9.7 Conclusion
By combining MEA electrophysiology with long-term time-lapse imaging, it is possible to make correlations between changes in network function and changes in neuronal morphology. By re-embodying dissociated cultured networks, network function can be mapped onto behavior, and in vitro research can now make use of a new kind of behavioral studies that include detailed (submicron) imaging not possible in vivo. By closing the sensory-motor loop around MEA cultures, they are more likely to shed light on the mechanisms of learning, memory, and information processing in animals.
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Potter, S.M., Wagenaar, D.A., DeMarse, T.B. (2006). Closing the Loop: Stimulation Feedback Systems for Embodied MEA Cultures. In: Taketani, M., Baudry, M. (eds) Advances in Network Electrophysiology. Springer, Boston, MA . https://doi.org/10.1007/0-387-25858-2_9
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