Crimean-Congo hemorrhagic fever virus (CCHFV) constitutes a group of viruses of the genus Nairovirus (family Bunyaviridae). Like all members of the Bunyaviridae, the genome of CCHFV is composed of tripartite single-stranded RNA. These segments, designated small (S), medium (M), and large (L), minimally encode the nucleocapsid (N), envelope glycoproteins (Gn and Gc), and RNA-dependent RNA polymerase (RdRp), respectively [38].
Chapter PDF
Similar content being viewed by others
Keywords
- Molecular Epidemiology
- Severe Acute Respiratory Syndrome
- Rift Valley Fever
- Hantavirus Pulmonary Syndrome
- Complete Sequence Data
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Archer AM, Rico-Hesse R (1992) High genetic divergence and recombination in arenaviruses from the Americas. Virology 304:274–281.
Chandler LJ, Hogge G, Endres M, Jacoby DR, Nathanson N, Beaty BJ (1991) Reassortment of La Crosse and Tahyna bunyaviruses in Aedes triseriatus mosquitoes. Virus Res 20:181–191.
Chamberlain J, Cook N, Lloyd G, Mioulet V, Tolley H, Hewson R (2005) Co-evolutionary patterns of variation in small and large RNA segments of Crimean-Congo hemorrhagic fever virus. J Gen Virol 86:3337–3341.
Chare ER, Gould EA, Holmes EC (2003) Phylogenetic analysis reveals a low rate of homologous recombination in negative-sense RNA viruses. J Gen Virol 84:2691–2703.
Chao L (1994) Evolution of genetic exchange in RNA viruses. In: Morse SS (ed.) The Evolutionary Biology of Viruses. Raven Press Pub, New York, pp 233–250.
Chao L (1990) Fitness of RNA virus decreased by Muller's ratchet. Nature 348:454–455.
Chao L (1988) Evolution of sex in RNA viruses. J Theor Biol 133:99–122.
Deyde VM, Khristova ML, Rollin PE, Ksiazek TG, Nichol ST (2006) Crimean-Congo hemorrhagic fever virus genomics and global diversity. J Virol 80:8834–8842.
Drosten C, Minnak D, Emmerich P, Schmitz H, Reinicke T (2002) Crimean-Congo hemorrhagic fever in Kosovo. J Clin Microbiol 40:1122–1123.
Gonzalez-Scarano F, Nathanson N (1996) Bunyaviridae. In: Fields BN, Knipe DM, Howley PM (eds) Virology, 4th edn. Lippincott-Raven Pub, Philadelphia, pp 1473–1504.
Govorkova EA, Rehg JE, Krauss S, Yen HL, Guan Y, Peiris M, Nguyen TD, Hanh TH, Puthavathana P, Long HT, Buranathai C, Lim W, Webster RG, Hoffmann E (2005) Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol 79:2191–2198.
Hewson R, Chamberlain J (2003) (unpublished).
Hewson R, Chamberlain J, Clegg C, Jamil B, Hasan R, Gmyl A, Gmyl L, Smirnova SE, Lukashev A, Karganova G (2004) Crimean-Congo haemorrhagic fever virus: sequence analysis of the small RNA segments from a collection of viruses world wide. Virus Res 102:185–189.
Hewson R, Gmyl A, Gmyl L, Smirnova SE, Karganova G, Jamil B, Hasan R, Chamberlain J, Clegg C (2004) Evidence of segment reassortment in Crimean-Congo haemorrhagic fever virus. J Gen Virol 85:3059–3070.
Henderson WW, Monroe MC, St Jeor SC, Thayer WP, Rowe JE, Peters CJ, Nichol ST (1995) Naturally occurring Sin Nombre virus genetic reassortants. Virology 214:602–610.
Holland J, Spindler K, Horodyski F, Grabau E, Nichol S, VandePol S (1982) Rapid evolution in RNA genomes. Science 215:1577–1585.
Holmes EC (2004) The phylogeography of human viruses. Mol Ecol 13:745–756.
Hoogstraal H (1979) The epidemiology of tick borne Crimean-Congo hemorrhagic fever in Asia, Europe and Africa. J Med Entomol 15:307–417.
Hu WS, Temin HM (1990) Retroviral recombination and reverse transcription. Science 250:1227–1233.
Iturriza-Gomara M, Isherwood B, Desselberger U, Gray J (2001) Reassortment in vivo: driving force for diversity of human rotavirus strains isolated in the United Kingdom between 1995 and 1999. J Virol 75:3696–3705.
Jenkins GM, Rambaut A, Pybus OG, Holmes EC (2002) Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis. J Mol Evol 54:152–161.
Johnson KM, Morse S (1993) Emerging viruses in context: an overview of viral hemorrhagic fevers. In: Morse S. (ed.) Emerging Viruses. Oxford University Press, Oxford, pp 46–57.
Klempa B, Schmidt HA, Ulrich R, Kaluz S, Labuda M, Meisel H, Hjelle B, Kruger DH (2003) Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A. flavicollis in nature. J Virol 77:804–809.
Lai MMC (1992) RNA recombination in animal and plant viruses. Microbiol Rev 56:61–79.
Li KS, Xu KM, Peiris JS, Poon LL, Yu KZ, Yuen KY, Shortridge KF, Webster RG, Guan Y (2003) Characterisation of H9 subtype influenza viruses from the ducks of southern China: a candidate for the next influenza pandemic in humans? J Virol 77:6988–6994.
Lukashev A (2005) Evidence for recombination in Crimean-Congo hemorrhagic fever virus. J Gen Virol 86:2333–2338.
Muller HJ (1964) The relation of recombination to mutational advance. Mutant Res 1:2–9.
Nuttall PA, Jones LD, Davies CR (1991) Advances in disease vectors research: the role of arthropod vectors in arbovirus evolution. Adv Dis Vector Res 8:16–45.
Petrova ID, Seregin SV, Petrov VS, Veshemirskii OI, Kuzina II, Lvov DK, Smokhvalov EI, Tyunnikov GI, Gutorov VV, Yashina LN, Netesov SV (2003) Genetic characteristics of the S segments of RNA from two strains of the Crimean-Congo hemorrhagic fever virus isolate in the south of Russia and in Uzbekistan (in Russian) Vopr Virusol 48:8–11.
Pierce CM, Balasuriya UB, MacLachlan NJ (1998) Phylogenetic analysis of the S10 gene of field and laboratory strains of bluetongue virus from the United States. Virus Res 55:15–27.
Pressing J, Reanney DC (1984) Divided genomes and intrinsic noise. J Mol Evol 20:135–146.
Pringle CR, Parry JE (1982) Measurement of surface antigen by specific bacterial adherence and scanning electron microscopy (SABA/SEM) in cells infected by vesiculovirus ts mutants. J Gen Virol 59:207–211.
Pringle CR, Lees JF, Clark W, Elliot R (1984) Genome subunit reassortment among bunyaviruses analysed by dot hybridization using molecularly cloned complementary DNA probes. Virology 135:244–256.
Posada D, Crandall KA, Holmes EC (2002) Recombination in evolutionary genomics. Ann Rev Genet 36:75–97.
Qiu WP, Geske SM, Hickey CM, Moyer JW (1998) Tomato spotted wilt Tospovirus genome reassortment and genome segment-specific adaptation. Virology 244:186–194.
Rodriguez LL, Maupin GO, Ksiazek TG, Rollin PE, Khan AS, Schwarz TF, Lofts RS, Smith JF, Noor AM, Peters CJ, Nichol ST (1997) Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates. Am J Trop Med Hyg 57:512–518.
Rodriguez LL, Owens JH, Peters CJ, Nichol ST (1998) Genetic reassortment among viruses causing hantavirus pulmonary syndrome. Virology 242:99–106.
Schmaljohn CS, Hooper JW (2001) Bunyaviridae. In: Fields BN, Knipe DM, Howley PM (eds) Virology, 4th edn. Lippincott-Raven Pub, Philadelphia, pp 1581–1602.
Sibold C, Meisel H, Kruger DH, Labuda M, Lysy J, Kozuch O, Percoch M, Vaheri A, Plyusnin A (1999) Recombination in Tula hantavirus evolution: analysis of genetic lineages from Slovakia. J Virol 73:667–675.
Turell MJ, Saluzzo JF, Tammariello RF, Smith JF (1990) Generation and transmission of Rift Valley fever viral reassortants by the mosquito Culex pipiens. J Gen Virol 71:2307–2312.
To KF, Tong JH, Chan PK, Au FW, Chim SS, Chan KC, Cheung JL, Liu EY, Tse GM, Lo AW, Lo YM, Ng HK (2004) Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal cases. J Pathol 202:157–163.
Uruidi V, Bishop DH (1992) Non-random reassortment between the tripartite RNA genomes of La Crosse and snowshoe hare viruses. J Gen Virol 73:2255–2265.
Watts DM, Kziasek TG, Linthicum KJ, Hoogstraal H (1988) Crimean-Congo hemorrhagic fever. In: Monath TP (ed.) The Arboviruses: Epidemiology and Ecology. vol 2. CRC Press, Boca Raton, FL, pp 177–260.
Weaver SC (2006) Evolutionary influences in arboviral disease. Curr Top Microbiol Immunol 299:285–314.
Whitehouse CA (2004) Crimean-Congo hemorrhagic fever. Antiviral Res 64:145–160.
Worobey M, Holmes EC (1999) Evolutionary aspects of recombination in RNA viruses. J Gen Virol 80:2535–2543.
WHO (2004) Report of the WHO/FAO/OIE consultation on emerging zoonotic diseases. http://whqlibdoc.who.int/hq/2004/WHO_CDS_CPE_ZFK_2004.9.pdf.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer
About this chapter
Cite this chapter
Hewson, R. (2007). Molecular Epidemiology, Genomics, and Phylogeny of Crimean-Congo Hemorrhagic Fever Virus. In: Ergonul, O., Whitehouse, C.A. (eds) Crimean-Congo Hemorrhagic Fever. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6106-6_5
Download citation
DOI: https://doi.org/10.1007/978-1-4020-6106-6_5
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-6105-9
Online ISBN: 978-1-4020-6106-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)