Overview
- Provides a complete review of existing knowledge of molecular genetics in inflammatory bowel diseases
- Highlights the latest discoveries from molecular and genome-wide association studies
- Gives insight into disease pathogenesis and potential targets for pharmaceutical intervention
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About this book
Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisposing and protective roles (e.g. the multiple variants in the receptor for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these diseases and other chronic inflammatory diseases (e.g. psoriasis, multiple sclerosis, type 1 diabetes and many others).
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Table of contents (16 chapters)
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Front Matter
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The Foundation of IBD Genetics, Human and Animal Studies
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Front Matter
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The Genetic and Molecular Makeup of Inflammatory Bowel Disease
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Front Matter
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Pathogenetic Pathways in Inflammatory Bowel Disease
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Front Matter
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Concluding Remarks and Future Perspectives
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Front Matter
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Editors and Affiliations
Bibliographic Information
Book Title: Molecular Genetics of Inflammatory Bowel Disease
Editors: Mauro D'Amato, John D Rioux
DOI: https://doi.org/10.1007/978-1-4614-8256-7
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2013
Softcover ISBN: 978-1-4939-4256-5Published: 23 August 2016
eBook ISBN: 978-1-4614-8256-7Published: 05 October 2013
Edition Number: 1
Number of Pages: XIII, 343
Number of Illustrations: 23 illustrations in colour
Topics: Human Genetics, Molecular Medicine, Biomedicine general