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The complexarchitectureofneuronal networks togetherwith the extraordinary associated functions make the nervous system a fascinating biological structure. The considerable work performed to explore this cellular machinery is nowadays successfulbecause the mysteryofnervous system developmentisbeing unravelled. As described in their outstanding review published 10 years ago in Science.' Marc Tessier-Lavigne and Corey Goodman-the pioneers of the molecular era of axon guidance-summarized the assembly of nervous system connections as a subtle game of attraction and repulsion of neuronal growth cones. The cellular ballet ensuring the formation of billions of synapses, which ultimately gives rise to the highest cognitive functions, is primarily orchestrated by a step-by-step mechanism of growth driven by multiple molecular cues. While our general concept of axon guidance remains identical, a profound evolution ofour knowledge ofthe molecular identityofthe guidance cues together with their interactions and signalling pathways occurred over the past ten years. This book proposes an exhaustive and updated view ofthe current knowledge ofthe molecular and cellular mechanisms ensuring axon growth and guidance. An introductory chapterby C. Bouquetand F.Nothias will remind the readers ofall the features ofa growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one ofthe most fantastic developmental achievements: the nervous system wiring.
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Table of contents (12 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: Axon Growth and Guidance
Editors: Dominique Bagnard
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-0-387-76715-4
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2007
Hardcover ISBN: 978-0-387-76714-7Published: 11 January 2008
Softcover ISBN: 978-1-4419-2634-0Published: 19 November 2010
eBook ISBN: 978-0-387-76715-4Published: 10 December 2008
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XVI, 170
Number of Illustrations: 40 b/w illustrations, 7 illustrations in colour
Topics: Neurosciences, Biomedicine general, Pharmacology/Toxicology