Summary
Ophthalmic imaging technology has revolutionized fundus examination. FAF imaging represents one of various novel tools and provides information over and above fundus photography, fluorescence angiography and optical coherence tomography. This noninvasive diagnostic tool visualizes age- and disease-related metabolic changes of the retinal pigment epithelium. The autofluorescence signal mainly derives from dominant fluorophores in lipofuscin granules of the RPE. Lipofuscin accumulation represents a common downstream pathogenetic pathway in many retinal and macular disease entities.Thus FAF imaging contributes significantly to our understanding of the pathophysiology and treatment of various retinal diseases.
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Keywords
- Retinal Pigment Epithelial Cell
- Geographic Atrophy
- Macular Pigment
- Lipofuscin Granule
- Fundus Autofluorescence
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Bindewald, A., Roth, F., Schmitz-Valckenberg, S., Scholl, H.P., Holz, F.G. (2005). Fundus Autofluorescence Imaging. In: Holz, F.G., Spaide, R.F. (eds) Medical Retina. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27272-0_2
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