Vascular Ion Channels in Physiology and Disease
Overview
- Editors:
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Irena Levitan, PhD
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University of Illinois at Chicago, Chicago, USA
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Alex M. Dopico, MD, PhD
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The University of Tennessee, Memphis, USA
- Presents the studies undertaken in the last decade to elucidate the roles of ion channels in different vascular diseases
- Focuses on the roles of ion channels in vascular tissues under normal and pathological condition
- Written by experts in the field
- Includes supplementary material: sn.pub/extras
About this book
Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions.
Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the firstcomprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.
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Article
Open access
17 January 2017
Table of contents (19 chapters)
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Front Matter
Pages i-xvii
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Ion Channel Regulation of Vascular Tone and Blood Flow. Changes with Hypertension: Endothelial Cells
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- Kwong Tai Cheng, Avia Rosenhouse-Dantsker, Asrar B. Malik
Pages 37-62
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- David W. Busija, Ibolya Rutkai, Prasad V. Katakam
Pages 63-78
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- Erik J. Behringer, Steven S. Segal
Pages 79-99
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- Ralf Köhler, Aida Olivan-Viguera
Pages 101-127
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Ion Channel Regulation of Vascular Tone and Blood Flow. Changes with Hypertension: Smooth Muscle Cell
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Front Matter
Pages 129-129
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- Michael A. Hill, Yan Yang, Zahra Nourian, Barry D. Kyle, Kwangseok Hong, Andrew P. Braun
Pages 131-152
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- M. Dennis Leo, Jonathan H. Jaggar
Pages 153-168
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- Anup K. Srivastava, Lee Ann MacMillan-Crow, Sung W. Rhee, Nancy J. Rusch
Pages 169-190
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- Bharath K. Mani, Lyubov I. Brueggemann, Sarkis Morales-Vidal, Christopher M. Loftus, Kenneth L. Byron
Pages 191-214
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Ion Channels in the Regulation of Cell Proliferation, Remodeling, Hypertrophy and Angiogenesis
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Front Matter
Pages 231-231
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- John G. McCarron, Susan Chalmers, Calum Wilson, Mairi E. Sandison
Pages 233-254Open Access
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- Holly C. Cappelli, Roslin J. Thoppil, Ravi K. Adapala, J. Gary Meszaros, Sailaja Paruchuri, Charles K. Thodeti
Pages 255-273
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- David J. Beech, Jing Li, Lynn McKeown, Hollie L. Appleby
Pages 275-294
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- Ramon J. Ayon, Haiyang Tang, Ruby A. Fernandez, Ayako Makino, Jason X.-J. Yuan
Pages 295-324
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Ion Channel Regulation by Lipids and Channel Modifications in Metabolic Disease
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Front Matter
Pages 325-325
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- Irena Levitan, Sang Joon Ahn, Ibra Fancher, Avia Rosenhouse-Dantsker
Pages 327-347
Editors and Affiliations
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University of Illinois at Chicago, Chicago, USA
Irena Levitan, PhD
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The University of Tennessee, Memphis, USA
Alex M. Dopico, MD, PhD
About the editors
Alex Dopico, PhD, MD, is Chair of Pharmacology and Distinguished Professor at the University of Tennessee Health Science Center, Memphis, Tennessee. His research interest focuses on the molecular interactions between small amphiphilic ligands, such as alcohol, and oligomeric ion channel proteins in excitable tissues, with a particular focus on cerebral artery smooth muscle. Emphasis is put on determining site(s) of action and ion channel gating mechanisms targeted by the amphiphiles, role of membrane lipid microenvironment in regulating ligand-ion channel interaction, and consequences of such interaction on tissue and organ function. Dr. Dopico currently holds a Merit Award from NIAAA, and also served as editor of the book Methods in Membrane Lipids published by Humana in 2007.
Irena Levitan, PhD, is a Professor of Medicine and Adjunct Professor of Pharmacology and Bioengineering at the University of Illinois at Chicago. Her currentresearch interests focus on cholesterol regulation of ion channels and cellular biomechanics. She was named a Guyton Distinguished Lecturer by the Association of Chairs of Departments of Physiology for her quantitative and biophysical work on cholesterol modulation of ion channels and how this can affect integrated organ function. She also served as editor of the book Cholesterol Regulation of Ion Channels and Receptors, published by Wiley in 2012.