Overview
- Presents impact of the integrative structural biology
- Provides Future perspective of the hybrid methods and their applications
- Covers detailed description of experimental and computational methods in the hybrid methods
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1105)
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About this book
This book presents a new emerging concept of "Integrative Structural Biology". It covers current trends of the molecular and cellular structural biology, providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understand the hybrid methods. This book discusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion of the data validation and archive, which are big problems in this filed along with the progress of this field. The researchers in biology will be interested inthis book as a guide book for learning the current structure biology, but also those in structure biology may use this book as a comprehensive reference to cover broad topics.
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Table of contents (16 chapters)
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Introduction and Historical Background
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New Experimental Tools Enabling Hybrid Methods
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New Computational Tools Enabling Hybrid Methods
Editors and Affiliations
About the editors
Haruki Nakamura
Osaka University, Institute for Protein Research, Japan
Gerard J. Kleywegt
European Bioinformat Inst, Prot Data Bank Europe, England
Stephen K. Burley
Rutgers State University, Center for Integrative Proteomics Research, USA
John L. Markley
University of Wisconsin, Biochemistry Department, Natl Magnet Resonance Facil Madison, USA
Bibliographic Information
Book Title: Integrative Structural Biology with Hybrid Methods
Editors: Haruki Nakamura, Gerard Kleywegt, Stephen K. Burley, John L. Markley
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-13-2200-6
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2018
Hardcover ISBN: 978-981-13-2199-3Published: 25 January 2019
eBook ISBN: 978-981-13-2200-6Published: 08 January 2019
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VI, 272
Number of Illustrations: 17 b/w illustrations, 44 illustrations in colour
Topics: Protein Structure, Cell Biology