Overview
- Editors:
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Sara Cohen
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Israel Institute for Biological Research, Ness-Ziona, Israel
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Avigdor Shafferman
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Israel Institute for Biological Research, Ness-Ziona, Israel
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About this book
Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the development of new, advanced vaccines. In this volume, devoted to the proceedings of the 39th OHOLO Conference, we present some of the recent strategies for the design and production of novel vaccines. The advent of recombinant DNA technology has stimulated the production of several subunit vaccines. In spite of the obvious advantages to this approach, the limited immuno genicity of many subunit candidates has hindered their development. Strategies to enhance the immunogenicity of subunit vaccines is therefore critical. Several approaches toward this goal, including design of novel adjuvants and delivery systems as well as design of advantageous carriers, are presented here. Among the carriers evaluated here are polypep tides (flagellin, HBV core antigen, J3-galactosidase), attenuated virions (Vaccinia, Sindbis), and nonpathogenic licensed bacteria (Salmonella).
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Table of contents (23 chapters)
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Recombinant Antigens and Presentation Vectors
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- Bernard Moss, Miles W. Carroll, Linda S. Wyatt, Jack R. Bennink, Vanessa M. Hirsch, Simoy Goldstein et al.
Pages 7-13
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- F. Schödel, S. Kelly, S. Tinge, S. Hopkins, D. Peterson, D. Milich et al.
Pages 15-21
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- A. Shafferman, S. Lustig, Y. Inbar, M. Halevy, P. Schneider, T. Bino et al.
Pages 41-47
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- J. B. Ulmer, R. R. Deck, A. Yawman, A. Friedman, C. Dewitt, D. Martinez et al.
Pages 49-53
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Bacterial Vaccines - Novel Approaches
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- Rino Rappuoli, Mariagrazia Pizza, Gill Douce, Gordon Dougan
Pages 55-60
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- C. Pezard, J.-C. Sirard, M. Mock
Pages 69-72
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Strategies for HIV Vaccine
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- J. M. Gershoni, G. F. Denisova, D. Raviv, B. Stern, J. Zwickel
Pages 91-96
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Adjuvants and Delivery Systems
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- Rajesh K. Gupta, Paul Griffin Jr., An-Cheng Chang, Rachel Rivera, Roger Anderson, Bradford Rost et al.
Pages 105-113
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- D. Katz, S. Lehrer, O. Galan, B. Lachmi, S. Cohen, I. Inbar et al.
Pages 115-125
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Production Processes and Clinical Evaluation
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- O.-W. Merten, C. Hannoun, J.-C. Manuguerra, F. Ventre, S. Petres
Pages 141-151