Abstract
The chemical structure of poly(ADP-ribose) suggests not only that its modification of acceptor proteins should modify the structure and function of the acceptor proteins, but also that the poly(ADP-ribose) molecule itself should possess an intrinsic structural information that can alter cellular function(s).
The localization of PARP-1 to the centrosome clearly shows that its function is not only confined to the nucleus, but plays a role also in the cytoplasm. Thus poly(ADP-ribosyl)ation should be considered an important regulatory mechanism not only in the nucleus, but in the cell at large. In this context, the interaction between nuclear and cytoplasmic events through the poly(ADP-ribosyl)ation reaction is an intriguing possibility.
Understanding poly(ADP-ribose) metabolism has an important impact for unraveling fundamental biological mechanisms ranging from chromosomal instability in cancer, the morphogenesis of the tissues and the maintenance of neuronal cell functions.
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Keywords
- Amyotrophic Lateral Sclerosis
- Nuclear Pore Complex
- Mouse Embryo Fibroblast
- Neuronal Integrity
- Centrosomal Protein
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Miwa, M., Kanai, M., Uchida, M., Uchida, K., Hanai, S. (2006). Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity. In: Poly(ADP-Ribosyl)ation. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-36005-0_5
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DOI: https://doi.org/10.1007/0-387-36005-0_5
Publisher Name: Springer, Boston, MA
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