Abstract
Acute ethanol administration causes extensive apoptosis throughout the nervous system. We studied the protective effect of taurine on alcohol-induced apoptosis in the cerebellum of developing mice. Taurine rescued a part of immature neurons by markedly reducing caspase-3 immunoreactivity and the number of TUNEL-positive cells in most cerebellar lobules.
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Keywords
- Fetal Alcohol Spectrum Disorder
- Fetal Alcohol Syndrome
- Ethanol Administration
- Cerebellar Lobule
- Taurine Treatment
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Taranukhin, A.G., Taranukhina, E.Y., Djatchkova, I.M., Saransaari, P., Pelto-Huikko, M., Oja, S.S. (2009). Taurine Protects Immature Cerebellar Granullar Neurons against Acute Alcohol Administration. In: Azuma, J., Schaffer, S.W., Ito, T. (eds) Taurine 7. Advances in Experimental Medicine and Biology, vol 643. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75681-3_16
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DOI: https://doi.org/10.1007/978-0-387-75681-3_16
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