Skip to main content
SpringerLink
Log in

Novel Bioabsorbable Antibiotic Releasing Bone Fracture Fixation Implants

  • Conference paper
Biomaterials

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 553))

Abstract

Bone infection is a serious complication that may follow any surgery or trauma. The risk of infection is especially high in immunocompromised patients such as diabetics, aged and those on immunosuppressive drugs1–3. Around 50% to 70% of patients with open (compound) fractures have bacterial contamination of their wounds and potential risk of a bone infection1,4. In 2001 the estimated number of fracture fixation deviceassociated infections was 100 000 — 200 0005.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Mader, J.T., and Calhoun, J.H., 2003, Staging and Staging Application in Osteomyelitis, In Musculosceletal Infections (J.H. Calhoun and J.T. Mader, eds.), Marcel Dekker, Inc., New York, pp.63–77.

    Google Scholar 

  2. Wang, J., Calhoun, J.H., Mader, J.T., and Lazzarini, L., 2003, Musculoskeletal Infection in Systemically and Locally Immunocompromised Hosts. In Musculosceletal Infections (J.H. Calhoun and J.T. Mader, eds.), Marcel Dekker, Inc., New York, pp.79–114.

    Google Scholar 

  3. Lazzarini, L., Mader, J.T., and Calhoun, H., 2003, Diabetic Foot Infection. In Musculoskeletal Infections (J.H. Calhoun and J.T. Mader, eds.), Marcel Dekker, Inc., New York, pp.325–339.

    Google Scholar 

  4. Patzakis, J., Zalavras, C.G., and Holtom, P.D., 2003, Open Fractures, Current Concepts of Management. In Musculosceletal Infections (J.H. Calhoun and J.T. Mader, eds.), Marcel Dekker, Inc., New York, pp.131–147.

    Google Scholar 

  5. Darouiche, R.O., 2001, Review. Device-associated infections: a macroproblem that starts with microadherence, Clin. Infect. Dis. 33(9):1567–1572.

    Article  Google Scholar 

  6. Mader, J.T., Landon, G.C., and Calhoun, J. 1993, Antimicrobial Treatment of Osteomyelitis, Clinical Orthopaedics and Related Research 295: 87–95.

    Google Scholar 

  7. Garvin, K.L., Miyano, J.A., Robinson, D., Giger D., Novak, J., and Radio, S., 1994, Polylactide/Polyglycolide Antibiotic Implants in the Treatment of Osteomyelitis, A Canine Model, The Journal of Bone and Joint Surgery 76-A, 10:1500–1506.

    Google Scholar 

  8. Stengel, D., Bauwens, K., Sehouli, J., Ekkernkamp, A., and Porzsolt, F., 2001, Review. Systemic rewiev and meta-analysis of antibiotic therapy for bone and joint infections, Lancet Infectious Diseases1: 175–188.

    Article  Google Scholar 

  9. Wiesel, B.B., and Esterhai, J.L., Jr., 2003, Prophylaxic of Musculoskeletal Infection, In Musculoskeletal Infections (J.H. Calhoun and J.T. Mader, eds.), Marcel Dekker, Inc., New York, pp.115–129.

    Google Scholar 

  10. Laurencin, C.T., Gerhart, T., Witschger, P., Satcher, R., Domb, A., Rosenberg, A.E., Hanff, P., Edsberg, L., Hayes, W., and Langer, R., 1993, Bioerodible Polyanhydrides for Antibiotic Drug Delivery: In Vivo Osteomyelitis Treatment in a Rat Model System, Journal of Orthopaedic Research 11:256–262.

    Article  Google Scholar 

  11. Wu, X.S., 1996, Controlled Drug Release Systems (Part I), Technomic Publishing Co., Inc., pp. 1–149.

    Google Scholar 

  12. Graham, N.B., and Wood, D.A., 1984, Polymeric inserts and implants for the controlled release of drugs, In Macromolecular Biomaterials (G.W. Hastings, and P. Ducheyne, eds.), CRC Press, Inc., Boca Raton, pp.181–208.

    Google Scholar 

  13. Li, V.H.K., Robinson, J.R., and Lee, V.H.L., 1987, Influence of Drug Properties and Routes of Drug Administration on the Design of Sustained and Controlled Release Systems. In Controlled Drug Delivery, Fundamentals and Applications, (J.R. Robinson and V.H.L Lee, eds.), Marcel Dekker, Inc., New York, pp.3–94.

    Google Scholar 

  14. Kanellakopoulou, K., and Giamarellos-Bourboulis, E.J., 2000, Carrier Systems for the Local Delivery of Antibiotics in Bone Infections, Drugs 59(6):1223–1232

    Article  Google Scholar 

  15. Nijhof, M.W., Dhert, J.A., Fleer, A., Vogely, H.C., and Verbout, A.J., 2000, Prophylaxis of implant-related staphylococcal infections using tobramycin-containing bone cement, Journal of Biomedical Materials Research 52(4):754–761.

    Article  Google Scholar 

  16. Stephens, D., Li, L., Robinson, D., Chen, S., Chang, H-C., Liu, R.M., Tian, Y., Ginsburg, E.J., Gao, X., and Stultz, T., 2000, Investigation of the in vitro release of gentamicin from a polyanhydride matrix, Journal of Controlled Release 63:305–317.

    Article  Google Scholar 

  17. Lew, D.P., and Waldvogel, F.A., 1995, Quinolones and Osteomyelitis: State-of-the-Art, Drugs 49(2):100–111.

    Article  Google Scholar 

  18. Andreopoulos, A.G., Korakis, T., Dounis, E., Anastasiadis, A., Tzivelekis, P., and Kanellakopoulou, K., 1996, In vitro Release of New Quinolones from Biodegradable Systems: A Comparative Study, Journal of Biomaterials Applications 10:338–347.

    Google Scholar 

  19. Dounis, E., Korakis, T., Anastasiadis, A., Kanellakopoulou, K., Andreopoulos, A., and Giamarellou, H., 1996, Sustained release of fleroxacin in vitro from lactic acid polymer, Hospital for Joint Diseases 55(1):16–19.

    Google Scholar 

  20. Burd, T.A., Anglen, J.O., Lowry, K.J., Hendricks, K.J., and Day, D., 2001, In Vitro Elution of Tobramycin From Bioabsorbable Polycarbolactone Beads, Journal of Orthopaedic Trauma 15(6):424–428.

    Article  Google Scholar 

  21. Lambert, H.P., and O’Grady, F.W., 1992, Quinolones, In Antibiotic and Chemotherapy, pp.245–262.

    Google Scholar 

  22. Christian, J.S., 1996, The Quinolone Antibiotics, Prim Care Update Ob/GGGyns 3:87–92.

    Article  Google Scholar 

  23. Miclau, T., Edin, M.L., Lester, G.E., Lindsey, R.W., and Dahners, L.E., 1998, Effect ot Ciprofloxacin on the Proliferation of Osteoblast-like MG-63 Human Osteosarcoma Cells In Vitro, Journal of Orthopaedic Research 16:509–512.

    Article  Google Scholar 

  24. Holtom, P.D., Pavkovic, S.A., Bravos, P.D., Patzakis, M.J., Shepherd, L.E., and Frenkel, B., 2000, Inhibitory Effects of the Quinolone Antibiotics Trovafloxacin, Ciprofloxacin, and Levofloxacin on Osteoblastic Cells In Vitro, Journal of Orthopaedic Research 18:721–727.

    Article  Google Scholar 

  25. Törmälä, P., and Rokkanen, P., 2001, Review. Bioabsorbable Implants in the fixation of fractures, Annales Chirurgiae et Gynaecologiae 90:81–85.

    Google Scholar 

  26. Törmälä, P., Pohjonen, T., and Rokkanen, P., 1998, Bioabsorbable polymers: materials technology and surgical applications, Proc Instn Mech Engrs 212(H):101–111.

    Google Scholar 

  27. Suuronen, R., Kallela, I., and Lindqvist, C., 2000, Invited Review. Bioabsorbable Plates and Screws: Current State of the Art in Facial Fracture Repair, Journal of CranioMaxillofacial Trauma 6(1):19–27.

    Google Scholar 

  28. ASTM B 769–94, 2000, Standard Test Method for Shear Testing of Aluminum Alloys

    Google Scholar 

  29. ASTM D 790–00, 2000, Standard Test Method for Flexural Properties of Unreinforced and Reinforced Plastics and Electrical Insulating Materials

    Google Scholar 

  30. DIN 53452, 1977, Testing of plastics; bending test

    Google Scholar 

  31. ASTM F 117–79, 1985, Standard Test Method for Driving Torque of Self-Tapping Medical Bone Screws

    Google Scholar 

  32. Claes, L., Rehm, K., and Hutmacher, D., 1992, The Development of a New Degradable Pin for the Refixation of Bone Fragments, Fourth World Biomaterials Congress, April 24–28, Berlin, 205.

    Google Scholar 

  33. An, Y.H., Woolf, S.K., and Friedman, R.J., 2000, Pre-clinical in vivo evaluation of orthopaedic bioabsorbable devices, Biomaterials 21:2635–2652

    Article  Google Scholar 

  34. Veiranto, M., Suokas, E., and Törmälä, P., 2002, In vitro mechanical and drug release properties of bioabsorbable ciprofloxacin containing and neat self-reinforced P(L/DL)LA 70/30 fixation screws, Journal of Materials Science: Materials in Medicine 13:1259–1263.

    Article  Google Scholar 

  35. Tiainen, J., Veiranto, M., Suokas, E., Törmälä, P., Waris, T., Ninkovic, M., and Ashammakhi, N., 2002, Bioabsorbable ciprofloxacin-containing and plain selfreinforced polylactide-polyglycolide 80/20 screws: pullout strength properties in human cadaver parietal bones, J Craniofac Surg 13(3):427–433.

    Article  Google Scholar 

  36. Leinonen, S., Suokas, E., Veiranto, M., Törmälä, P., Waris, T., and Ashammakhi, N., 2002, Holding Power of Bioabsorbable Ciprofloxacin-Containing Self-Reinforced PolyL/DL-lactide 70/30 Bioactive Glass 13 Miniscrews in Human Cadaver Bone, J Craniofac Surg 13(2):212–218.

    Article  Google Scholar 

  37. Veiranto, M., Suokas, E., and Törmälä, P., 2002, Controlled Release of Ciprofloxacin from Fixation Screws Based on Poly(lactide-co-glycolide), Society for Biomaterials 28th Annual Meeting, April 24–27, Tampa, Florida, USA, 637.

    Google Scholar 

  38. Niemelä, S-M., Ikäheimo, I., Koskela, M., Syrjälä, H., Veiranto, M., Suokas, E., Waris, T., Törmälä, P., and Ashammakhi, N., 2003, Multifunctional Bioabsorbable Ciprofloxacin-Releasing Devices Inhibit Bacterial Attachment and Biofilm Formation. Biofilms in Medicine, October 17–19, Elsinor, Denmark.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biomaterials, Tampere University of Technology, Tampere, Finland

    Minna Veiranto, Nureddin Ashammakhi & Pertti Törmälä

  2. Linvatec Biomaterials Ltd., Tampere, Finland

    Esa Suokas

Authors
  1. Minna Veiranto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Esa Suokas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nureddin Ashammakhi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pertti Törmälä
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Biomaterials Research Labs, Middle East Technical University, Ankara, Turkey

    Nesrin Hasirci  & Vasif Hasirci  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Science+Business Media New York

About this paper

Cite this paper

Veiranto, M., Suokas, E., Ashammakhi, N., Törmälä, P. (2004). Novel Bioabsorbable Antibiotic Releasing Bone Fracture Fixation Implants. In: Hasirci, N., Hasirci, V. (eds) Biomaterials. Advances in Experimental Medicine and Biology, vol 553. Springer, Boston, MA. https://doi.org/10.1007/978-0-306-48584-8_15

Download citation

  • DOI: https://doi.org/10.1007/978-0-306-48584-8_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0988-9

  • Online ISBN: 978-0-306-48584-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation