Overview
- A recently discovered biological entity attracting growing interest from academics worldwide
- Plays key roles in normal physiological processes whilst aberrant biosynthesis can lead, or contribute to, disease states
- Growing impact within the pharmaceutical interest in drugs which manipulate its synthesis or activity
- Includes supplementary material: sn.pub/extras
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 230)
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About this book
This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.
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Keywords
Table of contents (18 chapters)
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Front Matter
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Biochemistry, Molecular Biology and Chemistry
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Front Matter
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Molecular Mechanisms of Action
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Front Matter
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Cardiovascular and Urogenital Systems
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Front Matter
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Inflammation and Inflammatory Disease
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Front Matter
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H2S and the Nervous System
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Front Matter
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H2S, Angiogenesis and Cancer
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Front Matter
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Editors and Affiliations
Bibliographic Information
Book Title: Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide
Editors: Philip K. Moore, Matt Whiteman
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-319-18144-8
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015
Hardcover ISBN: 978-3-319-18143-1Published: 21 July 2015
Softcover ISBN: 978-3-319-35909-0Published: 15 October 2016
eBook ISBN: 978-3-319-18144-8Published: 10 July 2015
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: VI, 395
Number of Illustrations: 145 b/w illustrations, 27 illustrations in colour
Topics: Pharmacology/Toxicology, Human Physiology, Neurosciences, Medical Biochemistry, Medicinal Chemistry