cellular encapsulation. Soc. Neurosci. Annu. Meet. 354:16.
Stensaas, S.S. and L.J. Stensaas. 1978. Histopathological evaluation of materials implanted in the cerebral cortex. Acta Neuropathol. (Berl) 41(2):145–155.
Stensaas, S.S. and L.J. Stensaas. 1976. The reaction of the cerebral cortex to chronically implanted plastic needles, Acta Neuropathol. (Berl) 35(3):187–203.
Subbaroyan, J., D.C. Martin, and D.R. Kipke. 2005. A finite-element model of the mechanical effects of implantable microelectrodes in the cerebral cortex. J. Neural Eng. 2(4):103–113.
Subbaroyan, J., T.D.K. Yoshida, and D.R. Kipke. 2006. Chronic tissue response evoked by variably flexible intracortical polymer implant systems. Atlanta, GA: Society for Neuroscience Abstracts. Sykova, E. 2005. Glia and volume transmission during physiological and pathological states, J. Neural Transm. 112(1):137–147.
Szarowski, D.H., M.D. Andersen, S. Retterer, A.J. Spence, M. Isaacson, H.G. Craighead, J.N. Turner, and W. Shain. 2003. Brain responses to micro-machined silicon devices. Brain Res. 983(1–2):23–35.
Taylor, D.M., S.I. Tillery, and A.B. Schwartz. 2002. Direct cortical control of 3D neuroprosthetic devices. Science296(5574):1829–1832.
Turner, J.N., W. Shain, D.H. Szarowski, M. Andersen, S. Martins, M. Isaacson, and H. Craighead. 1999. Cerebral astrocyte response to micromachined silicon implants. Exp. Neurol. 156(1):33–49.
Wessberg, J., C.R. Stambaugh, J.D. Kralik, P.D. Beck, M. Laubach, J.K. Chapin, J. Kim, S.J. Biggs, M.A. Srinivasan, and M.A. Nicolelis. 2000. Real-time prediction of hand trajectory by ensembles of cortical neurons in primates. Nature408(6810):361–365.
Williams, J.C., R.L. Rennaker, and D.R. Kipke. 1999. Long-term neural recording characteristics of wire microelectrode arrays implanted in cerebral cortex. Brain Res. Brain Res. Protoc. 4(3):303–313.
Yuen, T.G. and W.F. Agnew. 1995. Histological evaluation of polyesterimide-insulated gold wires in brain. Biomaterials16(12):951–956.
Zhong, Y. and R.V. Bellamkonda. 2005. Controlled release of antiinflammatory agent alphaMSH from neural implants. J. Control Rel. 106(3):309–318.
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Tresco, P.A., Gerhardt, G.A. (2008). The Biotic-Abiotic Interface. In: Brain-Computer Interfaces. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8705-9_3
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