Overview
- Includes cutting-edge methods and protocols
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
Part of the book series: Methods in Molecular Biology (MIMB, volume 1360)
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About this book
This volume focuses on screening and profiling kinase inhibitors or activators. Chapters in this book cover several facets of the drug discovery processes starting with target identification, and assay development and screening chemical libraries for hit identification and lead optimization. The profiling portion of Kinase Screening and Profiling: Methods and Protocols discusses several strategies and techniques that are required to minimize off target hits and reduce cellular toxicities that are caused by liability kinases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Timely and authoritative, Kinase Screening and Profiling: Methods and Protocols, will benefit scientists and researchers who are interested in exploring the role of kinases in academic, as well as pharmaceutical research.
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Keywords
Table of contents (15 protocols)
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: Kinase Screening and Profiling
Book Subtitle: Methods and Protocols
Editors: Hicham Zegzouti, Said A. Goueli
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-4939-3073-9
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2016
Hardcover ISBN: 978-1-4939-3072-2Published: 27 October 2015
Softcover ISBN: 978-1-4939-4923-6Published: 23 August 2016
eBook ISBN: 978-1-4939-3073-9Published: 26 October 2015
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: X, 223
Number of Illustrations: 19 b/w illustrations, 26 illustrations in colour
Topics: Protein Science