Overview
- Reviews up-to-date knowledge of chromosomal instability in cancer
- Examines strategies to harness this information for the better treatment of cancer patients
- Written by acknowledged experts in the field
- Includes supplementary material: sn.pub/extras
Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 200)
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About this book
This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
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Table of contents (9 chapters)
Editors and Affiliations
Bibliographic Information
Book Title: Chromosomal Instability in Cancer Cells
Editors: B. Michael Ghadimi, Thomas Ried
Series Title: Recent Results in Cancer Research
DOI: https://doi.org/10.1007/978-3-319-20291-4
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-20290-7Published: 25 September 2015
Softcover ISBN: 978-3-319-34962-6Published: 22 October 2016
eBook ISBN: 978-3-319-20291-4Published: 16 September 2015
Series ISSN: 0080-0015
Series E-ISSN: 2197-6767
Edition Number: 1
Number of Pages: VII, 224
Number of Illustrations: 39 illustrations in colour
Topics: Oncology, Cancer Research, Human Genetics