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Mitochondrial Medicine

Volume 3: Manipulating Mitochondria and Disease- Specific Approaches

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  • © 2021
  • Latest edition

Overview

Editors:
  1. Volkmar Weissig

    1. Department of Pharmaceutical Sciences, Midwestern University, Glendale, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Marvin Edeas

    1. Cochin Hospital, Cochin Institute, INSERM U1016, PARIS, France

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    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2277)

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About this book

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume III guides readers through chapters on intercellular mitochondrial transfer, Cytoplasmic transfer methods, Ndufs4 knockout mouse, in vivo assessment of mitochondrial oxygen consumption, mitochondrial network analysis by imaging, mitochondrial respiration in platelets, Heterologous Inferential Analysis (HIA), bioenergetic profiling, integrative methods for studying cardiac energetics, and isolation and deep sequencing of mitochondrial DNA.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls.

 Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 3: Manipulating Mitochondria and Disease- Specific Approaches aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

 

 

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Table of contents (29 protocols)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Allotopic Expression of ATP6 in Mouse as a Transgenic Model of Mitochondrial Disease

    • David A. Dunn, Carl A. Pinkert
    Pages 1-13

  3. Mitochondrial Transplantation for Ischemia Reperfusion Injury

    • Ilias P. Doulamis, James D. McCully
    Pages 15-37

  4. Quantitatively Controlled Intercellular Mitochondrial Transfer by Cell Fusion-Based Method Using a Microfluidic Device

    • Ken-Ichi Wada, Kazuo Hosokawa, Yoshihiro Ito, Mizuo Maeda
    Pages 39-47

  5. Lipophilic Conjugates for Carrier-Free Delivery of RNA Importable into Human Mitochondria

    • Ilya Dovydenko, Mariya Meschaninova, Anne-Marie Heckel, Ivan Tarassov, Alya Venyaminova, Nina Entelis
    Pages 49-67

  6. Drug Discovery Assay to Identify Modulators of the Mitochondrial Ca2+ Uniporter

    • Daniela M. Arduino, Valerie Goh, Dejana Mokranjac, Fabiana Perocchi
    Pages 69-89

  7. Cytoplasmic Transfer Methods for Studying the Segregation of Mitochondrial DNA in Mice

    • Thomas Kolbe, Ralf Steinborn, Joerg P. Burgstaller
    Pages 91-99

  8. Electron Attachment to Isolated Molecules as a Probe to Understand Mitochondrial Reductive Processes

    • Stanislav A. Pshenichnyuk, Alberto Modelli
    Pages 101-124

  9. Assessment of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation

    • Matthias Hecker, Natascha Sommer, Konstantin Mayer
    Pages 125-132

  10. Assessment of the Effects of Drugs on Mitochondrial Respiration

    • Jana Hroudová, Zdeněk Fišar
    Pages 133-142

  11. The NDUFS4 Knockout Mouse: A Dual Threat Model of Childhood Mitochondrial Disease and Normative Aging

    • Anthony S. Grillo, Alessandro Bitto, Matt Kaeberlein
    Pages 143-155

  12. Suborganellar Localization of Mitochondrial Proteins and Transcripts in Human Cells

    • Anna Smirnova, Ludovic Richert, Alexandre Smirnov, Yves Mély, Ivan Tarassov
    Pages 157-173

  13. In Vivo Assessment of Mitochondrial Oxygen Consumption

    • Floor A. Harms, Egbert G. Mik
    Pages 175-185

  14. Update of Mitochondrial Network Analysis by Imaging: Proof of Technique in Schizophrenia

    • Yekaterina Yatchenko, Dorit Ben-Shachar
    Pages 187-201

  15. Heterologous Inferential Analysis (HIA) and Other Emerging Concepts: In Understanding Mitochondrial Variation In Pathogenesis: There is no More Low-Hanging Fruit

    • Antón Vila-Sanjurjo, Paul M. Smith, Joanna L. Elson
    Pages 203-245

  16. Accurate Measurement of Cellular and Cell-Free Circulating Mitochondrial DNA Content from Human Blood Samples Using Real-Time Quantitative PCR

    • Hannah Rosa, Afshan N. Malik
    Pages 247-268

  17. Measurement of Mitochondrial Respiration in Platelets

    • Zdeněk Fišar, Jana Hroudová
    Pages 269-276

  18. Isolation and Electron Microscopic Analysis of Liver Cancer Cell Mitochondria

    • Yaschar Kabiri, Carola Eberhagen, Sabine Schmitt, Percy A. Knolle, Hans Zischka
    Pages 277-287

  19. Assessment of Mitochondrial Reactive Oxygen Species and Redox Regulation in Stem Cells

    • Madhavee Thumiah-Mootoo, Tina Podinic, Mireille Khacho
    Pages 289-297

  20. Single-Cell Approaches for Studying the Role of Mitochondrial DNA in Neurodegenerative Disease

    • Laura J. Bailey, Joanna L. Elson, Ilse S. Pienaar
    Pages 299-329
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Editors and Affiliations

  • Department of Pharmaceutical Sciences, Midwestern University, Glendale, USA

    Volkmar Weissig

  • Cochin Hospital, Cochin Institute, INSERM U1016, PARIS, France

    Marvin Edeas

Bibliographic Information

  • Book Title: Mitochondrial Medicine

  • Book Subtitle: Volume 3: Manipulating Mitochondria and Disease- Specific Approaches

  • Editors: Volkmar Weissig, Marvin Edeas

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-1270-5

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-1269-9Published: 03 June 2021

  • Softcover ISBN: 978-1-0716-1272-9Published: 03 June 2021

  • eBook ISBN: 978-1-0716-1270-5Published: 02 June 2021

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XV, 468

  • Number of Illustrations: 32 b/w illustrations, 60 illustrations in colour

  • Topics: Biomedicine, general

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