Overview
- Editors:
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Christopher B. Fox
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Infectious Disease Research Institute, Seattle, USA
- Includes cutting-edge methods and protocols in the field of vaccine adjuvant research
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
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About this book
This collection seeks to elucidate the practical methods necessary for successful adjuvant development, with a particular focus on the synthesis, formulation, manufacturing, and characterization aspects involved. Beginning with an overview and a case study, the book then delves into in silico design, chemical synthesis, biosynthesis, and/or purification from natural raw materials of specific adjuvant molecules, adjuvant formulation approaches, the analytical characterization of adjuvant formulations and adjuvant-containing vaccines, as well as the biological characterization of vaccine adjuvant activity, including in vitro and in vivo approaches, to measure innate and adaptive immune responses. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Practical and authoritative, Vaccine Adjuvants: Methods and Protocols aims to facilitate vaccine adjuvant product development efforts, making them more accessible, manufacturable, and better characterized.
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Article
Open access
10 October 2018
Table of contents (26 protocols)
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- Ruchi R. Shah, Kimberly J. Hassett, Luis A. Brito
Pages 1-13
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- Mallesh Beesu, Hari Prasad Kokatla, Sunil A. David
Pages 29-44
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- Alberto Fernández-Tejada, William E. Walkowicz, Derek S. Tan, David Y. Gin
Pages 45-71
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- Livia Brunner, Christophe Barnier-Quer, Nicolas Collin
Pages 73-86
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- Anna C. A. Yendo, Fernanda de Costa, Carla Kauffmann, Juliane D. Fleck, Grace Gosmann, Arthur G. Fett-Neto
Pages 87-93
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- Martin Valachovič, Ivan Hapala
Pages 95-106
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- Matthew N. Davies, Helene Pere, Iris Bosschem, Freddy Haesebrouck, Bram Flahou, Eric Tartour et al.
Pages 107-125
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- Yvonne Perrie, Elisabeth Kastner, Swapnil Khadke, Carla B. Roces, Peter Stone
Pages 127-144
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- Melissa C. Hanson, Darrell J. Irvine
Pages 145-152
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- Manjari Lal, Jessica White, Changcheng Zhu
Pages 153-163
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- Sachin G. Thakkar, Zhengrong Cui
Pages 181-199
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- Cristina Maria de Barros, Emad Ibrahim Wafa, Khanidtha Chitphet, Kawther Ahmed, Sean M. Geary, Aliasger K. Salem
Pages 201-213
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- Michelle Y. Chan, Timothy S. Dutill, Ryan M. Kramer
Pages 215-226
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- Manvi Hasija, Anthony Sheung, Nausheen Rahman, Salvador F. Ausar
Pages 227-238
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- Michelle Y. Chan, Quinton M. Dowling, Sandra J. Sivananthan, Ryan M. Kramer
Pages 239-252
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- Quinton M. Dowling, Ryan M. Kramer
Pages 253-261
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- Kelly M. Rausch, Daming Zhu
Pages 263-271
Editors and Affiliations
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Infectious Disease Research Institute, Seattle, USA
Christopher B. Fox