Overview
- Authors:
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R. A. Chalmers
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M.R.C. Clinical Research Centre, Harrow, UK
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A. M. Lawson
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M.R.C. Clinical Research Centre, Harrow, UK
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About this book
The writing of this book was prompted by the need for a comprehensive of current data on organic acids suitable for both newcomers and collection established researchers in this field. The only previous text of the kind was the excellent review by Nordmann and Nordmann (1961), and at that time the main method of analysis was paper chromatography with liquid chromatography being used in a limited way. Only three diseases in which organic acids accumulate were known (primary hyperoxaluria, phenylketonuria and alcaptonuria). Since then, with the development of gas chromatography and mass spectrometry, and the further development ofliquid chromatography, knowledge concerning the nature of the organic acids in physiological fluids has been greatly extended. At the same time, the number of organic acidurias has increased dramatically, there being now some 40-50 known diseases of this type. During the past 15 years or so, there have been several reviews, dealing with either specific diseases or groups of diseases (Gompertz, 1972, 1974; Tanaka, 1975), or presenting the proceedings of symposia (Stern and Toothill, 1972) or workshops (Marner et al. , 1974). This present text deals comprehensively and in detail with the organic acids in human physiological fluids in health and in disease states, and is particularly concerned with the methods necessary for their separation, determination and indentification.
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Table of contents (17 chapters)
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Front Matter
Pages i-xiii
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Introduction
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- R. A. Chalmers, A. M. Lawson
Pages 1-8
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Methods
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- R. A. Chalmers, A. M. Lawson
Pages 11-26
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- R. A. Chalmers, A. M. Lawson
Pages 27-45
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- R. A. Chalmers, A. M. Lawson
Pages 46-82
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- R. A. Chalmers, A. M. Lawson
Pages 83-127
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- R. A. Chalmers, A. M. Lawson
Pages 128-135
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Back Matter
Pages 136-160
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Organic acids in physiological fluids from normal subjects
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Front Matter
Pages 161-162
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- R. A. Chalmers, A. M. Lawson
Pages 163-195
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- R. A. Chalmers, A. M. Lawson
Pages 196-203
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Back Matter
Pages 204-208
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Organic acids in human metabolic diseases (the organic acidurias)
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Front Matter
Pages 209-209
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- R. A. Chalmers, A. M. Lawson
Pages 211-238
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- R. A. Chalmers, A. M. Lawson
Pages 239-295
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- R. A. Chalmers, A. M. Lawson
Pages 296-331
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- R. A. Chalmers, A. M. Lawson
Pages 332-337
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- R. A. Chalmers, A. M. Lawson
Pages 338-349
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- R. A. Chalmers, A. M. Lawson
Pages 350-382