Overview
- Broadens the reader’s understanding of the challenges entailed by the threat of an antibiotic crisis
- Will stimulate future work on urgently needed antibacterial drug discovery
- Covers both basic and applied aspects
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 398)
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About this book
This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.
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Keywords
Table of contents (17 chapters)
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Front Matter
Editors and Affiliations
About the editors
Prof. Dr. Marc Stadler and Prof. Dr. Petra DerschHelmholtz Centre for Infection Research, Braunschweig, Germany
Bibliographic Information
Book Title: How to Overcome the Antibiotic Crisis
Book Subtitle: Facts, Challenges, Technologies and Future Perspectives
Editors: Marc Stadler, Petra Dersch
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-319-49284-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016
Hardcover ISBN: 978-3-319-49282-7Published: 02 January 2017
Softcover ISBN: 978-3-319-84121-2Published: 07 July 2018
eBook ISBN: 978-3-319-49284-1Published: 21 December 2016
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: XII, 496
Topics: Medical Microbiology, Infectious Diseases, Bacteriology, Pharmacology/Toxicology, Medicinal Chemistry, Veterinary Medicine/Veterinary Science