Overview
- Provides state-of-the-art review on the important roles of SH domains
- Gives outlook on future applications in stem cell therapy and biomaterials
- Written by international experts from the field
- Includes supplementary material: sn.pub/extras
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About this book
This book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling. Their involvement in various cellular processes such as migration, invasiveness, actin reorganization, shaping spines, determination of the morphology assembly of fibrils, and mechanotransduction makes these molecules attractive drug targets. Substrates, inhibitors and activators of PTKs present a wide variety of therapeutic agents in the context of delivering treatments for numerous pathologies. The new emerging field of stem cell therapies and design of biomaterials for treatments relies on the directed regulation of stem cell growth, differentiation and morphology, as well as the production of biomimetic scaffolds that respond to programmed signals. Advances in deciphering the mechanisms of action of these important molecules will lead to the implementation and success of their vital applications.
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Keywords
Table of contents (11 chapters)
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Front Matter
Editors and Affiliations
Bibliographic Information
Book Title: SH Domains
Book Subtitle: Structure, Mechanisms and Applications
Editors: Natalya Kurochkina
DOI: https://doi.org/10.1007/978-3-319-20098-9
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-20097-2Published: 27 July 2015
Softcover ISBN: 978-3-319-37252-5Published: 15 October 2016
eBook ISBN: 978-3-319-20098-9Published: 17 July 2015
Edition Number: 1
Number of Pages: VIII, 253
Number of Illustrations: 22 b/w illustrations, 30 illustrations in colour
Topics: Protein Science, Protein Structure, Protein-Ligand Interactions, Cell Biology