Overview
- Illustrates key transcriptional control mechanisms in immune cells
- Provides insight into the transcriptional regulatory circuits underlying innate and adaptive immunity
- Richly illustrated
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 381)
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About this book
Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during the differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.
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Table of contents (10 chapters)
Editors and Affiliations
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Bibliographic Information
Book Title: Transcriptional Control of Lineage Differentiation in Immune Cells
Editors: Wilfried Ellmeier, Ichiro Taniuchi
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-319-07395-8
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2014
Hardcover ISBN: 978-3-319-07394-1Published: 16 September 2014
Softcover ISBN: 978-3-319-37651-6Published: 23 August 2016
eBook ISBN: 978-3-319-07395-8Published: 02 September 2014
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VIII, 331
Topics: Immunology